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Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a marker for severe HCV-induced graft inflammation, as well as a predictor for unsuccessful treatment.

3 Mar 2011

Seven-year study finds Group B strep as main cause of newborn bacterial meningitis

The Group B Streptococcus is still the most common cause of bacterial meningitis in newborns, concludes a seven-year French study in the March issue of The Pediatric Infectious Disease Journal.

3 Mar 2011

CDC report shows 58% decline in bloodstream infections in U.S. hospital ICUs

A report released yesterday by the U.S. Centers for Disease Control and Prevention shows that central line-associated bloodstream infections declined by 58 percent in U.S. hospital intensive care units.

3 Mar 2011

Study: Fluoride forms on teeth is up to 100 times thinner than previously believed

In a study that the authors describe as lending credence to the idiom, "by the skin of your teeth," scientists are reporting that the protective shield fluoride forms on teeth is up to 100 times thinner than previously believed.

2 Mar 2011

IAVI, THSTI collaborate to establish HIV Vaccine Design Program in India

The Translational Health Sciences and Technology Institute, an autonomous institute of the Indian government's Department of Biotechnology, and the International AIDS Vaccine Initiative announced today an agreement to jointly establish, operate and fund an HIV Vaccine Design Program in India.

2 Mar 2011

Calypte Biomedical completes new Aware HIV-1/2 oral fluid rapid test internal studies

Calypte Biomedical Corporation, a developer, manufacturer and marketer of HIV diagnostic tests, today announced successful completion of internal studies of its new Aware HIV-1/2 oral fluid rapid test for the US and international markets.

2 Mar 2011

FDA clears Meridian's illumigene C. difficile molecular amplification test

Meridian Bioscience, Inc., Cincinnati, Ohio today announced that it has received clearance from the U.S. Food and Drug Administration for a new pediatric claim for its illumigene C. difficile molecular amplification test. C. difficile is a bacterium that is frequently associated with antibiotic therapy often causing diarrhea and, in severe cases, a life-threatening inflammation of the colon.

2 Mar 2011

Novabay commences NVC-422 catheter Phase 2 trial to treat UCBE

NovaBay Pharmaceuticals, Inc., a clinical stage biotechnology company developing its first-in-class, anti-infective Aganocide compounds for the local non-systemic treatment and prevention of antibiotic-resistant infections, today provided an update on its Phase 2 clinical trial for the use of its lead compound, NVC-422, to prevent urinary catheter blockage and encrustation which is often a contributing factor to urinary tract infections in chronically catheterized patients.

2 Mar 2011

Virostatics' VS411 Phase 2a trial results against HIV presented at 18th CROI

An analysis of immune markers measured in a sub-study of ViroStatics' proof-of-concept Phase 2a trial showed that VS411 was able to reduce immune activation while producing a median 1.5 log10 reduction in viral load.

2 Mar 2011

New report finds 58% drop in CLABSIs in hospital intensive care units

A new report issued today by the Centers for Disease Control and Prevention showed a significant decrease in certain infections over the past nine years. The report found that central line associated bloodstream infections occurring in hospital intensive care units dropped by 58 percent between 2001 and 2009.

2 Mar 2011

Inter Press Service explores how Kenya's Anti-Counterfeit Act, possible EU-India free trade agreement could scale back access to affordable medications

Inter Press Service examines how legislation in Kenya targeting counterfeit medications and a possible EU-India Free Trade Agreement could scale back access to affordable and safe generic medications widely used in developing countries.

2 Mar 2011

Accelr8 to present new BACcel test study results against hVISA in Europe

Accelr8 Technology Corporation announced that one of its outside principal investigators received acceptance to present results of a new study in Europe.

2 Mar 2011

Court case question: Who holds the patent — drug company or research institution

The invention of an AIDS test is a big deal, and it takes a lot of time, smarts and money to develop a good one. So there's a lot at stake in the legal tussle between Stanford University and the pharmaceutical giant Roche, with oral arguments opening Monday before the U.S. Supreme Court.

2 Mar 2011

Baxter announces European rMRP approval of PREFLUCEL seasonal influenza vaccine

Baxter International Inc. announced today the approval of a European repeat mutual recognition procedure (rMRP) by the Austrian Agency for Health and Food Safety for Baxter's PREFLUCEL seasonal influenza vaccine. The 13 participating European Union countries, including Germany, Spain, United Kingdom and Nordic countries, will formally implement the license on a national level to make PREFLUCEL available for the 2011-12 influenza season.

From Baxter International Inc. 2 Mar 2011

Scientists at retrovirus conference present findings on microbicide gel, Truvada, male circumcision, ART care by nurses

At the annual Conference on Retroviruses and Opportunistic Infections (CROI) in Boston on Monday, researchers "suggested the potential" of a gel containing the antiretroviral drug tenofovir to reduce the risk of anal HIV transmission, TIME's "Healthland" blog reports.

2 Mar 2011

New insight into HIV/AIDS

A paper published in the March 2011 print edition of the Journal of Clinical Investigation offers new insight into what prompts immunity to AIDS in sooty mangabeys, a natural host African monkey species.

2 Mar 2011

Vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus

An AIDS vaccine tested in people, but found to be ineffective, influenced the genetic makeup of the virus that slipped past. The findings suggest new ideas for developing HIV vaccines.

2 Mar 2011

EPO to grant patent for Apricus MycoVa product to treat nail fungus

Apricus Biosciences, Inc. announced today that the European Patent Office will grant a patent for the company's MycoVa product for treating onychomycosis.

2 Mar 2011

Existing plans for drug use during flu pandemic can reduce wastewater treatment efficiency

Existing plans for antiviral and antibiotic use during a severe influenza pandemic could reduce wastewater treatment efficiency prior to discharge into receiving rivers, resulting in water quality deterioration at drinking water abstraction points.

2 Mar 2011

OneWorld Health receives FDA clearance for iOWH032 phase 1 trials to treat secretory diarrhea

The Institute for OneWorld Health (iOWH) announced a major milestone in the fight against cholera. The Food and Drug Administration (FDA) granted iOWH permission to begin phase 1 trials for iOWH032, a drug to treat secretory diarrhea. This is the first submission of an Investigational New Drug application for a completely new chemical entity by a non-profit of this size to receive such rapid FDA clearance, and it could be the first synthetic drug of its kind for diarrheal diseases.

2 Mar 2011

Disease/Infection News

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

Seven-year study finds Group B strep as main cause of newborn bacterial meningitis

CDC report shows 58% decline in bloodstream infections in U.S. hospital ICUs

Study: Fluoride forms on teeth is up to 100 times thinner than previously believed

IAVI, THSTI collaborate to establish HIV Vaccine Design Program in India

Calypte Biomedical completes new Aware HIV-1/2 oral fluid rapid test internal studies

FDA clears Meridian's illumigene C. difficile molecular amplification test

Novabay commences NVC-422 catheter Phase 2 trial to treat UCBE

Virostatics' VS411 Phase 2a trial results against HIV presented at 18th CROI

New report finds 58% drop in CLABSIs in hospital intensive care units

Inter Press Service explores how Kenya's Anti-Counterfeit Act, possible EU-India free trade agreement could scale back access to affordable medications

Accelr8 to present new BACcel test study results against hVISA in Europe

Court case question: Who holds the patent — drug company or research institution

Baxter announces European rMRP approval of PREFLUCEL seasonal influenza vaccine

Scientists at retrovirus conference present findings on microbicide gel, Truvada, male circumcision, ART care by nurses

New insight into HIV/AIDS

Vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus

EPO to grant patent for Apricus MycoVa product to treat nail fungus

Existing plans for drug use during flu pandemic can reduce wastewater treatment efficiency

OneWorld Health receives FDA clearance for iOWH032 phase 1 trials to treat secretory diarrhea

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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