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Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Researchers discovered that venom toxins from African spitting cobras cause severe dermonecrosis, highlighting the need for targeted treatments like the repurposed drug varespladib.

9 May 2024

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

A team led by the Duke Human Vaccine Institute (DHVI) has developed a vaccine approach that works like a GPS, guiding the immune system through the specific steps to make broadly neutralizing antibodies against HIV.

9 May 2024

Researchers create the largest 3D reconstruction of human brain fragment

A cubic millimeter of brain tissue may not sound like much. But considering that tiny square contains 57,000 cells, 230 millimeters of blood vessels, and 150 million synapses, all amounting to 1,400 terabytes of data, Harvard and Google researchers have just accomplished something enormous.

9 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Experts identify highly drug-resistant infections from stem cell treatments In Mexico

Experts in mycobacterial diseases at National Jewish Health, in collaboration with local health departments and the Centers for Disease Control and Prevention (CDC), are investigating a potential outbreak of a highly drug-resistant mycobacterium (germ) after U.S. patients who traveled to Mexico for stem cell injections became sick.

9 May 2024

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Modified ketogenic diet modulates gut microbiome, inflammatory markers, and brain-related miRNAs in autistic children, correlating with improved behavioral symptoms. The diet increases beneficial gut bacteria and reduces inflammatory cytokines and BDNF levels.

9 May 2024

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Alcohol exposure leads to accumulation of oxidatively damaged proteins in neuronal cells. Differentiated cells are more susceptible to alcohol-induced oxidative protein damage despite higher resistance to cytotoxicity.

9 May 2024

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

Mouse-rat chimeras offer functional liver cells for transplantation

Liver disease, due to viral infections, alcohol abuse, obesity, or cancer, accounts for 1 in every 25 deaths worldwide.

9 May 2024

Deep learning models for predicting prostate cancer recurrence risk from 3D pathology datasets

Human tissue is intricate, complex and, of course, three dimensional. But the thin slices of tissue that pathologists most often use to diagnose disease are two dimensional, offering only a limited glimpse at the tissue's true complexity.

9 May 2024

Exploring microbiome dynamics in esophageal cancer

Esophageal cancer (EC) has two primary subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Understanding aging through stochastic changes in cells

Aging clocks can measure the biological age of humans with high precision. Biological age can be influenced by environmental factors such as smoking or diet, thus deviating from the chronological age that is calculated using the date of birth.

9 May 2024

New modular epigenome editing platform sheds light on gene regulation mechanisms

Understanding how genes are regulated at the molecular level is a central challenge in modern biology.

9 May 2024

UT Health San Antonio leads effort for developing oral vaccine against chlamydia

The study of a novel oral vaccine that could protect against chlamydia infection has been awarded approximately $11 million in National Institutes of Health funding over five years through a cooperative agreements research project grant, known as a U01 grant.

9 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

Cross-species liver cell growth could represent a solution to transplant shortage

Liver disease, due to viral infections, alcohol abuse, obesity, or cancer, accounts for 1 in every 25 deaths worldwide.

8 May 2024

USC study unveils iron as key driver of lung inflammation in allergic asthma

New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack – and blocking or limiting iron may reduce the severity of symptoms.

8 May 2024

Researchers enhance CAR-T cells to target solid tumors

Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors-;an advance that could transform cancer treatment.

8 May 2024

Freshness matters: Study finds newer honey packs a stronger antibacterial punch

Researchers reveal that the antibacterial potency of Hungarian honeys, including their effectiveness against respiratory pathogens, declines with storage time, emphasizing the need for fresh sources in medical applications.

8 May 2024

Cell News and Research

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

Researchers create the largest 3D reconstruction of human brain fragment

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Experts identify highly drug-resistant infections from stem cell treatments In Mexico

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

Mouse-rat chimeras offer functional liver cells for transplantation

Deep learning models for predicting prostate cancer recurrence risk from 3D pathology datasets

Exploring microbiome dynamics in esophageal cancer

Enhancing the ability of natural killer cells to combat hematologic malignancies

Understanding aging through stochastic changes in cells

New modular epigenome editing platform sheds light on gene regulation mechanisms

UT Health San Antonio leads effort for developing oral vaccine against chlamydia

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Cross-species liver cell growth could represent a solution to transplant shortage

USC study unveils iron as key driver of lung inflammation in allergic asthma

Researchers enhance CAR-T cells to target solid tumors

Freshness matters: Study finds newer honey packs a stronger antibacterial punch

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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