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Enzyme implicated in telomere repair offers new avenues for cancer therapy

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.

7 May 2024

Parental monitoring key to preventing teenagers' substance use

Teenagers are less likely to drink, smoke or use drugs when their parents keep tabs on their activities--but not necessarily because kids are more likely to be punished for substance use, suggests a new study in the Journal of Studies on Alcohol and Drugs.

7 May 2024

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary.

7 May 2024

What’s keeping the US from allowing better sunscreens?

When dermatologist Adewole "Ade" Adamson sees people spritzing sunscreen as if it's cologne at the pool where he lives in Austin, Texas, he wants to intervene.

7 May 2024

Innovative nanoparticle breaks blood-brain barrier to target breast cancer and brain metastases

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier.

6 May 2024

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder.

6 May 2024

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

Qi "Tony" Zhou, a researcher in Purdue University's College of Pharmacy has received a $2.4 million grant from the National Institutes of Health to fight lung infections that have established a resistance to antimicrobial drugs.

6 May 2024

UC San Diego's open source AI platform revolutionizes multi-target drug discovery

Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen treatments.

6 May 2024

Efficient intranasal delivery of agomelatine via micellar encapsulation

Announcing a new publication for Acta Materia Medica journal. Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution.

6 May 2024

Two studies aim to fight cancer with artificial cells

Fighting cancer with artificial cells that are capable of detecting and treating it. This is the dual objective of a research team of the Department of Cellular, Computational and Integrative Biology - Cibio of UniTrento, which has recently started two European projects funded by the Horizon Europe - EIC Pathfinder Open program.

6 May 2024

Could better inhalers help patients, and the planet?

Miguel Divo, a lung specialist at Brigham and Women's Hospital in Boston, sits in an exam room across from Joel Rubinstein, who has asthma. Rubinstein, a retired psychiatrist, is about to get a checkup and hear a surprising pitch — for the planet, as well as his health.

6 May 2024

Price inflation tied to higher mental health service utilization among adults and elderly in England

The relationship between price elevation and psychiatric care in the British population.

6 May 2024

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

Genomics plc and GSK announced a new collaboration to explore the potential for using polygenic risk scores (PRS) in clinical trials, to improve understanding of disease risk and patient selection, which could support optimization of trial design.

6 May 2024

Breast Cancer Now funds new research to investigate how breast cancer cells survive and grow

Researchers in Sheffield are investigating how breast cancer cells survive and grow, thanks to new funding from Breast Cancer Now.

6 May 2024

Natural compounds in gut microbiome show promise for inflammation treatment

Researchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues.

3 May 2024

NK cells' role in cancer therapy resistance unveiled

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system.

3 May 2024

Study provides deeper understanding of how membrane remodeling works in human cells

In a study published in the prestigious scientific journal PNAS, Umeå researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell.

3 May 2024

New discovery offers dietary solution for pulmonary hypertension

Blood vessels in the lungs aren't like the others in the body. This difference becomes clear in pulmonary hypertension, in which only the lungs' blood vessels stiffen progressively, leading to chronic lung disease, heart failure and death.

2 May 2024

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024

KFF Health News' 'What the Health?': Abortion access changing again in Florida and Arizona

The national abortion landscape was shaken again this week as Florida's six-week abortion ban took effect.

2 May 2024

Drugs News and Research

Enzyme implicated in telomere repair offers new avenues for cancer therapy

Parental monitoring key to preventing teenagers' substance use

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

What’s keeping the US from allowing better sunscreens?

Innovative nanoparticle breaks blood-brain barrier to target breast cancer and brain metastases

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

UC San Diego's open source AI platform revolutionizes multi-target drug discovery

Efficient intranasal delivery of agomelatine via micellar encapsulation

Two studies aim to fight cancer with artificial cells

Could better inhalers help patients, and the planet?

Price inflation tied to higher mental health service utilization among adults and elderly in England

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

Breast Cancer Now funds new research to investigate how breast cancer cells survive and grow

Natural compounds in gut microbiome show promise for inflammation treatment

NK cells' role in cancer therapy resistance unveiled

Study provides deeper understanding of how membrane remodeling works in human cells

New discovery offers dietary solution for pulmonary hypertension

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

KFF Health News' 'What the Health?': Abortion access changing again in Florida and Arizona

Drug Discovery - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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