Drug Discovery & Pharmaceuticals

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Moffitt scientists develop breakthrough method for scalable synthesis of withanolides

Withanolides, a class of naturally occurring compounds found in plants, have long been a focus of cancer research due to their ability to inhibit cancer cell growth, induce cell death and prevent metastasis.

28 Jun 2024

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Partners to host joint conference on ‘Protein Sciences in Drug Discovery’ in Cambridge, UK from 18–19 November 2024.

From ELRIG (UK) Ltd. 26 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides like strychnine and anticancer drugs such as vinblastine and minovincine.

24 Jun 2024

Transforming drug discovery with AI

A new AI-powered program will allow researchers to level up their drug discovery efforts.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Using deep learning to design synthetic soluble versions of cell membrane proteins

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

21 Jun 2024

Artificial variants of Withanolides act highly specifically against leukemia cells

Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells.

21 Jun 2024

Novel AI tool poised to reshape virtual screening in early stage drug discovery

Australian researchers, led by Monash University, have invented a new artificial intelligence (AI) tool which is poised to reshape virtual screening in early stage drug discovery and enhance scientists’ ability to identify potential new medicines.

19 Jun 2024

CCDC leverages computing power of Intel and AWS for advancement in drug discovery

Thanks to the combined computing power of Amazon Web Services (AWS) and Intel, the CCDC announces that a potentially significant advancement in drug discovery has been achieved.

18 Jun 2024

Release of Unity 2.0: Order, track, and manage your compound collection through one platform

eMolecules has launched a new updated platform that enables medicinal chemists or compound managers to order, track, and manage their compound collection and commercial sources through a more intuitive and flexible system: Unity.

From eMolecules 13 Jun 2024

From Discovery Biology to ELRIG Chair: A Conversation with Melanie Leveridge

In this interview, we speak with Melanie Leveridge, Vice President of Discovery Biology at AstraZeneca and Chair of the Board for ELRIG UK, to discuss her extensive career in the pharmaceutical industry, her role in fostering scientific innovation, and her vision for ELRIG's future.

From ELRIG (UK) Ltd. 13 Jun 2024

Deep learning revives ancient peptides to battle antibiotic resistance

Researchers used deep learning to resurrect antibiotic peptides from extinct organisms, offering new solutions for combating antibiotic resistance.

12 Jun 2024

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Drug Discovery & Pharmaceuticals

Moffitt scientists develop breakthrough method for scalable synthesis of withanolides

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

New enzyme targets hold promise for cancer therapies

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Transforming drug discovery with AI

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Using deep learning to design synthetic soluble versions of cell membrane proteins

Artificial variants of Withanolides act highly specifically against leukemia cells

Novel AI tool poised to reshape virtual screening in early stage drug discovery

CCDC leverages computing power of Intel and AWS for advancement in drug discovery

Release of Unity 2.0: Order, track, and manage your compound collection through one platform

From Discovery Biology to ELRIG Chair: A Conversation with Melanie Leveridge

Deep learning revives ancient peptides to battle antibiotic resistance

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

Transforming antibody drug discovery with Epitope Binning-seq

Molecular Devices opens custom-built site in Cardiff for manufacturing of patient-derived organoids

Simple peptide modification could unlock a whole class of targets for drug discovery

Artificial intelligence accelerates natural-product antibiotic discovery

New strategy targets rare B cells for effective HIV vaccine development

New vessel-chip deployment platform holds promise for personalized drug testing

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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