Drug Discovery & Pharmaceuticals

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Intratumoral bacteria linked with natural purple photosynthetic bacteria show strong anticancer efficacy

Cancer remains one of the leading causes of death worldwide. Researchers are constantly looking for new therapies with improved anticancer activity, fewer side effects, and lower costs.

8 May 2023

First CRISPR-armed phage therapeutic can specifically target and remove E. coli in the human gut

SNIPR Biome ApS ("SNIPR"), the company pioneering CRISPR-based microbial gene therapy, announces today that Nature Biotechnology has published research findings from its preclinical work on SNIPR001, the first CRISPR-armed phage therapeutic developed to specifically target and remove E. coli, including antibiotic-resistant strains, in the human gastrointestinal tract.

8 May 2023

The safety and efficacy of FINLAY-FR-2/1A, a new protein-based COVID-19 vaccine

Research paper reports the results of a phase 3 clinical trial evaluating the efficacy and safety of the FINLAY-FR-2 and FINLAY-FR-1A vaccines in Iranian adults.

7 May 2023

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

Research paper proposes a new method for predicting highly expressed genes based on codon usage bias and minimum free energy of mRNA secondary structures. The method involves constructing a stochastic grammar that generates sequences with high CAI and low MFE, and testing it on two mRNA vaccines.

3 May 2023

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

African psychedelic plant medicine inspires new drug candidates for treating addiction and depression

Scientists have developed two new drug candidates for potentially treating addiction and depression, modeled on the pharmacology of a traditional African psychedelic plant medicine called ibogaine.

2 May 2023

Paving the Way for New Drugs through Particle Perfection

Do particles hold the power to pave the way for new drugs? In this interview, we speak to Ben Knappett, head of science and applications at Particle Works to find out more!

From Society for Laboratory Automation and Screening (SLAS) 2 May 2023

Scientists identify broad-spectrum antiviral agents that can target multiple RNA virus families

A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.

28 Apr 2023

Revolutionizing drug discovery: Giga-scale screening unleashes power of AI and virtual libraries

Research discusses recent advances in computer-aided drug discovery, including the use of virtual screening and deep learning methods and their potential to revolutionize the drug discovery process by identifying diverse, potent, and drug-like ligands to protein targets.

28 Apr 2023

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

27 Apr 2023

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Insomnia drug shows potential as an effective treatment for opioid use disorder

The insomnia drug suvorexant (Belsomra) might be an effective treatment for opioid use disorder, according to a preclinical study from Scripps Research.

27 Apr 2023

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.

26 Apr 2023

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

To highlight how far the field of genetics has come, we spoke with Dr. Francis Collins, the leader of the Human Genome Project about his incredible career in genetics.

25 Apr 2023

Bioengineered drug candidate can counter S. aureus infection in early tests

Researchers at NYU Grossman School of Medicine and Janssen Biotech, Inc. have shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus – a bacterial species widely resistant to antibiotics and a major cause of death in hospitalized patients.

24 Apr 2023

Drug Discovery & Pharmaceuticals

Intratumoral bacteria linked with natural purple photosynthetic bacteria show strong anticancer efficacy

First CRISPR-armed phage therapeutic can specifically target and remove E. coli in the human gut

The safety and efficacy of FINLAY-FR-2/1A, a new protein-based COVID-19 vaccine

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

African psychedelic plant medicine inspires new drug candidates for treating addiction and depression

Paving the Way for New Drugs through Particle Perfection

Scientists identify broad-spectrum antiviral agents that can target multiple RNA virus families

Revolutionizing drug discovery: Giga-scale screening unleashes power of AI and virtual libraries

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Insomnia drug shows potential as an effective treatment for opioid use disorder

Groundbreaking discovery could pave the way for safer and more effective blood thinners

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

Bioengineered drug candidate can counter S. aureus infection in early tests

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

Study should spur the development of alternative range of anti-TB inhibitors

New drug could effectively disarm multidrug-resistant bacteria

New DCFHP-alum COVID-19 vaccine candidate shows durable, broad-spectrum protection in non-human primates

New biologic inactivates potent opioid and reverses overdose

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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