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Clinical data added to ORENCIA labeling help treat patients with rheumatoid arthritis

Bristol-Myers Squibb Company announced today that clinical data added to the labeling for ORENCIA (abatacept) support use of ORENCIA for patients with moderate to severe rheumatoid arthritis of less than or equal to two years duration.

27 Aug 2009

Studies suggest that venous ischemia causes greater injury than arterial ischemia

The research team led by Professor Guzman-de la Garza of the Autonomous University of Nuevo Leon, Mexico, used a rodent model of intestinal I/R to study the different inflammatory mediators that are associated with venous, arterial or total vascular occlusion.

27 Aug 2009

New study identifies smoking as a risk factor for active TB

Smoking is a risk factor for active tuberculosis (TB) disease, according to a new study on TB incidence in Taiwan.

24 Aug 2009

Genentech announces Phase III study results for Avastin (bevacizumab) in combination with chemo in HER2-negative breast cancer

Genentech, Inc. today announced that a Phase III study (RIBBON 2) of Avastin (bevacizumab) in combination with chemotherapy increased the time women with metastatic HER2-negative breast cancer whose initial chemotherapy had stopped working lived without the disease worsening (progression-free survival or PFS), compared to chemotherapy alone.

18 Aug 2009

FDA approves Extavia for multiple sclerosis

The US Food and Drug Administration (FDA) has approved Extavia(R) (interferon beta-1b), the first in a new planned portfolio of multiple sclerosis (MS) medicines from Novartis to help patients manage this devastating disease.

17 Aug 2009

Expert available on recent FDA analysis of TNF blockers

Lloyd J. Old, M.D., is Director of the Ludwig Institute for Cancer Research (LICR) New York Branch. He is also Director of the Cancer Research Institute (CRI) Scientific Advisory Council, Director of the CRI/LICR Cancer Vaccine Collaborative, and Director of the CRI Cancer Vaccine Consortium. He has been a Member of the National Academy of Sciences since 1978.

9 Aug 2009

Golimumab shows promise for rheumatoid arthritis

Golimumab, a new tumour necrosis factor-α (TNF-α) inhibitor reduces the signs and symptoms of rheumatoid arthritis in patients who have previously received any other TNF-α inhibitor, and might be a good option for patients who have inadequate responses to one or two other TNF-α inhibitors, finds an Article published Online first and in this week's edition of The Lancet.

28 Jun 2009

Roche files MabThera as a first-line biologic treatment for rheumatoid arthritis in Europe

Roche has announced that it has submitted a combined filing to the European health authorities (the European Medicines Agency) for three new indications to extend the label for MabThera to use as a first-line biologic therapy for patients with rheumatoid arthritis (RA).

28 Jun 2009

Ancient skeletal evidence for leprosy in India

A biological anthropologist from Appalachian State University working with an undergraduate student from Appalachian, an evolutionary biologist from UNC Greensboro, and a team of archaeologists from Deccan College (Pune, India) recently reported analysis of a 4000-year-old skeleton from India bearing evidence of leprosy. This skeleton represents both the earliest archaeological evidence for human infection with Mycobacterium leprae in the world and the first evidence for the disease in prehistoric India.

26 May 2009

Cimzia approved in U.S. for rheumatoid arthritis

UCB announced today that the U.S. Food and Drug Administration (FDA) approved Cimzia, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA).

13 May 2009

Drugs designed to tackle endoplasmic reticulum stress might be useful in treating heart disease

Researchers say they have evidence to explain what separates your average blood vessel plaque from those that are at high risk for triggering the development of dangerous - even fatal - blood clots.

5 May 2009

Senior men more likely than women to die after pneumonia

Differing biological response to infection between men and women may explain higher death rates among older men who are hospitalized with community-acquired pneumonia (CAP).

29 Apr 2009

New applications for proton pump inhibitors

In a new study, published in the May issue of Elsevier's Experimental Neurology (www.elsevier.com/locate/yexnr), scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug.

22 Apr 2009

Engineered antibody gives cancer the recognition it deserves

In concept, the human immune system has the power to destroy cancer cells with great specificity.

22 Apr 2009

New insights into protein p75's role Alzheimer's disease

New research at the Salk Institute for Biological Studies casts the role of a neuronal growth factor receptor - long suspected to facilitate the toxic effects of beta amyloid in Alzheimer's disease - in a new light, suggesting the molecule actually protects the neuron in the periphery from beta amyloid-induced damage.

21 Apr 2009

Overexpression of PEA-15 protein shrinks breast cancer tumors

Overexpression of PEA-15, which binds and drags an oncoprotein out of the cell nucleus where it fuels cancer growth, steeply reduced breast cancer tumors in a preclinical experiment, researchers at The University of Texas M. D. Anderson Cancer Center reported at the 100th annual meeting of the American Association for Cancer Research.

20 Apr 2009

Necrosis News and Research

Clinical data added to ORENCIA labeling help treat patients with rheumatoid arthritis

Studies suggest that venous ischemia causes greater injury than arterial ischemia

New study identifies smoking as a risk factor for active TB

Genentech announces Phase III study results for Avastin (bevacizumab) in combination with chemo in HER2-negative breast cancer

FDA approves Extavia for multiple sclerosis

Expert available on recent FDA analysis of TNF blockers

Golimumab shows promise for rheumatoid arthritis

Roche files MabThera as a first-line biologic treatment for rheumatoid arthritis in Europe

Ancient skeletal evidence for leprosy in India

Cimzia approved in U.S. for rheumatoid arthritis

Drugs designed to tackle endoplasmic reticulum stress might be useful in treating heart disease

Senior men more likely than women to die after pneumonia

New applications for proton pump inhibitors

Engineered antibody gives cancer the recognition it deserves

New insights into protein p75's role Alzheimer's disease

Overexpression of PEA-15 protein shrinks breast cancer tumors

Study looks at effect of transcatheter arterial chemoembolization on liver function

Vitamin D deficiency is associated with inflammation in healthy women

Trial of new biologic agent to treat psoriatic arthritis

Research looks at the elimination of hepatitis B and C

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