Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

FDA approved drug found to have anti-cancer activity against previously unknown targets

Developing new drugs to treat cancer can be a painstaking process taking over a decade from start to Food and Drug Administration approval. Scientists are trying to develop innovative strategies to identify and test new drugs quicker and more efficiently.

10 Oct 2017

Scientists identify potential treatment target for diabetic retinopathy

In oxygen-compromising conditions like diabetes, the body grows new blood vessels to help, but the result is often leaky, dysfunctional vessels that make bad matters worse.

10 Oct 2017

PAA launches new S-LAB automated plate handler at ELRIG Drug Discovery

Peak Analysis & Automation, a global leader in laboratory automation, announces the launch of its S-LAB automated plate handler on stand B15 at ELRIG Drug Discovery, ACC Liverpool, October 3-4th 2017.

4 Oct 2017

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Osaka Researchers, in partnership with other Japanese and U.S. scientists, report a new gene target, KPNB1, for treatment against epithelial ovarian cancer (EOC).

28 Sep 2017

Understanding molecular mechanisms and metabolic pathways of yeast for drug discovery

My research uses budding yeast as a tool for synthetic biology, and also in chemical and functional genomic applications. We are interested in understanding molecular mechanisms and metabolic pathways of yeast for drug discovery.

From Tecan 27 Sep 2017

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.

26 Sep 2017

Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

Chagas disease is a potentially life-threatening illness caused by the parasite, Trypanosoma cruzi, and is transmitted to humans through triatomine blood-sucking bugs that are commonly referred to as "kissing bugs" or "vampire bugs".

26 Sep 2017

New pig model for stroke could accelerate drug discovery process

It is well-known in the medical field that the pig brain shares certain physiological and anatomical similarities with the human brain. So similar are the two that researchers at the University of Georgia's Regenerative Bioscience Center have developed the first U.S. pig model for stroke treatments, which will provide essential preclinical data and speed the drug discovery process.

26 Sep 2017

Advanced technique could pave way for cascade of new steroidal therapeutics

Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process, published in the journal Nature Chemistry, facilitates access to rare, mirror-image isomers of naturally occurring steroid structures.

26 Sep 2017

Researchers design novel small antibody fragment with improved crystallizability

Antibodies are a powerful weapon system in defending our body against invaders such as bacteria and viruses. Each antibody consists of four polypeptide chains: two heavy chains and two light chains joined to form a Y-shaped molecule.

21 Sep 2017

New collaboration could lead to novel drugs that address unmet medical needs

Southern Research and the University of Tennessee Health Science Center have formed a partnership to advance promising research that could lead to new drugs that address unmet medical needs.

20 Sep 2017

Porvair Sciences provide optimised microplate products for drug discovery scientists

Porvair Sciences offers a range of application optimised microplates and high-performance microplate equipment designed to enable drug discovery scientists to optimise sample preparation and improve productivity.

From Porvair Sciences Limited 15 Sep 2017

Genestack provides missing link between data and analysis for drug discovery

“Genestack is providing an essential missing link between data and its analysis,” says Imad I. Yassin, recently appointed Vice President of Sales and Marketing for Genestack, the Cambridge-based biodata management company.

13 Sep 2017

Virginia Tech research provides new mechanistic insights into health benefits of olives and olive oil

The health benefits of olives-- and associated natural products such as olive oil--have long been recognized and touted by proponents of the Mediterranean diet.

13 Sep 2017

‘Nanoswitches’ could be key to faster, more sensitive tests for detection of biomarkers

Engineered strands of DNA -- nanoscale tools called "nanoswitches" -- could be the key to faster, easier, cheaper and more sensitive tests that can enable high-fidelity detection of biomarkers indicating the presence of different diseases, viral strains and even genetic variabilities as subtle as a single-gene mutation.

12 Sep 2017

VUMC and Bayer agree on strategic research alliance to develop new therapies for kidney diseases

Vanderbilt University Medical Center and Bayer have agreed on a five-year strategic research alliance to evaluate new drug candidates for the treatment of kidney diseases, with the goal of accelerating the translation of innovative approaches from the laboratory to pre-clinical development.

12 Sep 2017

PXi multi-application imager used for new fluorescent peptide imaging application

Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce its PXi multi-application imager is being used by scientists at the prestigious Freie Universtät Berlin for the new application of imaging fluorescent peptides on Western blots.

From Syngene 8 Sep 2017

New crowdfunding campaign aims to develop, test novel photographic biomarkers of aging in mice

The Biogerontology Research Foundation announces the launch of a crowdfunding campaign, MouseAge, to develop and test photographic biomarkers of ageing in mice in collaboration with scientists from Harvard University, University of Oxford, Youth Laboratories and Insilico Medicine.

31 Aug 2017

St. Jude creates world’s largest collection of pediatric solid tumor samples

In an effort to improve outcomes for patients with some of the deadliest childhood cancers, St. Jude Children's Research Hospital scientists have created the world's largest collection of pediatric solid tumor samples, drug-sensitivity data and related information and have made the resource available at no charge to the global scientific community.

31 Aug 2017

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

26 Aug 2017

Drug Discovery News and Research

Further Reading

FDA approved drug found to have anti-cancer activity against previously unknown targets

Scientists identify potential treatment target for diabetic retinopathy

PAA launches new S-LAB automated plate handler at ELRIG Drug Discovery

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Understanding molecular mechanisms and metabolic pathways of yeast for drug discovery

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

New pig model for stroke could accelerate drug discovery process

Advanced technique could pave way for cascade of new steroidal therapeutics

Researchers design novel small antibody fragment with improved crystallizability

New collaboration could lead to novel drugs that address unmet medical needs

Porvair Sciences provide optimised microplate products for drug discovery scientists

Genestack provides missing link between data and analysis for drug discovery

Virginia Tech research provides new mechanistic insights into health benefits of olives and olive oil

‘Nanoswitches’ could be key to faster, more sensitive tests for detection of biomarkers

VUMC and Bayer agree on strategic research alliance to develop new therapies for kidney diseases

PXi multi-application imager used for new fluorescent peptide imaging application

New crowdfunding campaign aims to develop, test novel photographic biomarkers of aging in mice

St. Jude creates world’s largest collection of pediatric solid tumor samples

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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