Oncogenesis News and Research

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Researchers show why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in different cancers

Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what happens after the initial mutation that leads to dangerous later-stage cancers with multiple damaged genes.

13 Apr 2005

Oncolytic viruses may one day help treat brain tumors

New research shows that a virus designed to kill cancer cells can significantly increase the survival of mice with an incurable human brain tumor, even in some animals with advanced disease.

7 Apr 2005

Molecule called DJ-1 is likely to be involved in the generation of human tumors

Scientists have discovered that a molecule called DJ-1 is likely to be involved in the generation of human tumors through negative regulation of the well-known tumor suppressor, PTEN. The research, published in the March issue of Cancer Cell, has important implications for determining the prognosis of some human cancers, and may prove to be a suitable target for cancer therapy.

14 Mar 2005

Mitochondria - the energy factories in our cells - can sustain a cancer

University of Glasgow scientists have discovered how mitochondria - the energy factories in our cells - can sustain a cancer, reporting their findings in a new study published in Cancer Cell.

31 Jan 2005