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Many phase II trials overestimate drug efficacy, pose a barrier in drug licensing

Based on a systematic analysis of trials related to rheumatoid arthritis and psoriasis arthritis, a MedUni Vienna study group at the Division of Rheumatology at MedUni Vienna/Vienna General Hospital was able to show that many clinical phase II trials systematically overestimate the efficacy of therapeutics, so that the results of subsequent phase III trials can often be disappointing. Essentially this situation also applies in many other areas.

21 Apr 2020

New computational model shows how psilocybin affects brain activity

Interest in research into the effects of psilocybin, a psychedelic drug, has increased significantly in recent years due to its promising therapeutic effects in neuropsychiatric disorders such as depression, anxiety and addiction.

17 Apr 2020

Gimsilumab trial starts in first US patient with ARDS and COVID-19

The first American patient with COVID-19 and acute respiratory distress syndrome (ARDS) has been put on the drug gimsilumab at Temple University Hospital, as part of the BREATHE clinical trial. The trial, sponsored by Roivant Sciences, will evaluate the effectiveness of intravenous gimsilumab in preventing death in patients with COVID-19 and ARDS.

16 Apr 2020

Remdesivir drug stops novel coronavirus from replicating

Scientists from the University of Alberta have published findings that the antiviral drug remdesivir prevents replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by inhibiting RNA replication. The study, published in April 2020 in the Journal of Biological Chemistry, follows on the heels of earlier reports from the same lab in February, showing the drug's effectiveness against the related Middle East Respiratory Syndrome (MERS) virus.

15 Apr 2020

New vaccine for Chikungunya reported safe and well-tolerated

A virus-like particle vaccine was shown to be safe and well-tolerated among a healthy adult population living in chikungunya endemic areas, the researchers report in a new study published in the Journal of the American Medical Association (JAMA).

14 Apr 2020

Intermountain Healthcare and University of Utah Health launch two COVID-19 clinical trials

Researchers from Intermountain Healthcare and University of Utah Health in Salt Lake City have launched two vital clinical trials to test the effectiveness and safety of two drugs - hydroxychloroquine and azithromycin - to treat patients with COVID-19.

13 Apr 2020

Remdesivir shows promise in post-infection treatment for COVID-19 disease

The coronavirus disease (COVID-19) has no approved treatment or vaccine as the world grapple with its wrath. The viral infection has so far infected 1.8 million and killed more than 114,000 people. Now, a team of scientists has shown that an experimental antiviral drug, remdesivir, has shown promise in treating patients with severe COVID-19.

13 Apr 2020

Novel clinical trial fast tracks testing of COVID-19 therapies

A novel clinical trial developed by researchers at the University of Pittsburgh School of Medicine launched today at UPMC to address one of the most important debates during the COVID-19 pandemic:

9 Apr 2020

Bright light therapy can be effective treatment for seasonal affective disorder

An analysis published in Psychotherapy and Psychosomatics documents the value of light therapy in treating seasonal affective disorder.

9 Apr 2020

University of Utah Health, Intermountain Healthcare launch two clinical trials to treat COVID-19 patients

Researchers from Intermountain Healthcare and University of Utah Health in Salt Lake City have launched two vital clinical trials to test the effectiveness and safety of two drugs -hydroxychloroquine (HCQ) and azithromycin - to treat patients with COVID-19 (infection with the novel coronavirus).

9 Apr 2020

Metastatic bladder cancer significantly slowed by treating with immunotherapy after chemotherapy

Using immunotherapy immediately after chemotherapy in patients with metastatic bladder cancer slowed cancer progression.

9 Apr 2020

Discovery of key protein may lead to more effective treatments for depression

Depression is a common psychiatric disorder and one of the leading causes of disability worldwide. Antidepressants are the first-line treatment for moderate to severe major depressive episodes.

9 Apr 2020

Penn-led trial to evaluate the effectiveness of HCQ in combating COVID-19 pandemic

A new trial led by the Perelman School of Medicine at the University of Pennsylvania will evaluate whether the drug hydroxychloroquine can benefit people infected with COVID-19, as well as whether taking the drug preventatively may help people avoid infection altogether.

6 Apr 2020

‘You pray that you got the drug.’ Ailing couple gambles on trial for COVID-19 cure

For 10 days last month, they lay in side-by-side isolation units in a Seattle-area hospital, tethered to oxygen and struggling to breathe as the coronavirus ravaged their lungs.

6 Apr 2020

Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

Montefiore Health System and Albert Einstein College of Medicine has joined a clinical trial to evaluate the experimental drug remdesivir to treat people who are hospitalized with severe COVID-19 infection.

5 Apr 2020

Immunosuppressant shows promise in addressing COVID-19 symptoms for patients with blood cancers

A case study of a patient in Wuhan, China, suggests that the immunosuppressant tocilizumab may be an effective COVID-19 treatment for very ill patients who also have multiple myeloma and other blood cancers.

5 Apr 2020

Magnetic stimulation of rectal nerves could help treat fecal incontinence

An ongoing study by the Medical College of Georgia on the role of magnetic stimulation of the rectal nerves to achieve better bowel control in patients with fecal incontinence is showing early promise. The technique is called translumbosacral neuromodulation therapy, or TNT.

2 Apr 2020

UIC participates in two clinical trials for COVID-19 treatments

The University of Illinois at Chicago is participating in two clinical trials for COVID-19 treatments.

2 Apr 2020

Duke to lead PCORI-funded study of COVID-19 prevention in healthcare workers

The Patient-Centered Outcomes Research Institute has funded up to $50 million to evaluate hydroxychloroquine (HCQ) as a preventive drug for the novel coronavirus.

1 Apr 2020

PCORI funds $50 million to study HCQ's effectiveness in preventing COVID-19 in healthcare workers

The Patient-Centered Outcomes Research Institute Board of Governors today approved up to $50 million to fund a registry and randomized clinical trial of the effectiveness of hydroxychloroquine in preventing COVID-19 infections in U.S. healthcare workers.

1 Apr 2020

Placebo News and Research

Many phase II trials overestimate drug efficacy, pose a barrier in drug licensing

New computational model shows how psilocybin affects brain activity

Gimsilumab trial starts in first US patient with ARDS and COVID-19

Remdesivir drug stops novel coronavirus from replicating

New vaccine for Chikungunya reported safe and well-tolerated

Intermountain Healthcare and University of Utah Health launch two COVID-19 clinical trials

Remdesivir shows promise in post-infection treatment for COVID-19 disease

Novel clinical trial fast tracks testing of COVID-19 therapies

Bright light therapy can be effective treatment for seasonal affective disorder

University of Utah Health, Intermountain Healthcare launch two clinical trials to treat COVID-19 patients

Metastatic bladder cancer significantly slowed by treating with immunotherapy after chemotherapy

Discovery of key protein may lead to more effective treatments for depression

Penn-led trial to evaluate the effectiveness of HCQ in combating COVID-19 pandemic

‘You pray that you got the drug.’ Ailing couple gambles on trial for COVID-19 cure

Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

Immunosuppressant shows promise in addressing COVID-19 symptoms for patients with blood cancers

Magnetic stimulation of rectal nerves could help treat fecal incontinence

UIC participates in two clinical trials for COVID-19 treatments

Duke to lead PCORI-funded study of COVID-19 prevention in healthcare workers

PCORI funds $50 million to study HCQ's effectiveness in preventing COVID-19 in healthcare workers

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