Cell Biology

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RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Cytochromes P450 enzymes exhibit unique soft-robotic properties, study reveals

Study reveals an important discovery in the realm of nanomachines within living systems.

8 Aug 2023

Nanoscale tattoos for tracking the health of individual cells

Engineers have developed nanoscale tattoos - dots and wires that adhere to live cells - in a breakthrough that puts researchers one step closer to tracking the health of individual cells.

8 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Deep learning improves protein design by 10x

The key to understanding proteins - such as those that govern cancer, COVID-19, and other diseases - is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

3 Aug 2023

Mothers' diet during pregnancy can protect brain health of children and grandchildren

Mothers who eat apples and herbs in early pregnancy could be protecting the brain health of their children and grandchildren, a Monash University study using genetic models has found.

3 Aug 2023

Nanoengineered bioink improves tumor model accuracy

Scientists from the Terasaki Institute for Biomedical Innovation have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinting of tumor models.

3 Aug 2023

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Researchers characterizes the structures and functions of potent bispecific antibodies against multiple Omicron subvariants using Cryo-EM.

3 Aug 2023

Innovative 3D cell culture platform could replace the use of animals in research

PeptiMatrix is the latest spin-out company from the University of Nottingham, providing access to an innovative 3D cell culture platform that aims to replace the use of animals in research.

3 Aug 2023

TU Graz researchers gain new insights into a light-activated protein switch

Researchers at TU Graz have gained new insights into the functioning of a protein found in bacteria, whose enzymatic activity is activated by blue light.

3 Aug 2023

Study offers deeper understanding of regulatory T cells yielding therapeutic benefits

Decades of research have left knowledge gaps about cells that regulate the immune system: Purdue and NIH.

1 Aug 2023

Study provides new insights into the intricate cellular processes driving heterotopic ossification

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation.

1 Aug 2023

AirGels: A game-changer for research on respiratory infections

Biofilms are highly resistant communities of bacteria that pose a major challenge in the treatment of infections.

1 Aug 2023

Study reveals internal structure of polyelectrolyte complexes for the first time

For years, we've known that a special kind of molecular assembly known as a "polyelectrolyte complex" helps your cells keep themselves organized.

31 Jul 2023

Novel tool uncovers new cell types in the visual system of flies

New York University researchers have discovered new cell types in the visual system of flies, made possible by their creation of a tool that finds and labels neurons during development.

31 Jul 2023

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Neurons are the cells that constitute neural circuits and use chemicals and electricity to receive and send messages that allow the body to do everything, including thinking, sensing, moving, and more.

28 Jul 2023

New method allows the discovery of specific inhibitors of lactate transporter

Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas.

28 Jul 2023

Study unravels how mitochondria call for help when under stress

Originally, the powerhouses of higher cells, the mitochondria, were independent organisms. Researchers at Goethe University Frankfurt have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response.

28 Jul 2023

Microbial cell factories produce eco-friendly food and cosmetic compounds

Despite decades of global population growth, global food crisis seems to be at hand yet again because the food productivity is cut severely due to prolonged presence of abnormal weather from intensifying climate change and global food supply chain is deteriorated due to international conflicts such as wars exacerbating food shortages and nutritional inequality around the globe.

28 Jul 2023

Cell Biology

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Cytochromes P450 enzymes exhibit unique soft-robotic properties, study reveals

Nanoscale tattoos for tracking the health of individual cells

Mitochondrial protein structure activates cell's integrated stress response

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Deep learning improves protein design by 10x

Mothers' diet during pregnancy can protect brain health of children and grandchildren

Nanoengineered bioink improves tumor model accuracy

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Innovative 3D cell culture platform could replace the use of animals in research

TU Graz researchers gain new insights into a light-activated protein switch

Study offers deeper understanding of regulatory T cells yielding therapeutic benefits

Study provides new insights into the intricate cellular processes driving heterotopic ossification

AirGels: A game-changer for research on respiratory infections

Study reveals internal structure of polyelectrolyte complexes for the first time

Novel tool uncovers new cell types in the visual system of flies

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

New method allows the discovery of specific inhibitors of lactate transporter

Study unravels how mitochondria call for help when under stress

Microbial cell factories produce eco-friendly food and cosmetic compounds

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