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mRNA therapy shows promise for maple syrup urine disease

Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease (MSUD).

22 Aug 2024

Cautious optimism in San Francisco as new cases of HIV In Latinos decrease

For years, Latinos represented the biggest share of new HIV cases in this city, but testing data suggests the tide may be turning.

21 Aug 2024

Breakthrough treatment reduces liver fibrosis in Hepatitis C patients

HCV infection is the underlying cause for chronic Hepatitis C (CHC), liver cirrhosis, and liver cancer or hepatocellular carcinoma (HCC). In 2019, over 2,90,000 people died of HCV-related diseases. Recent medical advancement made a new breakthrough treatment available for patients with hepatitis C. DAAs that block replication of HCV has dramatically transformed the treatment approach with around 90% effective anti-viral response rates. However, it is unclear whether DAAs impact the severity of disease burden caused by liver fibrosis.

21 Aug 2024

Spatial transcriptomics unlocks malaria's liver stage secrets

For the malaria parasite to reach the blood of its human host, it must first enter the liver, where only a small number of parasites differentiate and replicate for upwards of seven days, making it a bottleneck in the parasite's lifecycle. This bottleneck makes the liver stage an optimal target for effective and long-lasting vaccines against the disease. Using Spatial Transcriptomics and single-cell RNA-sequencing technologies, researchers at Stockholm University have for the first time managed to create a spatio-temporal map of malaria infection in the mouse liver. A study that was recently published in Nature Communications.

21 Aug 2024

UC Davis researchers unveil pathway for Salmonella's gut invasion

How do bad bacteria find entry points in the body to cause infection? This question is fundamental for infectious disease experts and people who study bacteria.

20 Aug 2024

New genomic technique tracks superbugs in hospitals for faster infection management

Researchers have developed a new genomic technique that can track the spread of multiple superbugs in a hospital simultaneously, which could help prevent and manage common hospital infections quicker and more effectively than ever before.

20 Aug 2024

First meeting of the International Health Regulations Emergency Committee reports on mpox surge

The Director-General of the World Health Organization (WHO), having concurred with the advice offered by the International Health Regulations (2005) (IHR or Regulations) Emergency Committee regarding the upsurge of mpox 2024 during its first meeting, held on 14 August 2024, has determined, on the same date, that the ongoing upsurge of mpox in the Democratic Republic of the Congo (DRC) and in a growing number of countries in Africa constitutes a public health emergency of international concern (PHEIC) under the provisions of the Regulations.

20 Aug 2024

Global and Local Efforts to Take Action Against Hepatitis

In this interview, we explore global and local efforts to combat viral hepatitis with Lindsey Hiebert, Deputy Director of the Coalition for Global Hepatitis Elimination (CGHE), and James Amugsi, a Mandela Washington Fellow and Physician Assistant at Sandema Hospital in Ghana. Together, they provide valuable insights into the challenges, successes, and the importance of partnerships in the fight against hepatitis.

20 Aug 2024

Psychosocial stressors at work increase workers' risk of atrial fibrillation, study suggests

Researchers evaluated the individual and combined effects of workplace psychosocial stressors, such as effort-reward imbalance and job strain, on atrial fibrillation incidence.

20 Aug 2024

Study reveals time-of-day impact on cerebral malaria severity

A discovery by McGill-affiliated researchers could lead to more effective treatment of malaria and other parasitic diseases.

19 Aug 2024

Study reveals how avian flu adapts to mammalian cells

In recent years, public health measures, surveillance, and vaccination have helped bring about significant progress in reducing the impact of seasonal flu epidemics, caused by human influenza viruses A and B.

19 Aug 2024

State COVID-19 vaccine mandates increased vaccine uptake among healthcare workers in 2021

Researchers investigated the relationship between state COVID-19 vaccination mandates for healthcare workers and vaccination rates among them.

19 Aug 2024

Colorado's $100 copay cap improves diabetes medication adherence and health outcomes

Researchers examined the relationship between Colorado's $100 copayment maximum and self-expenditure, medication compliance, and health service usage for diabetes-associated comorbidities.

19 Aug 2024

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

The long-term subjective cognitive decline risk associated with Herpes zoster infections.

19 Aug 2024

Calls for humanitarian pause to safeguard polio vaccination efforts in Gaza

Two rounds of a polio vaccination campaign are expected to be launched at the end of August and September 2024 across the Gaza Strip to prevent the spread of circulating variant type 2 poliovirus (cVDPV2).

18 Aug 2024

New insights into COVID-19 spike protein offer hope for universal vaccines

A team led by Jose Onuchic at Rice University and Paul Whitford at Northeastern University, both researchers at the National Science Foundation Physics Frontiers Center at the Center for Theoretical Biological Physics (CTBP) at Rice, has made a discovery in the fight against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19.

16 Aug 2024

Researchers develop four new regimens to treat people with multidrug-resistant TB meningitis

In a preliminary study with a small number of humans, rabbits and mice, researchers at Johns Hopkins Children's Center say they have developed four new regimens that have the potential to treat and save the lives of people with multidrug-resistant (MDR) tuberculous (TB) meningitis.

16 Aug 2024

Tecovirimat shows no significant impact on mpox lesion duration in DRC study

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Disease/Infection News

mRNA therapy shows promise for maple syrup urine disease

Cautious optimism in San Francisco as new cases of HIV In Latinos decrease

Breakthrough treatment reduces liver fibrosis in Hepatitis C patients

Spatial transcriptomics unlocks malaria's liver stage secrets

UC Davis researchers unveil pathway for Salmonella's gut invasion

New genomic technique tracks superbugs in hospitals for faster infection management

First meeting of the International Health Regulations Emergency Committee reports on mpox surge

Global and Local Efforts to Take Action Against Hepatitis

Psychosocial stressors at work increase workers' risk of atrial fibrillation, study suggests

Study reveals time-of-day impact on cerebral malaria severity

Study reveals how avian flu adapts to mammalian cells

State COVID-19 vaccine mandates increased vaccine uptake among healthcare workers in 2021

Colorado's $100 copay cap improves diabetes medication adherence and health outcomes

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

Calls for humanitarian pause to safeguard polio vaccination efforts in Gaza

New insights into COVID-19 spike protein offer hope for universal vaccines

Researchers develop four new regimens to treat people with multidrug-resistant TB meningitis

Tecovirimat shows no significant impact on mpox lesion duration in DRC study

Texas A&M leads effort to combat cattle fever ticks

Scientists discover how hospital superbug rapidly evolves resistance to frontline treatment

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