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Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Genetic target found for pediatric leukemia

A molecular target newly discovered by scientists at two prestigious research institutes may pave the way for new treatments that could combat an aggressive form of leukemia, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Temperature sensing protein implicated in mediating thermotaxis

The songwriter Noel Coward once declared that only mad dogs and Englishmen went out in the midday sun. MIT biologists Mark Rosenzweig, Paul Garrity and their colleagues now have a third candidate for the lyric—fruit flies with defects in a gene called dTrpA1.

4 Dec 2004

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

Cancer Research Technology Limited has announced that AstraZeneca has licensed exclusive worldwide rights to a patent family relating to a nuclear receptor/co-activator binding motif.

1 Dec 2004

Novel anti-obesity compound shows promise for treatment of obesity

Arena Pharmaceuticals announced today results from the dosing phase of its Phase 1b clinical trial of APD356, an orally administered small molecule designed to regulate satiety (and perhaps metabolism) for the treatment of obesity.

30 Nov 2004

Rimonabant could be safer for treating obesity than previous weight-loss drugs

ECRI, a nonprofit health services research agency, recently published a Health Technology Forecast profile on a novel pharmaceutical agent that is in development for the treatment of obesity.

30 Nov 2004

New trial to test cancer smart drugs

Cancer Research UK has launched a major new clinical trial for the most common form of lung cancer, to test the effectiveness of one of the new generation of 'smart' cancer drugs as a first line treatment.

29 Nov 2004

T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease

The authors explain this detour by showing that an attractant protein that normally directs T cells into the gut is aberrantly produced in the liver during PSC. T cells expressing the receptor for the protein are thus re-routed to the liver

29 Nov 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

MedImmune and Medarex have announced a collaboration to develop antibodies

MedImmune and Medarex have announced a collaboration to develop antibodies targeting interferon-alpha and the type I interferon receptor 1.

24 Nov 2004

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth.

24 Nov 2004

Experimental compound prevents cholesterol gallstone disease

A promising experimental compound prevents cholesterol gallstone disease in mice by stimulating the biochemical pathway that controls bile acid secretion by the liver, according to new studies by Howard Hughes Medical Institute researchers.

23 Nov 2004

New mechanism that contributes to the development of some breast and ovarian cancers

Researchers at Mount Sinai School of Medicine have discovered a new mechanism of activation of a pathway known to be implicated in many cancers.

23 Nov 2004

FDA approves Tarceva (erlotinib)

OSI Pharmaceuticals and Genentech have announced that the U.S. Food and Drug Administration (FDA) has approved, after priority review, Tarceva (erlotinib) for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen.

20 Nov 2004

Unusual protein pair that stops blood vessels' growth in the developing back

In experiments with mice, a research team led by Johns Hopkins scientists has discovered an unusual protein pair that stops blood vessels' growth in the developing back.

18 Nov 2004

Research provides more evidence of communication between developing nerves and blood vessels

In a developing embryo, the growth of nerves cannot outpace the establishment of life-giving blood vessels. Now, researchers have found that a protein intimately involved in blood vessel patterning actually belongs to a family of proteins known to guide neural development.

18 Nov 2004

Receptor News and Research

Researchers step closer to cure for common childhood cancer

Genetic target found for pediatric leukemia

Temperature sensing protein implicated in mediating thermotaxis

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

Novel anti-obesity compound shows promise for treatment of obesity

Rimonabant could be safer for treating obesity than previous weight-loss drugs

New trial to test cancer smart drugs

T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease

New research may lead to treatments for atherosclerosis

MedImmune and Medarex have announced a collaboration to develop antibodies

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Experimental compound prevents cholesterol gallstone disease

New mechanism that contributes to the development of some breast and ovarian cancers

FDA approves Tarceva (erlotinib)

Unusual protein pair that stops blood vessels' growth in the developing back

Research provides more evidence of communication between developing nerves and blood vessels

New findings have implications for chronic use of COX-2 Inhibitors in pre-menopausal women

Generic antipsychotic drugs can protect brain cells from progressive multifocal leukoencephalopathy

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

What makes beer taste so darn good to men, but vile to most women?

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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