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Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

16 Aug 2016

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants.

16 Aug 2016

Common gaming camera could be effective in evaluating walking difficulties of MS patients

A commonly used device found in living rooms around the world could be a cheap and effective means of evaluating the walking difficulties of multiple sclerosis (MS) patients.

16 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Study estimates health care costs of gastrointestinal illnesses in Switzerland

In Switzerland, between 300,000 and 700,000 patients per year visit a doctor due to acute diarrhoea. Until now, the financial burden on the Swiss health care system had been completely unclear.

12 Aug 2016

Researchers chart microbial ecology of the mouth at all stages of gum disease progression

Gingivitis, a common and mild form of gum disease can progress to periodontitis, a more serious infection that damages the soft tissue of the gums and sometimes even destroys the bone supporting the teeth.

12 Aug 2016

St. Jude scientists identify key innate immune sensor that attacks influenza virus

St. Jude Children's Research Hospital immunologists have identified the protein trigger in the body's quick-reaction innate immune system that specifically recognizes the influenza virus in infected cells and triggers their death.

12 Aug 2016

NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze.

12 Aug 2016

BCL-2 inhibitor shows promise in AML patients

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.

12 Aug 2016

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

11 Aug 2016

Researchers uncover one way breast cancer tumors resist vital medication

A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication.

11 Aug 2016

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers have used CRISPR -- a revolutionary new genetic engineering technique -- to convert cells isolated from mouse connective tissue directly into neuronal cells.

11 Aug 2016

Scientists activate neurons in the mouse brain by injecting virus containing light-sensitive proteins

Neurons that fire together really do wire together, says a new study in Science, suggesting that the three-pound computer in our heads may be more malleable than we think.

11 Aug 2016

Scientists provide new insights into workings of cancer-linked potassium channel

Most cells in the body carry on their surface tiny pores through which potassium ions travel. In controlling the flow of these positively charged ions, the channel helps the cell maintain its electrical balance.

11 Aug 2016

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Many cancers only become a mortal danger if they form metastases elsewhere in the body. Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body.

11 Aug 2016

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition.

11 Aug 2016

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

A first-time study published in PLOS ONE shows that a combined assessment of multiple types of protein biomarkers in the blood offers an important advancement for detecting early breast cancer.

11 Aug 2016

Mayo Clinic launches new blood test that measures plasma ceramides to predict risk for heart disease

Mayo Clinic has launched a new type of blood test that will be used to predict adverse cardiovascular events in patients with progressing coronary artery disease (CAD).

11 Aug 2016

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

A novel PET radiotracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital is able for the first time to reveal epigenetic activity - the process that determines whether or not genes are expressed - within the human brain.

11 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

Laboratory News and Research

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

German scientists develop new approach to prevent GvHD after bone marrow transplants

Common gaming camera could be effective in evaluating walking difficulties of MS patients

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Study estimates health care costs of gastrointestinal illnesses in Switzerland

Researchers chart microbial ecology of the mouth at all stages of gum disease progression

St. Jude scientists identify key innate immune sensor that attacks influenza virus

NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

BCL-2 inhibitor shows promise in AML patients

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

Researchers uncover one way breast cancer tumors resist vital medication

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Scientists activate neurons in the mouse brain by injecting virus containing light-sensitive proteins

Scientists provide new insights into workings of cancer-linked potassium channel

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

Mayo Clinic launches new blood test that measures plasma ceramides to predict risk for heart disease

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

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