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Apixaban superior to enoxaparin in reducing venous thromboembolism in total knee replacement surgery patients

Apixaban, an oral anticoagulant being developed by Bristol-Myers Squibb Company and Pfizer Inc., was statistically superior to 40 mg once daily enoxaparin in reducing the incidence of venous thromboembolism in patients undergoing elective total knee replacement surgery, according to the ADVANCE-2 study results published today in The Lancet. The study results also showed numerically lower rates of major and clinically relevant non-major bleeding in patients treated with apixaban compared with those treated with enoxaparin.

5 Mar 2010

Gene involved in susceptibility and resistance to TB identified

University of Washington researchers have identified a gene involved in susceptibility and resistance to tuberculosis. This same gene, they have found, has a role in the severity of leprosy, which is caused by a related pathogen. The researchers also have learned why this gene is important for susceptibility.

5 Mar 2010

Argos Therapeutics' AGS-004 immunotherapy for HIV demonstrates clinical and commercial potential

Argos Therapeutics today announced the publication of a manuscript in the February edition of Clinical Immunology, detailing positive immune response, safety and manufacturing data for its AGS-004 immunotherapy for HIV. AGS-004 is a product of the Company’s Arcelis™ technology, and is a personalized, RNA-loaded dendritic cell-based immunotherapy that is perfectly matched to each patient’s unique HIV viral burden. The manuscript details a clinical study in which AGS-004 was evaluated in type-1 HIV-infected adults who were being treated with antiretroviral therapy (ART).

5 Mar 2010

Urinary catheterization of men and women: NAFC releases new consumer educational resource

The National Association For Continence (NAFC) has released a new consumer educational resource, focusing on catheterization procedures and care in the United States. The Urinary Catheterization of Men and Women pamphlet is the newest addition to NAFC's library of educational materials available to consumers seeking knowledge of management and treatment options for medical problems related to incontinence. It is also helpful as an educational supplement to nurses giving instructions to patients regarding their self-care.

4 Mar 2010

Phase III GOG-212 clinical trial of CTI's OPAXIO for ovarian cancer: Enrollment to continue

Cell Therapeutics, Inc. announced today that CTI received a statement on March 1, 2010 from the Gynecologic Oncology Group (GOG) leadership that the phase III GOG-212 clinical trial of CTI's OPAXIO™ used as maintenance therapy for ovarian cancer remains a high priority and enrollment will continue. The GOG made the statement to clarify that the recent results of the GOG-218 clinical trial bevacizumab in maintenance therapy for ovarian cancer has not influenced the importance of completing the GOG-212 clinical trial.

4 Mar 2010

HbA1c levels help predict future diabetes more accurately than fasting glucose measurements

Measurements of hemoglobin A1c (HbA1c) more accurately identify persons at risk for clinical outcomes than the commonly used measurement of fasting glucose, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health.

4 Mar 2010

Also in Global Health News: U.S. Ambassador to U.N.; Male circumcision; River blindness in Ecuador; Nursing shortage in Caribbean; Maternal health in Bolivia; Drug-resistant TB in North Korea; Cholera vaccine

Betty King reported to her new position as U.S. ambassador to the U.N. in Geneva on Wednesday, the Associated Press reports. "Washington's Geneva mission had been without an ambassador since Warren W. Tichenor left his post on Jan. 20, 2009 - when Barack Obama was sworn in as president," according to the news service (3/3).

4 Mar 2010

New federal guidelines on breast cancer screening: Stanford experts disagree

At a recent community education program, Stanford experts on women’s cancer disagreed with controversial new federal guidelines on breast cancer screening. The new guidelines, released in November by the U.S. Preventive Services Task Force, would delay a woman’s first mammogram by 10 years, reduce future screenings from annual to every other year, and end them after age 74.

4 Mar 2010

St. Jude Medical publishes clinical results of HOMEOSTASIS trial

St. Jude Medical, Inc. today announced publication of clinical results in the Hemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients (HOMEOSTASIS) trial.

4 Mar 2010

Older women with suspected ovarian cancer 'face referral delays'

Older women with suspected ovarian cancer are often not referred for investigation as quickly as younger women, new research suggests.

4 Mar 2010

Study: Salvage targeted therapy can be suitable for elderly patients with NSCLC

Research published in the March issue of the Journal of Thoracic Oncology sought to determine whether differences existed in tolerance and efficacy between patients age 70 and over and younger patients with non-small cell lung cancer (NSCLC) receiving salvage targeted therapy with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) or chemotherapy.

4 Mar 2010

Patients with confirmed episodes of consciousness during surgery have high rates of PTSD: Study

Patients with confirmed episodes of consciousness during surgery have high rates of psychological problems including posttraumatic stress disorder (PTSD), even several years after the incident, reports a study in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

4 Mar 2010

Shock: Norepinephrine favored over dopamine

Physicians treating patients with shock should consider norepinephrine instead of dopamine as a tool for stabilizing blood pressure, according to an editorial in the March 4, 2010, issue of the New England Journal of Medicine (NEJM).

3 Mar 2010

Spectral Diagnostics receives FDA IDE approval for Toraymyxin

BioMS Medical Corp. today reported that Spectral Diagnostics has received Investigational Device Exemption (IDE) approval from the U.S. Food and Drug Administration (FDA) for Toraymyxin(TM). Spectral Diagnostics and BioMS have entered into a services agreement whereby BioMS will assist Spectral, as required, in its commercialization of Toraymyxin(TM), a therapeutic hemoperfusion device for the treatment of severe sepsis. This approval permits Spectral to initiate its planned pivotal trial for Toraymyxin(TM) in the United States.

3 Mar 2010

Greater use of ESAs and iron at lower hematocrit levels decrease risk of death for hemodialysis patients

Greater use of erythropoiesis-stimulating agents (ESAs) and more frequent use of iron at lower hematocrit levels (the proportion of the blood that consists of red blood cells) was associated with a decreased risk of death for hemodialysis patients, according to a study in the March 3 issue of JAMA.

3 Mar 2010

Aggressive treatment of anemia with ESAs may lower risk of death for dialysis patients: Study

Aggressive treatment of anemia with intravenous iron and drugs known as erythropoiesis-stimulating agents (ESAs) may lower the risk of death for dialysis patients with severe anemia - but also may increase the risk of death among patients with milder anemia, a new study led by a University of North Carolina at Chapel Hill epidemiologist suggests.

3 Mar 2010

Physician experts to help provide perspective on many options for colorectal cancer screening

Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them.

3 Mar 2010

Opinions: Chile's preparedness; Evangelical Christians; 'Locavorism'

The earthquake in Chile "was the fifth biggest ever measured, and several hundred times larger than the one that killed more than 220,000 in Haiti," according to a Wall Street Journal editorial. The editorial highlights Chile's preparation for earthquakes, including stricter building codes. "But such preparation is also the luxury of a prosperous country, in contrast to destitute and ill-governed Haiti.

3 Mar 2010

Adult day health programs help senior participants maintain their health and independence

A recent study by San Francisco’s Institute on Aging documents that adult day health programs play a vital role in helping senior participants maintain their health and independence. Since the 1970s, adult day health care has been promoted as an alternative to nursing home care for seniors with chronic illness, disability, or dementia.

3 Mar 2010

U.N. meeting examines progress, challenges in achieving women's empowerment

Despite gains in women's rights in the 15 years since the Beijing Declaration, U.N. Female Deputy Secretary-General Asha-Rose Migiro on Monday during the opening of the U.N. Commission on the Status of Women (CSW) meeting acknowledged more action is needed to help countries advance gender equality and women's empowerment, VOA News reports.

3 Mar 2010

Mortality News and Research

Apixaban superior to enoxaparin in reducing venous thromboembolism in total knee replacement surgery patients

Gene involved in susceptibility and resistance to TB identified

Argos Therapeutics' AGS-004 immunotherapy for HIV demonstrates clinical and commercial potential

Urinary catheterization of men and women: NAFC releases new consumer educational resource

Phase III GOG-212 clinical trial of CTI's OPAXIO for ovarian cancer: Enrollment to continue

HbA1c levels help predict future diabetes more accurately than fasting glucose measurements

Also in Global Health News: U.S. Ambassador to U.N.; Male circumcision; River blindness in Ecuador; Nursing shortage in Caribbean; Maternal health in Bolivia; Drug-resistant TB in North Korea; Cholera vaccine

New federal guidelines on breast cancer screening: Stanford experts disagree

St. Jude Medical publishes clinical results of HOMEOSTASIS trial

Older women with suspected ovarian cancer 'face referral delays'

Study: Salvage targeted therapy can be suitable for elderly patients with NSCLC

Patients with confirmed episodes of consciousness during surgery have high rates of PTSD: Study

Shock: Norepinephrine favored over dopamine

Spectral Diagnostics receives FDA IDE approval for Toraymyxin

Greater use of ESAs and iron at lower hematocrit levels decrease risk of death for hemodialysis patients

Aggressive treatment of anemia with ESAs may lower risk of death for dialysis patients: Study

Physician experts to help provide perspective on many options for colorectal cancer screening

Opinions: Chile's preparedness; Evangelical Christians; 'Locavorism'

Adult day health programs help senior participants maintain their health and independence

U.N. meeting examines progress, challenges in achieving women's empowerment

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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