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PeptiDream develops novel macrocyclic peptide inhibitor for treatment of multiple influenza strains

PeptiDream Inc., a public Tokyo-based biopharmaceutical company ("PeptiDream")( TOKYO:4587) announced today, in collaboration with The Tokyo Metropolitan Institute of Medical Science ("Tokyo Metropolitan Institute") the discovery and development of a novel macrocyclic peptide inhibitor for the treatment of multiple influenza strains.

8 Apr 2014

Bristol-Myers Squibb submits NDAs to FDA for treatment of genotype 1b hepatitis C

Bristol-Myers Squibb Company (NYSE:BMY) announced today that they have submitted new drug applications (NDAs) with the U.S. Food and Drug Administration (FDA) for the investigational products daclatasvir (DCV), an NS5A replication complex inhibitor, and asunaprevir (ASV), a NS3 protease inhibitor.

8 Apr 2014

Antimicrobial agent in personal care products boosts colonization of bacteria inside human noses

An antimicrobial agent found in common household soaps, shampoos and toothpastes may be finding its way inside human noses where it promotes the colonization of Staphylococcus aureus bacteria and could predispose some people to infection.

8 Apr 2014

Research to understand exactly how bleach kills bacteria

Spring cleaning often involves chlorine bleach, which has been used as a disinfectant for hundreds of years. But our bodies have been using bleach's active component, hypochlorous acid, to help clean house for millennia. As part of our natural response to infection, certain types of immune cells produce hypochlorous acid to help kill invading microbes, including bacteria.

8 Apr 2014

Researchers show Elafin protein plays key role against inflammatory reaction typical of celiac disease

Scientists from INRA and INSERM (France) in collaboration with scientists from McMaster University (Canada) and the Ecole polytechnique fédérale of Zurich (Switzerland) have shown that Elafin, a human protein, plays a key role against the inflammatory reaction typical of celiac disease (gluten intolerance).

8 Apr 2014

Researchers warn that chikungunya virus is poised to invade in the Americas

A team of French and Brazilian researchers warn that chikungunya virus is poised to invade, and become epidemic in the Americas according to research published ahead of print in the Journal of Virology.

8 Apr 2014

Added benefit of antiviral drug combination in treatment of HIV-1 patients is not proven

The German Institute for Quality and Efficiency in Health Care (IQWiG) reassessed the antiviral drug combination rilpivirine/emtricitabine/tenofovir. In early 2012, the combination was approved for the treatment of adults infected with human immunodeficiency virus type 1 (HIV-1) who have not received previous antiretroviral treatment.

8 Apr 2014

Researchers show that vitamin B3 can slow down progression of mitochondrial disease

The researchers of the University of Helsinki, Finland, and école Polytechnique Fédérale de Lausanne, Switzerland, have shown that vitamin B3 form nicotinamide riboside can slow down the progression of mitochondrial disease, suggesting its potential as a novel therapy approach to adult-onset mitochondrial muscle diseases.

7 Apr 2014

Repellents from Greek herb extracts show potent effects against malaria carrying mosquitoes

Repellents derived from Greek herb extracts show potent effects, as spatial repellents, against malaria carrying mosquitoes, and possibly others.

4 Apr 2014

Researchers develop new eco repellent that stops mosquitoes from attacking humans

This year's World Health Day (April 7th) focuses on vector-borne diseases, like malaria. Malaria still kills more than half a million people every year, mainly children. In the battle against this disease researchers in Switzerland have developed a new eco repellent that stops mosquitoes from attacking humans.

4 Apr 2014

Janssen begins Phase 3 OPTIMIST trials for treatment of chronic Genotype 1 HCV infection

Janssen R&D Ireland (Janssen) announced today that two Phase 3 trials are recruiting patients to examine the efficacy and safety of the NS3/4A protease inhibitor simeprevir in combination with the nucleotide inhibitor sofosbuvir for the treatment of chronic genotype 1 hepatitis C virus (HCV) infection in treatment-naive and treatment-experienced patients with and without cirrhosis.

3 Apr 2014

Gilead reports topline results from sofosbuvir Phase 3 trial in Japan for treatment of HCV infection

Gilead Sciences, Inc. today announced topline results from a Phase 3 clinical trial (Study GS-US-334-0118) in Japan evaluating the once-daily nucleotide analog polymerase inhibitor sofosbuvir in combination with ribavirin (RBV) for the treatment of genotype 2 chronic hepatitis C virus (HCV) infection.

3 Apr 2014

Humans appear to develop immunity against strain-specific Lyme disease that lasts for years

Lyme disease, if not treated promptly with antibiotics, can become a lingering problem for those infected. But a new study led by researchers from the University of Pennsylvania has some brighter news: Once infected with a particular strain of the disease-causing bacteria, humans appear to develop immunity against that strain that can last six to nine years.

3 Apr 2014

FDA grants Fast Track designations for IV and oral formulations of Tetraphase's eravacycline

Tetraphase Pharmaceuticals, Inc. today announced that the U.S. Food & Drug Administration has granted Fast Track designations for both the intravenous (IV) and oral formulations of the company's lead antibiotic candidate, eravacycline.

3 Apr 2014

New cluster of viral meningitis cases found among Los Angeles area gay men

In response to reports of a new cluster of viral meningitis cases found among Los Angeles area gay men and men-who-have-sex-with-men (MSM), Los Angeles County Public Health Department officials are expected to release an official statement later today in which they will recommend that HIV-positive MSM and high-risk HIV-negative MSM be vaccinated against the infection.

3 Apr 2014

JPIAMR outlines steps to minimise antimicrobial resistance

Antibiotics have saved millions of lives from once deadly infectious diseases. But, misuse of antibiotics and other antimicrobials in humans and animals has led to bacteria evolving resistance.

3 Apr 2014

Research findings suggest new strategy in fight against HIV infection

New research suggests that drugs commonly used to prevent organ rejection after transplantation may also be helpful for combating HIV. The findings, which are published in the American Journal of Transplantation, suggest a new strategy in the fight against HIV and AIDS.

3 Apr 2014

Frail elderly people are at increased risk of death from outbreaks of viral gastroenteritis

Frail elderly people living in residential care facilities are at increased risk of severe illness or death from outbreaks of viral gastroenteritis.

3 Apr 2014

WHO to highlight increasing threat of vector-borne diseases on World Health Day 2014

More than half the world's population is at risk from diseases such as malaria, dengue, leishmaniasis, Lyme disease, schistosomiasis, and yellow fever, carried by mosquitoes, flies, ticks, water snails and other vectors. Every year, more than one billion people are infected and more than one million die from vector-borne diseases.

2 Apr 2014

FDA expands age indication of Adacel vaccine for immunization against tetanus, diphtheria, pertussis

Sanofi Pasteur, the vaccines division of Sanofi, announced today that the U.S. Food and Drug Administration (FDA) has expanded the approved age indication of Adacel® (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed; Tdap) for active booster immunization for the prevention of tetanus, diphtheria, and pertussis as a single dose in persons 10 through 64 years of age.

2 Apr 2014

Disease/Infection News

PeptiDream develops novel macrocyclic peptide inhibitor for treatment of multiple influenza strains

Bristol-Myers Squibb submits NDAs to FDA for treatment of genotype 1b hepatitis C

Antimicrobial agent in personal care products boosts colonization of bacteria inside human noses

Research to understand exactly how bleach kills bacteria

Researchers show Elafin protein plays key role against inflammatory reaction typical of celiac disease

Researchers warn that chikungunya virus is poised to invade in the Americas

Added benefit of antiviral drug combination in treatment of HIV-1 patients is not proven

Researchers show that vitamin B3 can slow down progression of mitochondrial disease

Repellents from Greek herb extracts show potent effects against malaria carrying mosquitoes

Researchers develop new eco repellent that stops mosquitoes from attacking humans

Janssen begins Phase 3 OPTIMIST trials for treatment of chronic Genotype 1 HCV infection

Gilead reports topline results from sofosbuvir Phase 3 trial in Japan for treatment of HCV infection

Humans appear to develop immunity against strain-specific Lyme disease that lasts for years

FDA grants Fast Track designations for IV and oral formulations of Tetraphase's eravacycline

New cluster of viral meningitis cases found among Los Angeles area gay men

JPIAMR outlines steps to minimise antimicrobial resistance

Research findings suggest new strategy in fight against HIV infection

Frail elderly people are at increased risk of death from outbreaks of viral gastroenteritis

WHO to highlight increasing threat of vector-borne diseases on World Health Day 2014

FDA expands age indication of Adacel vaccine for immunization against tetanus, diphtheria, pertussis

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