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Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

UNSW researchers have used CRISPR gene editing – a type of 'molecular scissors' – to understand how deletions in one area of the genome can affect the expression of nearby genes.

8 Apr 2022

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Expanding prescription of statin medication to reduce low-density lipoprotein cholesterol could be a cost-effective intervention against cardiovascular disease, according to a Northwestern Medicine study published in the journal Circulation.

8 Apr 2022

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

New findings from the ongoing Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidence of Alzheimer's disease and related dementias in people with cardiovascular disease.

8 Apr 2022

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

Most autoimmune diseases are easy to diagnose but hard to treat. A paper published today in Science proposes using your unique immune cell fingerprint to rapidly identify which treatments will work for your autoimmune disease.

7 Apr 2022

NHLBI researchers support multiple programs to address pregnancy-related health disparities

During Black Maternal Health Week, April 11-17, and in preparation for Women's Health Month in May, researchers are raising awareness about pregnancy-related complications that disproportionately affect Black people.

7 Apr 2022

Insufficient sleep could play a role in the development of type 2 diabetes

People who have difficulty getting to sleep or staying asleep had higher blood sugar levels than people who rarely had sleep issues, new research has found.

6 Apr 2022

Study examines link between reproductive factors and dementia risk

Pregnancy, long reproductive span, and older age at menopause are associated with a lower risk of dementia in women, according to a study publishing April 5th in the open access journal PLOS Medicine.

6 Apr 2022

Cryo-EM imaging of a key immune protein reveals previously unrecognized binding site

Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report in a new study.

6 Apr 2022

Emergency C-section may compromise development and long-term health of babies

Labor and natural childbirth causes stress on a mother’s body but an emergency Caesarean is associated with even more inflammatory gene expression in the placenta, new South Australian research shows.

6 Apr 2022

Discovery could lead to new treatments for schistosomiasis

A team led by UTSW researchers has identified a molecule produced by male parasitic worms called schistosomes that prompts sexual maturity in females of these species.

5 Apr 2022

Difficult experiences in childhood influence vaccine resistance in adulthood

Curious about why some people have been so passionately, often angrily, opposed to vaccination against the COVID-19 virus, a team of researchers with access to rare and unusual insights into the childhood forces that shape our adult lives thought they'd try to find out.

5 Apr 2022

Study provides new insights into cause of metastasis in prostate cancer

Prostate cancers remain localized in the majority of cases, giving affected individuals a good chance of survival.

4 Apr 2022

Global study demonstrates some benefits of flu vaccine in people with heart failure

People with heart failure who received an annual flu shot had lower rates of pneumonia and hospitalization on a year-round basis and a reduction in major cardiovascular events during peak flu season, in a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Hypertension treatment during pregnancy benefits pregnant women and their babies

Adults treated with medication for high blood pressure present before or during the first 20 weeks of pregnancy, defined as chronic hypertension in pregnancy, had fewer adverse pregnancy outcomes compared to adults who did not receive antihypertensive treatment, according to a study supported by the National Institutes of Health.

2 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Medical Research News and Research

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

NHLBI researchers support multiple programs to address pregnancy-related health disparities

Insufficient sleep could play a role in the development of type 2 diabetes

Study examines link between reproductive factors and dementia risk

Cryo-EM imaging of a key immune protein reveals previously unrecognized binding site

Emergency C-section may compromise development and long-term health of babies

Discovery could lead to new treatments for schistosomiasis

Difficult experiences in childhood influence vaccine resistance in adulthood

Study provides new insights into cause of metastasis in prostate cancer

Global study demonstrates some benefits of flu vaccine in people with heart failure

Hypertension treatment during pregnancy benefits pregnant women and their babies

Research illuminates why immune disorders affect only one of two identical twins

Adolescents with higher drug use severity do not transition out of symptomatic substance use

Potential new approach could make Japanese encephalitis vaccine more affordable

UW Medicine scientists contribute to the publication of first complete, gapless genome sequence

NIH-sponsored trial of second COVID-19 booster shots begins enrolling adult participants

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