Cell Biology

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Research uncovers new insights into neuronal aging and rejuvenation

When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal aging — inevitable with the passing of time — is particularly accelerated and becomes a risk factor in neurodegenerative pathologies such as Alzheimer's disease.

24 Oct 2024

Study identifies key blood stem cells in immune system aging

What keeps some immune systems youthful and effective in warding off age-related diseases? In a new paper published in Cellular & Molecular Immunology, USC Stem Cell scientist Rong Lu and her collaborators point the finger at a small subset of blood stem cells, which make an outsized contribution to maintaining either a youthful balance or an age-related imbalance of the two main types of immune cells: innate and adaptive.

24 Oct 2024

Researchers identify mechanism of immune suppression in ovarian cancer

Weill Cornell Medicine researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack—blocking the energy supply T cells depend on. The study, published Oct. 23 in Nature, points toward a promising new immunotherapy approach for ovarian cancer, which is notoriously aggressive and hard to treat.

24 Oct 2024

3D-printed model created to mimic cancer metastasis

Scientists have created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells.

23 Oct 2024

Researchers create mini-brains to study autism and test new treatments

Using stem cells generated from patients with a rare and severe form of autism spectrum disorder and intellectual disability, Scripps Research scientists have grown personalized "mini-brains" (or organoids) to study the disorder in new detail.

23 Oct 2024

Human midbrain organoids: A promising tool in the fight against Parkinson's disease

Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.

23 Oct 2024

Axol Bioscience acquires Phenocell to advance human disease models

Axol Bioscience Ltd. (Axol), a leading induced pluripotent stem cell (iPSC) technology provider for drug discovery, today announced it has fully acquired Phenocell SAS, a pioneer in iPSC-based products and bioassays for skin and retinal disorders.

From Axol Bioscience Ltd 22 Oct 2024

Cancer cells use ribosomes to evade immune detection, study shows

The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system.

21 Oct 2024

Unraveling the mechanisms of B-cell maturation in blood cancer

Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according to the latest projections from the Spanish network of cancer registries (REDECAN).

21 Oct 2024

Kumamoto University makes groundbreaking discovery in aging and inflammation

A team at Kumamoto University has made a groundbreaking discovery in the field of aging and inflammation. Japan's aging population is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather than just lifespans.

20 Oct 2024

Transformative tissue engineering research in space

An "out-of-this-world" project has the potential to transform the future of tissue engineering and liver transplantation through innovative research conducted aboard the International Space Station (ISS).

18 Oct 2024

Ancient DNA reveals insights into starch digestion

If you've ever struggled to reduce your carb intake, ancient DNA might be to blame. It has long been known that humans carry multiple copies of a gene that allows us to begin breaking down complex carbohydrate starch in the mouth, providing the first step in metabolizing starchy foods like bread and pasta.

18 Oct 2024

Revolutionizing precision nutrition with gut microbiome insights

Researchers at Rutgers University-New Brunswick, along with international collaborators, have introduced a novel method for identifying the crucial set of gut microbes commonly found in humans and essential for health.

18 Oct 2024

Researchers develop strategies to identify regulators of intestinal hormone secretion

A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion.

18 Oct 2024

Researchers create first single cell atlas of prenatal human skin

For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.

18 Oct 2024

New protein found to protect cells from age-related decline

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

18 Oct 2024

Enhancing mRNA lifespan: A step forward in therapeutic development

mRNA-based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA.

16 Oct 2024

Two programs found to control invasion and inflammation in segregated tumor cell populations

Understanding in depth how tumors evolve to become malignant is the objective of the latest study led by the Cell Plasticity in Development and Disease laboratory, directed by ángela Nieto at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.

16 Oct 2024

Cellular Origins, Fresenius Kabi sign development agreement for scalable automation of cell and gene therapy manufacturing

Cellular Origins and Fresenius Kabi, an operating company of Fresenius, announce today they have signed a development agreement that leverages each company’s expertise in cell and gene therapies (CGTs).

16 Oct 2024

Transposons play essential role in early human development

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

16 Oct 2024