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Change of fatty diet can cause feelings like drug withdrawal and depression

Even before obesity occurs, eating fatty and sugary foods causes chemical changes in the brain, meaning that going on a diet might feel similar to going through drug withdrawal, according to a study published today by Dr. Stephanie Fulton of the University of Montreal's Faculty of Medicine and its affiliated CRCHUM Hospital Research Centre.

13 Dec 2012

GM604 target regulates over 4,000 genes: Genervon

Genervon scientists have confirmed that the target of GM604 regulates over 4,000 genes. More significantly, it modifies ALS disease progression by modulating at least 30 significant ALS related genes. It does this through at least 8 pathways, potentially more, and up to 22 biological processes.

13 Dec 2012

Study focuses on nontraditional lifestyle of Retinoblastoma tumor suppressor proteins

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.

13 Dec 2012

Study finds many patients with family history of LINE-1 hypomethylated colorectal cancer

When people with a family history of colorectal cancer develop the disease, their tumors often carry a molecular sign that the cancer could be life-threatening and may require aggressive treatment, Dana-Farber Cancer Institute scientists report in a new study.

13 Dec 2012

Delayed childbearing may protect against triple-negative breast cancer

Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study.

12 Dec 2012

TKI-resistant human leukemia stem cells are the source of genomic instability

An international team of scientists, led by researchers from Temple University School of Medicine, has found that a source of mounting genomic chaos, or instability, common to chronic myeloid leukemia (CML) may lie in a pool of leukemia stem cells that are immune to treatment with potent targeted anticancer drugs.

12 Dec 2012

Review describes current state of lung cancer care

A review in the December issue of the journal Archives of Pathology & Laboratory Medicine by Paul Bunn Jr, MD, University of Colorado Cancer Center investigator and past president of ASCO, IASLC and AACI describes the current state of lung cancer care.

12 Dec 2012

Ancient algae may hold key to treating malaria and related parasites

Researchers have discovered that parasites of the Apicomplexa taxon, such as Plasmodium falciparum and Toxoplasma gondii, reproduce within host cells using a structure that evolved from a flagellum.

12 Dec 2012

Scientists determine specific genetic switches that sync liver activity to the circadian cycle

When it's dark, and we start to fall asleep, most of us think we're tired because our bodies need rest. Yet circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes.

12 Dec 2012

Link between CTNNA3 gene mutations and arrhythmogenic right ventricular cardiomyopathy

Unfortunately, newspaper articles about young athletes dying suddenly on the field are not unheard of. Such reports fuel discussions about compulsory screening, for example of young footballers, for heart failure. Research by scientists from Ghent (VIB/UGent) and Italy will benefit these screening methods.

12 Dec 2012

Epi-marks can lead to homosexuality

Epigenetics - how gene expression is regulated by temporary switches, called epi-marks - appears to be a critical and overlooked factor contributing to the long-standing puzzle of why homosexuality occurs.

12 Dec 2012

SIRT6 protein may play a critical role in blocking cancer and controlling cellular metabolism

A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows.

11 Dec 2012

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

11 Dec 2012

Nature, nurture appear to be significant factors in early antisocial behaviors of adopted children

Both nature and nurture appear to be significant factors in early antisocial behaviors of adopted children, a Wayne State University researcher believes.

11 Dec 2012

Pfizer's PD0325901 experimental drug blocks untreatable NF1 tumors

Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1).

11 Dec 2012

Bolstering extracellulal matrix prevents skin aging

As we get older, the trillions of cells in our body do too. And like us, they become less resilient and able to weather the stress of everyday life. Our skin especially tells the tale of what's happening throughout our bodies.

11 Dec 2012

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

11 Dec 2012

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

Fred Hutchinson Cancer Research Center and GlaxoSmithKline PLC (GSK) today announced a partnership to develop therapeutics to treat an inherited form of muscular dystrophy.

11 Dec 2012

UNM study to understand why and how DNA repair mechanisms go awry in cancer cells

DNA, like houses and cars, needs ongoing maintenance. Rays of ultraviolet sunlight, chemical pollutants and normal biochemical processes in the cell can damage it. Cells routinely repair this damage before making proteins or copying DNA for cell division. The repairs are remarkably accurate in normal cells but cancer cells make far more mistakes in fixing their DNA.

11 Dec 2012

Boston College professor to research into new drugs that can prevent onset of toxoplasmosis

The American Cancer Society has awarded a four-year, $720,000 grant to Boston College Associate Professor of Biology Marc-Jan Gubbels for research into potential new drugs that can prevent the onset of toxoplasmosis in cancer patients with weakened immune systems.

10 Dec 2012

Genes News and Research

Change of fatty diet can cause feelings like drug withdrawal and depression

GM604 target regulates over 4,000 genes: Genervon

Study focuses on nontraditional lifestyle of Retinoblastoma tumor suppressor proteins

Study finds many patients with family history of LINE-1 hypomethylated colorectal cancer

Delayed childbearing may protect against triple-negative breast cancer

TKI-resistant human leukemia stem cells are the source of genomic instability

Review describes current state of lung cancer care

Ancient algae may hold key to treating malaria and related parasites

Scientists determine specific genetic switches that sync liver activity to the circadian cycle

Link between CTNNA3 gene mutations and arrhythmogenic right ventricular cardiomyopathy

Epi-marks can lead to homosexuality

SIRT6 protein may play a critical role in blocking cancer and controlling cellular metabolism

CYP2J2 implicated in preeclampsia

Nature, nurture appear to be significant factors in early antisocial behaviors of adopted children

Pfizer's PD0325901 experimental drug blocks untreatable NF1 tumors

Bolstering extracellulal matrix prevents skin aging

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

UNM study to understand why and how DNA repair mechanisms go awry in cancer cells

Boston College professor to research into new drugs that can prevent onset of toxoplasmosis

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