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Brainbow technique reveals surprising data about brain's visual circuitry

Neuroscientists know that some connections in the brain are pruned through neural development. Function gives rise to structure, according to the textbooks. But scientists at the Virginia Tech Carilion Research Institute have discovered that the textbooks might be wrong.

28 Aug 2015

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.

27 Aug 2015

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

Health providers trained to perform malaria rapid diagnostic tests (RDT) are still prescribing valuable malaria medicines to patients who do not have malaria, according to new research published in PLOS ONE.

27 Aug 2015

Study sheds further light on the way APOL1 protein kills trypanosmoe

The African trypanosome Trypanosoma brucei is a blood parasite capable of infecting many mammals. Humans are provided with natural immunity against infection through the activity of the protein apolipoprotein L1 (APOL1): captured via endocytosis, APOL1 forms pores in the lysosomal membrane, leading to the death of the trypanosome.

27 Aug 2015

New ORNL interface can identify, characterize solid or liquid sample

In mere seconds, a system developed at the Department of Energy's Oak Ridge National Laboratory can identify and characterize a solid or liquid sample, providing a valuable tool with applications in material science, forensics, pharmaceuticals, biology and chemistry.

27 Aug 2015

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

Liver transplantation is currently the only established treatment for patients with end stage liver failure. However, this treatment is limited by the shortage of donors and the conditional integrity and suitability of the available organs. Transplanting donor hepatocytes (liver cells) into the liver as an alternative to liver transplantation also has drawbacks as the rate of survival of primary hepatocytes is limited and often severe complications can result from the transplantation procedure.

27 Aug 2015

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

About 3% of colorectal cancers are due to Lynch syndrome, an inherited cancer susceptibility syndrome that predisposes individuals to various cancers. Close blood relatives of patients with Lynch syndrome have a 50% chance of inheritance. The role that PMS2 genetic mutations play in Lynch syndrome has been underestimated in part due to technological limitations.

27 Aug 2015

Researchers design online database to help researchers identify cancer gene mutations

Many clinical trials use genome sequencing to learn which gene mutations are present in a patient's tumor cells. The question is important because targeting the right mutations with the right drugs can stop cancer in its tracks. But it can be difficult to determine whether there is evidence in the medical literature that particular mutations might drive cancer growth and could be targeted by therapy, and which mutations are of no consequence.

27 Aug 2015

UCSF study reveals molecular timing mechanism of stem cells

UC San Francisco researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue.

27 Aug 2015

Awareness of mortality can be injurious to health, new research reveals

People with low self-esteem use a variety of escape mechanisms to avoid thinking about their own mortality, new research reveals. Researchers led by Dr Arnaud Wisman, of the University of Kent's School of Psychology, found evidence in five studies that people with low self-esteem respond to reminders of their own mortality by directing their focus away from the 'self'.

27 Aug 2015

Cosmetic and cleaning products contain millions of plastic particles

Everyday cosmetic and cleaning products contain huge quantities of plastic particles, which are released to the environment and could be harmful to marine life, according to a new study.

27 Aug 2015

Purple potatoes may help prevent colon cancer

Compounds found in purple potatoes may help kill colon cancer stem cells and limit the spread of the cancer, according to a team of researchers.

27 Aug 2015

Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana-Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine.

27 Aug 2015

GOSH to improve rare disease diagnosis with adoption of Congenica’s Sapientia technology

Ian was ‘a clumsy child’. He kept bumping into objects and couldn’t see well in the dark. He endured 15 years of tests and misdiagnoses during a lengthy, and sometimes traumatic, diagnostic odyssey.

26 Aug 2015

New research provides hope that women undergoing fertility treatment can avoid unpleasant hormonal gel

Since the early days of fertility treatment, women undergoing IVF treatment have had to place a hormonal gel in their vagina on a daily basis for at least 14 days after embryo transfer. The hormone is necessary to increase the chances of pregnancy, but it may also cause some side effects in the form of irritation and leaky discharge.

26 Aug 2015

Omega-3 supplements fail to slow cognitive decline in older persons, NIH clinical study shows

While some research suggests that a diet high in omega-3 fatty acids can protect brain health, a large clinical trial by researchers at the National Institutes of Health found that omega-3 supplements did not slow cognitive decline in older persons. With 4,000 patients followed over a five-year period, the study is one of the largest and longest of its kind.

26 Aug 2015

Kewaunee Scientific's sales up 2% in first quarter 2015

Kewaunee Scientific Corporation today reported results for its first quarter ended July 31, 2015.

26 Aug 2015

Better drug design may soon be aided by Scripps scientists’ discoveries

For the first time, they have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output. These new findings could aid future drug design by giving scientists an edge in fine tuning the signal between these partnered proteins—and the drug’s course of action.

25 Aug 2015

Sandia researchers develop nerve-like polymer network using biological mechanisms

Using a succession of biological mechanisms, Sandia National Laboratories researchers have created linkages of polymer nanotubes that resemble the structure of a nerve, with many out-thrust filaments poised to gather or send electrical impulses.

25 Aug 2015

New TSRI study may have important implications for better drug design

Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output. These new findings could aid future drug design by giving scientists an edge in fine tuning the signal between these partnered proteins—and the drug's course of action.

25 Aug 2015

Laboratory News and Research

Brainbow technique reveals surprising data about brain's visual circuitry

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

Study sheds further light on the way APOL1 protein kills trypanosmoe

New ORNL interface can identify, characterize solid or liquid sample

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

Researchers design online database to help researchers identify cancer gene mutations

UCSF study reveals molecular timing mechanism of stem cells

Awareness of mortality can be injurious to health, new research reveals

Cosmetic and cleaning products contain millions of plastic particles

Purple potatoes may help prevent colon cancer

Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

GOSH to improve rare disease diagnosis with adoption of Congenica’s Sapientia technology

New research provides hope that women undergoing fertility treatment can avoid unpleasant hormonal gel

Omega-3 supplements fail to slow cognitive decline in older persons, NIH clinical study shows

Kewaunee Scientific's sales up 2% in first quarter 2015

Better drug design may soon be aided by Scripps scientists’ discoveries

Sandia researchers develop nerve-like polymer network using biological mechanisms

New TSRI study may have important implications for better drug design

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