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Researchers reveal how certain lipids help adenoviruses to enter the cell

Adenoviruses cause numerous diseases, such as eye or respiratory infections, and they are widely used in gene therapy. Researchers from the University of Zurich have now discovered how these viruses penetrate the cells, a key step for infection and gene delivery. The cell unwillingly supports virus entry and infection by providing lipids that are normally used to repair damaged membranes.

10 Jul 2015

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of Health.

10 Jul 2015

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

Tillotts Pharma AG, part of the Zeria Group, announced today that it has entered into an agreement for the acquisition of the global rights for Entocort (budesonide) from AstraZeneca, excluding the U.S., which will remain with AstraZeneca.

9 Jul 2015

EvoRx Technologies, AstraZeneca successfully complete research collaboration

AstraZeneca and EvoRx Technologies successfully completed a one-year research collaboration leveraging EvoRx's proprietary Evo-Link technology to discover cell penetrating peptides for a high value intracellular protein–protein interaction target in the respiratory portfolio.

9 Jul 2015

New nanometer catalyst filter removes 100% of particle substances of cigarette smoke

The research team led by Dr. Jongsoo Jurng and Dr. Gwi-Nam at KIST stated that, "In cooperation with KT&G, KIST has developed a nano-catalyst filter coated with a manganese oxide-based nano-catalyst, which can be used in a smoking room to reduce and purify major harmful substances of cigarette smoke.

9 Jul 2015

Adolescents more likely to try e-cigarettes when exposed to TV ads

Adolescents who are exposed to e-cigarette TV advertising are more likely to try e-cigarettes in the future, according to a groundbreaking experiment from researchers at RTI International. Although advertising and adolescent use of e-cigarettes have simultaneously increased in recent years, this is the first study to demonstrate a direct link between adolescents' exposure to advertising and their likelihood of future use.

8 Jul 2015

Sepsis readmissions have significant impact on health care expenditures in California

The Affordable Care Act created several national initiatives aimed at reducing hospital readmission rates for heart attacks, congestive heart failure and other common high-risk conditions. But there is still no national program intended to address sepsis, a potentially life-threatening illness caused by infection.

8 Jul 2015

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Investigators have discovered the precise molecular steps that enable immune cells implicated in certain forms of asthma and allergy to develop and survive in the body. The findings from Weill Cornell Medical College reveal a new pathway that scientists could use to develop more effective treatments and therapies for the chronic lung disorder.

7 Jul 2015

New portable system can produce life-saving NO from air by means of electrical spark

Treatment with inhaled nitric oxide (NO) has proven to be life saving in newborns, children and adults with several dangerous conditions, but the availability of the treatment has been limited by the size, weight and complexity of equipment needed to administer the gas and the therapy's high price.

7 Jul 2015

Unique diagnostic test could help detect world's deadliest superbugs, infectious diseases

Infectious diseases such as hepatitis C and some of the world's deadliest superbugs--C. difficile and MRSA among them--could soon be detected much earlier by a unique diagnostic test, designed to easily and quickly identify dangerous pathogens.

7 Jul 2015

Researchers awarded grant from British Council to reduce burden of infectious disease in Malaysia

A group of collaborators led by the University of Southampton have been awarded a British Council Newton Fund Institutional Links Grant to support ground-breaking research towards reducing the burden of infectious disease in Malaysia.

7 Jul 2015

Celtaxsys receives FDA clearance to begin acebilustat Phase 2 trial in adult CF patients in the US

Celtaxsys, Inc., a clinical stage pharmaceutical development company focusing on anti-inflammatory therapeutics, including those with rare and orphan inflammatory disease indications, announced today that it has gained clearance from the U.S. Food and Drug Administration to begin a Phase 2 clinical trial of its flagship drug candidate, acebilustat (CTX-4430), in adult CF patients in the US.

7 Jul 2015

New treatment option available for CLL patients in Manitoba and Saskatchewan

People in Manitoba and Saskatchewan living with Chronic Lymphocytic Leukemia (CLL) will now be able to access a new treatment option through the prescription drug insurance plans in both provinces. Earlier this week, GAZYVA (obinutuzumab) in combination with chlorambucil chemotherapy was added to benefits formularies of the Provincial Oncology Drug Programs at CancerCare Manitoba and the Saskatchewan Cancer Agency.

6 Jul 2015

Harvard Medical School scientists reveal structure of vesicular stomatitis virus protein

Viruses need us. In order to multiply, viruses have to invade a host cell and copy their genetic information. To do so, viruses encode their own replication machinery or components that subvert the host replication machinery to their advantage.

3 Jul 2015

Gene therapy improves lung function in patients with cystic fibrosis

Gene therapy was shown to provide significant benefits for patients with cystic fibrosis in a recent clinical study published in The Lancet Respiratory Medicine journal.

3 Jul 2015

Gene therapy for cystic fibrosis shows significant benefit in lung function

For the first time gene therapy for cystic fibrosis has shown a significant benefit in lung function compared with placebo, in a phase 2 randomised trial published in The Lancet Respiratory Medicine journal. The technique replaces the defective gene response for cystic fibrosis by using inhaled molecules of DNA to deliver a normal working copy of the gene to lung cells.

3 Jul 2015

Researchers explore how Sox9 protein regulates production of cartilage

Cartilage does a lot more than determine the shapes of people's ears and noses. It also enables people to breathe and to form healthy bones -- two processes essential to life. In a study published in Cell Reports, USC Stem Cell researcher Xinjun He and University of Tokyo researcher Shinsuke Ohba explore how a protein called Sox9 regulates the production of cartilage.

3 Jul 2015

Mortality rates vary depending on socioeconomic differences among areas in Europe

For a number of years now, scientific literature has questioned whether mortality rates depend on socioeconomic differences among the population. Recently, a new study carried out in 15 European cities - including Barcelona and Madrid - detected inequalities for the majority of causes, concluding that higher levels of poverty are associated with higher mortality rates and there is a great deal of variation among areas.

2 Jul 2015

Educational messages about naloxone's lifesaving benefits can bolster support for its use

While most Americans do not support policies designed to increase distribution of naloxone - a medication that reverses the effects of a drug overdose - certain types of educational messages about its lifesaving benefits may bolster support for its use, new Johns Hopkins Bloomberg School of Public Health research suggests.

2 Jul 2015

Domainex’s new integrated bioassay service platform accelerates progression of drug discovery projects

Domainex Ltd, a private drug discovery service company, today announces that it is launching an integrated bioassay service platform, BioassayBuilder.

2 Jul 2015

Respiratory News and Research

Researchers reveal how certain lipids help adenoviruses to enter the cell

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

EvoRx Technologies, AstraZeneca successfully complete research collaboration

New nanometer catalyst filter removes 100% of particle substances of cigarette smoke

Adolescents more likely to try e-cigarettes when exposed to TV ads

Sepsis readmissions have significant impact on health care expenditures in California

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

New portable system can produce life-saving NO from air by means of electrical spark

Unique diagnostic test could help detect world's deadliest superbugs, infectious diseases

Researchers awarded grant from British Council to reduce burden of infectious disease in Malaysia

Celtaxsys receives FDA clearance to begin acebilustat Phase 2 trial in adult CF patients in the US

New treatment option available for CLL patients in Manitoba and Saskatchewan

Harvard Medical School scientists reveal structure of vesicular stomatitis virus protein

Gene therapy improves lung function in patients with cystic fibrosis

Gene therapy for cystic fibrosis shows significant benefit in lung function

Researchers explore how Sox9 protein regulates production of cartilage

Mortality rates vary depending on socioeconomic differences among areas in Europe

Educational messages about naloxone's lifesaving benefits can bolster support for its use

Domainex’s new integrated bioassay service platform accelerates progression of drug discovery projects

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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