Cell Biology

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Protein identified as promising novel obesity treatment

This week Amgen published data showing that injection of a protein known as growth differentiation factor 15 (GDF15) facilitated weight loss in obese mice and primates.

20 Oct 2017

Scientists uncover surprising molecular link in critical cellular growth pathway

A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth.

19 Oct 2017

Genetic diversity plays major role in evolution of drug resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists at the Wellcome Trust Sanger Institute and the Institute for Research on Cancer and Ageing of Nice in France, show that high genetic diversity can prime new mutations that cause drug resistance.

17 Oct 2017

Using AFM to study cell mechanics and function

My lab, broadly speaking, is interested in trying to understand interactions between cells and materials. Those could be materials that are present within living tissue or materials that we use for engineering purposes to try to do something of technological or therapeutic interest.

From Bruker Nano Surfaces and Metrology 17 Oct 2017

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Scientists at Columbia's Zuckerman Institute today received a grant from the Chan Zuckerberg Initiative donor advised fund, an advised fund of the Silicon Valley Community Foundation, to construct an atlas of gene activity of all cells in the human spinal cord.

17 Oct 2017

Investigating new cancer therapy candidates with live-cell imaging

There are two main things that we've worked on in the lab as regards to drug studies. One is identifying new combinations of drugs, and working on why a combination of drugs should work better than each alone.

From Sartorius 16 Oct 2017

Specific regions of silenced DNA help define cell's identity, study suggests

The fundamental mechanisms governing how cells form an identity such as becoming a muscle cell or a nerve cell are not fully understood. Multiple diseases, including cancer, have been linked to cells going down the wrong developmental path during maturation.

13 Oct 2017

New model predicts how E. coli bacteria respond to temperature changes, genetic mutations

Researchers at the University of California San Diego have developed a genome-scale model that can accurately predict how E. coli bacteria respond to temperature changes and genetic mutations.

13 Oct 2017

New x-ray analysis methodology reveals structure of disordered protein

Scientists at The University of Notre Dame have shown that disordered proteins have a structure very close to what would be expected for a truly random structure using a novel X-ray scattering (SAXS) analysis methodology.

13 Oct 2017

Researchers use mixed realty viewer to visualize complex biological networks in 3D

They call it the "hairy ball." It's an unflattering name for two-dimensional representations of a complex biological network, a depiction of a system of linkages and connections so complex and dense that "it looks like a big mess," said Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute and director of the university's bioinformatics and computational biology program.

13 Oct 2017

Research expands range in dry preservation of mammalian sperm cells

In a paper forthcoming in the November issue of the journal Theriogenology, a team of researchers from the University of North Carolina at Charlotte and the Smithsonian Conservation Biology Institute, announced the first successful drying and rehydration of domestic cat spermatozoa using a rapid microwave dehydration method.

12 Oct 2017

Scientists find new way to produce brain cells from single iPSC

Li Gan, PhD, wants to find treatments to help patients with Alzheimer's disease. Like most researchers, she's hit a few major roadblocks.

10 Oct 2017

New computer program identifies different cell types based on gene expression patterns

"How many different cell types are there in a human body? And how do these differences develop? Nobody really knows," says Professor Stein Aerts from KU Leuven and VIB, Belgium. But thanks to a new method developed by his team, that may be about to change.

10 Oct 2017

Newly discovered compound causes cancer cell death, whilst sparing healthy cells

Researchers have discovered a compound that can trigger cancer cells to self-destruct, without causing any damage to healthy cells.

10 Oct 2017

UCLA researchers develop new method to rapidly measure cell's stiffness and size

UCLA biophysicists have developed a new method to rapidly determine a single cell's stiffness and size -- which could ultimately lead to improved treatments for cancer and other diseases.

4 Oct 2017

Scientists manipulate living cells to produce fluorinated bioplastics

Natural organic compounds that contain fluorine are rare because living organisms—with a few exceptions—do not produce them.

4 Oct 2017

Zinc may help stop growth of esophageal cancer

Researchers at the University of Texas at Arlington have discovered that zinc targets and blocks a specific calcium channel in esophageal cancer cells, preventing them from proliferating.

2 Oct 2017

Benefits of Biomarkers in Colorectal Cancer Treatment

Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.

2 Oct 2017

Researchers develop new method to create endocytosis on demand

A solution to the problem of creating endocytosis on demand is being compared to 'hotwiring' a car. A team at Warwick Medical School, University of Warwick, has managed to trigger clathrin-mediated endocytosis in the lab. They did it by using a chemical rapamycin which diffuses in to the cell allowing them to trigger endocytosis to occur all over the cell.

28 Sep 2017

Understanding molecular mechanisms and metabolic pathways of yeast for drug discovery

My research uses budding yeast as a tool for synthetic biology, and also in chemical and functional genomic applications. We are interested in understanding molecular mechanisms and metabolic pathways of yeast for drug discovery.

From Tecan 27 Sep 2017

Cell Biology

Protein identified as promising novel obesity treatment

Scientists uncover surprising molecular link in critical cellular growth pathway

Genetic diversity plays major role in evolution of drug resistance

Using AFM to study cell mechanics and function

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Investigating new cancer therapy candidates with live-cell imaging

Specific regions of silenced DNA help define cell's identity, study suggests

New model predicts how E. coli bacteria respond to temperature changes, genetic mutations

New x-ray analysis methodology reveals structure of disordered protein

Researchers use mixed realty viewer to visualize complex biological networks in 3D

Research expands range in dry preservation of mammalian sperm cells

Scientists find new way to produce brain cells from single iPSC

New computer program identifies different cell types based on gene expression patterns

Newly discovered compound causes cancer cell death, whilst sparing healthy cells

UCLA researchers develop new method to rapidly measure cell's stiffness and size

Scientists manipulate living cells to produce fluorinated bioplastics

Zinc may help stop growth of esophageal cancer

Benefits of Biomarkers in Colorectal Cancer Treatment

Researchers develop new method to create endocytosis on demand

Understanding molecular mechanisms and metabolic pathways of yeast for drug discovery

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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