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Mice study shows how to improve long-term effectiveness of TB vaccine

Briefly blocking a key molecule when administering the only approved vaccine for tuberculosis vastly improves long-term protection against the devastating disease in mice, researchers from Texas Biomedical Research Institute report this week in the Journal of Immunology.

11 Mar 2022

Canadian scientist discusses about how society could better prepare for future pandemics

Aled Edwards is of two minds about medicine's response to COVID-19. On one hand, he notes, we had life-saving vaccines and therapies less than a year after the discovery of SARS-CoV-2. On the other, more than six million, and possibly as many as 18 million people have died, and global access to advances that can prevent and treat severe disease remains highly inequitable.

11 Mar 2022

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

A recent systematic review and meta-analysis evaluated the safety and efficacy of intensified anticoagulation therapy in COVID-19 patients.

11 Mar 2022

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

A recent study assessed the safety and immunogenicity of mRNA-1273 booster vaccine against COVID-19.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Researchers assessed the increase in Pfizer/BioNTech BNT162b2 vaccine efficacy on administering a homologous booster dose.

11 Mar 2022

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Researchers evaluated the immune responses after boosting with Pfizer's BNT162b2 vaccine.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Researchers elucidated antiviral activities of aminoglycoside geneticin against seven SARS-CoV-2 variants using different cell lines and respiratory tissues.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers defined a novel polynucleotide-based Distinctiveness metric to capture the proteome-level differences of emerging SARS-CoV-2 variants and lineages against all previously identified ones.

11 Mar 2022

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

Cancer patients who have compromised immune systems due to their disease or therapy remain at high risk for COVID-19 infection.

10 Mar 2022

New study analyzes COVID-19 outcomes in patients with cancer

If a cancer patient tests positive for COVID-19, are they more likely to become hospitalized from the disease?

10 Mar 2022

Study shows vaccine effectiveness against SARS-CoV-2 and severe disease in dialysis patients

Multiple studies have shown that individuals with kidney failure who are undergoing dialysis mount weaker antibody responses after COVID-19 vaccination than people in the general population, but new research indicates that these individuals' immune responses are still capable of protecting against SARS-CoV-2 infection and severe COVID-19.

10 Mar 2022

Three vaccine doses are crucial to achieve effective protection against omicron

mRNA vaccines are highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants. But three doses are needed to achieve a similar level of protection against omicron that two doses provide against the delta and alpha variants, finds a large US study published by The BMJ today.

10 Mar 2022

KHN’s ‘What the Health?’: Congress shelves covid funding for now

Congress is moving toward completion of its annual spending bills for the fiscal year that started last October, but a last-minute snag jettisoned from the bill the Biden administration's requested funding for covid prevention and treatment.

10 Mar 2022

Long-lasting immune activity in the airways may be the cause of persistent post-COVID-19 breathlessness

Long-lasting immune activity in the airways might be the cause of persistent breathlessness following COVID-19.

10 Mar 2022

Disease/Infection News

Mice study shows how to improve long-term effectiveness of TB vaccine

Canadian scientist discusses about how society could better prepare for future pandemics

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

Novel genetic relationships with severe SARS-CoV-2

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

New study analyzes COVID-19 outcomes in patients with cancer

Study shows vaccine effectiveness against SARS-CoV-2 and severe disease in dialysis patients

Three vaccine doses are crucial to achieve effective protection against omicron

KHN’s ‘What the Health?’: Congress shelves covid funding for now

Long-lasting immune activity in the airways may be the cause of persistent post-COVID-19 breathlessness

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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