DNA Damage News and Research

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The p53 transcription factor plays a vital role in preventing cancer onset

Researchers at the Uppsala Branch of the Ludwig Institute for Cancer Research have discovered that the transcription factor Yin Yang 1 (YY1) is a novel regulator of the tumor suppressor p53, which is inactivated in at least half of all human cancers.

2 Aug 2004

Further evidence about how estrogen helps activate breast cancer

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women.

29 Jul 2004

The structure of AGT shows how one human protein reduces the potency of chemotherapy

The fine details of this x-ray structure may help scientists find ways to fight certain cancers, such as brain tumors, which express high levels of AGT making them resistant to chemotherapy.

9 Jul 2004

Sunscreen to protect the skin's genetic material, or DNA

A new company, DNAcare Systems, is to be formed at the University of Newcastle upon Tyne, based on research by skin cancer expert Dr Mark Birch-Machin and colleagues.

8 Jul 2004

How DNA repair machinery detects and corrects errors in DNA replication

Biochemists at Duke University Medical Center have discovered key components that enable the cell's DNA repair machinery to adeptly launch its action in either direction along a DNA strand to strip out faulty DNA.

2 Jul 2004

New York study reveals that babies in the womb are more sensitive than their mothers to DNA damage from pollution

A new study of the effects of combustion-related air pollutants in New York City reveals that babies in the womb are more sensitive than their mothers to DNA damage from such pollution.

26 Jun 2004

Newborns are more susceptible to DNA damage from pollution than their mothers

New Study of New York City Residents Shows That Newborns are More Susceptible to DNA Damage from Pollution than Their Mothers.

24 Jun 2004

Don't tell your Grandma! Brussel sprouts could help protect against cancer

“DNA damage is associated with cancer risk. Sources of DNA damage include diet-related carcinogens, and bodily processes like oxidative stress – and the raw sprouts protect against this kind of damage.

23 Jun 2004

Targeting a gene that protects cancer cells from the lethal effects of radiotherapy could help improve the impact of treatment

Targeting a gene that protects cancer cells from the lethal effects of radiotherapy could help improve the impact of treatment, a leading Cancer Research UK scientist will tell conference delegates in Glasgow this week.

21 Jun 2004

Study may help oncologists tailor chemotherapy to patients based on their genetic make-up

Genetic variations in an individual’s ability to repair DNA damage may help predict survival in lung cancer patients treated with the common chemotherapy drugs cisplatin or carboplatin, a new study shows.

2 Jun 2004

Cell division can be halted in multiple ways, with implications for cancer

Brown University researchers have found that there are multiple independent ways to stop cell division, a phenomenon that prevents the spread of genetic mutation, which can make cells cancerous. Results of this research, along with an accompanying editorial, were published in the current issue of the journal Molecular Cell.

20 May 2004

Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer

Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer, Cancer Research UK scientists confirm in a major new international study published in the June edition of the American Journal of Human Genetics.

17 May 2004

Biochip technology to revolutionise the pharmaceutical industry

Advancements in biotechnology have culminated in its integration with semiconductor technologies such as micro-electromechanical systems, resulting in the evolution of biochips. Biochips provide pharma companies with sophisticated tools for speedy development of drugs and accurate diagnosis and understanding of biological mechanisms.

13 May 2004

UK scientists have discovered cancer cells life and death scenario following anti-cancer treatment

CANCER Research UK scientists have discovered how some cancer cells choose to live and others die following anti-cancer treatment, unveiling their findings in the prestigious journal PNAS today.

26 Apr 2004

Certain prostate cancer cell lines are unable to repair DNA damage caused by "free radicals"

16 Apr 2004

DNA free radical damage research

Certain prostate cancer cell lines are unable to repair DNA damage caused by "free radicals," according to scientists at the National Institute of Standards and Technology (NIST) and National Institutes of Health (NIH). This type of damage has been implicated before in the development of prostate cancer, but the new research provides the first solid evidence that the normal repair process is altered in prostate cancer cells, possibly leading to a cascade of events that culminate in further DNA damage and cellular dysfunction.

9 Apr 2004

Completion of the sequencing of human chromosome 19

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. This achievement is described in the April 1, 2004 edition of the journal Nature.

7 Apr 2004

Gene-rich human Chromosome 19 sequence completed

31 Mar 2004

p53 protein peptide stops cancer in its tracks

Researchers have dreamed of thwarting cancer by using proteins that halt cell growth and kill the tumor. In theory, the approach should work. In practice, however, scientists have not had an easy time of getting tumor suppressor proteins into cells where they can block growth effectively.

26 Mar 2004