Antimicrobial Drug News and Research

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Antimicrobials are substance that kills microorganisms such as bacteria or mold, or stops them from growing and causing disease.

Silver-coated endotracheal tube reduces infections from highly resistant bacteria

A silver-coated endotracheal tube may reduce infections with highly resistant bacteria over traditional tubes by nearly half, according to the results of a large randomized trial to be presented at the American Thoracic Society's 2008 International Conference in Toronto on Monday, May 19.

19 May 2008

PolyMedix receives clearance to initiate phase I clinical study of novel systemic antibiotic compound

PolyMedix, Inc. has received a notice of no objection from Health Canada for the Company's Clinical Trial Application ("CTA") for its defensin mimetic antibiotic compound, PMX-30063. This notice of no objection allows for the initiation of human clinical studies in Canada. PMX-30063 is the first defensin mimetic antibiotic compound cleared to enter human clinical trials for systemic use, representing an entirely new class of antibiotic drugs.

9 May 2008

The design of a vaccine against Leishmaniasis

The parasitology team at the "Severo Ochoa" Molecular biology centre (CSIC-UAM) has focused its research efforts on the search for a vaccine capable of activating immunity against the parasite that causes leishmaniasis.

7 May 2008

Doctors should consider alternatives to antibiotics for sinusitis

When suffering through a sinus infection, many people ask for an antibiotic to speed their recovery. However, a recent review of clinical trials found that while antibiotics can provide minor improvements in uncomplicated sinusitis cases, most patients recover without the drugs within two weeks.

24 Apr 2008

Silver nanoparticles to improve the safety of the world's food supply

Byron Brehm-Stecher, assistant professor in food science and human nutrition, has some big ideas for his work with tiny particles.

11 Apr 2008

Mud may help fight MRSA infections

Scientists in Arizona report that minerals from clay could form the basis of a new generation of inexpensive, highly-effective antimicrobials for fighting MRSA infections that are moving out of health care settings and into the community.

7 Apr 2008

Alligator blood may provide a source of powerful new antibiotics

Despite their reputation for deadly attacks on humans and pets, alligators are wiggling their way toward a new role as potential lifesavers in medicine, biochemists in Louisiana reported today at the 235th national meeting of the American Chemical Society.

7 Apr 2008

Alligator blood extract promises to help fight superbugs

Biochemists from Louisiana in the U.S. say blood from alligators could help fight deadly 'superbugs' and other infections.

7 Apr 2008

Lyme disease - a tough nut to crack!

The bacteria that cause Lyme disease, the most common tick-borne illness in the United States, can linger in mouse tissues long after a full round of antibiotic treatment is completed, report researchers from the University of California, Davis.

2 Apr 2008

Caspase-12: MUHC researcher finds new defense mechanism against intestinal inflammation

The body's first line of defence against pathogenic bacteria that we ingest may not be the immune system but rather the cells that line the intestine.

13 Mar 2008

New findings do not support recommendation for universal screening on hospital admission for MRSA

New findings do not support the recommendation for universal screening on hospital admission for methicillin-resistant Staphylococcus aureus (MRSA) to reduce the rate of hospital-acquired infections in surgical patients, according to a study in the March 12 issue of JAMA.

12 Mar 2008

Tackling antimicrobial resistance

Drug resistance is making many diseases increasingly difficult and sometimes impossible to treat, according to Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

11 Mar 2008

Nasal vaccine for smallpox protects animals against 77 times the potentially lethal dose of smallpox

Scientists at NanoBio Corporation and the University of Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the potentially lethal dose of smallpox, and without the safety risks of current vaccines for smallpox.

27 Feb 2008

Scientists identify proteins that help bacteria put up a fight

Scientists have identified the role of two proteins that contribute to disease-causing bacteria cells' versatility in resisting certain classes of antibiotics.

27 Feb 2008

Questions over use of antibiotics in 'end of life' care

Antibiotics appear to be frequently prescribed to individuals with advanced dementia in nursing homes, especially in the two weeks before death, according to a report in the February 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

26 Feb 2008

Newly discovered ERK pathway proteins related to CagA induced disease

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer.

25 Feb 2008

Researchers examine animal antibiotic resistance, possible human link

It's bad enough when pathogenic bacteria work their way into the animal food supply.

20 Feb 2008

Mathematical approach to tackle dual-resistant hospital infections

A mathematical model that looks at different strategies for curbing hospital-acquired infections suggests that antimicrobial cycling and patient isolation may be effective approaches when patients are harboring dual-resistant bacteria.

17 Feb 2008

Researchers find new U.S. trend in antibiotic resistance

A research team from The University of Texas Health Science Center at San Antonio, examining bacterial isolates obtained in hospital and non-hospital clinical settings between 2000 and 2006, has identified drug-resistant strains of E. coli and Klebsiella bacteria in more than 50 blood, urine and respiratory samples.

11 Feb 2008

Unique fungal collection could hold key to future antibiotics

Scientists at Royal Holloway, University of London have joined forces with CABI to establish a facility to screen for potential new antibiotics.

23 Jan 2008

Antimicrobial Drug News and Research

Silver-coated endotracheal tube reduces infections from highly resistant bacteria

PolyMedix receives clearance to initiate phase I clinical study of novel systemic antibiotic compound

The design of a vaccine against Leishmaniasis

Doctors should consider alternatives to antibiotics for sinusitis

Silver nanoparticles to improve the safety of the world's food supply

Mud may help fight MRSA infections

Alligator blood may provide a source of powerful new antibiotics

Alligator blood extract promises to help fight superbugs

Lyme disease - a tough nut to crack!

Caspase-12: MUHC researcher finds new defense mechanism against intestinal inflammation

New findings do not support recommendation for universal screening on hospital admission for MRSA

Tackling antimicrobial resistance

Nasal vaccine for smallpox protects animals against 77 times the potentially lethal dose of smallpox

Scientists identify proteins that help bacteria put up a fight

Questions over use of antibiotics in 'end of life' care

Newly discovered ERK pathway proteins related to CagA induced disease

Researchers examine animal antibiotic resistance, possible human link

Mathematical approach to tackle dual-resistant hospital infections

Researchers find new U.S. trend in antibiotic resistance

Unique fungal collection could hold key to future antibiotics

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