Drug Discovery & Pharmaceuticals

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New study lays foundation to obtain apple cubes enriched with probiotics

Researchers of the Universitat Politècnica de València and the Universidade Federal do Ceará (Brazil) have completed a study that lays the foundation to obtain apple cubes enriched with probiotics, namely Lactobacillus casei. The work has been published in the most recent edition of the Journal of Functional Foods.

27 Feb 2018

Artificial intelligence methods used for developing precision cancer medicine

A patient's own molecular data can be used to identify, with the use of artificial intelligence methods, the best combinatorial multi-drug therapy for that patient. Network modelling plays a major role in this line of work.

27 Feb 2018

Research reveals anti-cancer effects of natural extract from Daffodils

A research describes the anti-cancer effects of a natural alkaloid extracted from Daffodils. Led by Denis Lafontaine, affiliated with the Faculty of Sciences at the ULB, the researchers have discovered that this compound triggers the activation of an anti-tumoral surveillance pathway.

26 Feb 2018

Researchers develop first analytical method to evaluate new cyanide and mustard gas antidote

To develop antidotes for chemical agents, such as cyanide and mustard gas, scientists need analytical methods that track not only the level of exposure but also how the drug counteracts the effects of the chemical.

24 Feb 2018

Desymmetrization paves way for new bioactive compounds

Many chemical molecules can exist in nature together with their mirror counterparts; like hands, two compounds can be made up of the same atoms in the same overall structure but in opposite orientations, i.e. left-handed and right-handed.

23 Feb 2018

Reformulating vaccines to prevent relapse

Substance abuse, particularly opioid abuse, is an ongoing issue in the U.S. While treatments such as drug counseling and a handful of medications to combat withdrawal symptoms and cravings exist, the fear and risk of relapsing is real.

21 Feb 2018

Antibiotic-producing bacterium releases more metabolites than assumed

The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment.

21 Feb 2018

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

AbbVie, a global biopharmaceutical company, and Voyager Therapeutics, Inc., a clinical-stage gene therapy company, today announced that they have entered into an exclusive strategic collaboration and option agreement to develop and commercialize vectorized antibodies directed against tau for the treatment of Alzheimer's disease and other neurodegenerative diseases.

20 Feb 2018

'Click chemistry' approach may improve disease-fighting properties of drugs

Researchers at The Scripps Research Institute have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties.

19 Feb 2018

Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency

About 70 percent of pharmaceuticals are manufactured using palladium-driven catalytic processes that are either fast or efficient - but not both.

14 Feb 2018

Professor Jean-Charles Soria granted award for pioneering role in cancer drug development

The TAT 2018 Honorary Award for cancer drug development has been granted to Professor Jean-Charles Soria, for his pioneering role in cancer drug development across molecular targeted agents, precision medicine, and immunotherapy.

12 Feb 2018

Researchers create new device to accelerate, improve accuracy of drug screening process

McMaster University engineers have devised a way to make testing for new drugs more efficient and affordable, and reduce the time for helpful medications to reach the public.

9 Feb 2018

Researchers develop safe, potent mRNA vaccine adjuvants that can elicit effective immune response

Production of conventional vaccines, which involves the use of live-attenuated or purified protein subunits of pathogens, is a long and complex process. Nucleic acid vaccines are safer alternatives, and allow easy adjustment of antigen to target specific pathogens.

9 Feb 2018

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

A group of Brazilian scientists achieved promising results using isolated compounds from the venom of the South American rattlesnake in combat of hepatitis C.

8 Feb 2018

Researchers test effectiveness of investigational drug in treating diastolic dysfunction of the heart

Researchers at the University of Colorado School of Medicine have identified a potential treatment target for patients with a common type of heart failure.

8 Feb 2018

First drug-candidate compounds discovered using AI licensed for development

Insilico Medicine, Inc., a Baltimore-based next-generation artificial intelligence company specializing in the application of deep learning for drug discovery, announces that Juvenescence.AI, its joint venture with Juvenescence Limited, has licensed its first compound family for clinical development.

7 Feb 2018

IU scientists take important step to fight against hepatitis B with 'virus-cracking' molecules

Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer.

7 Feb 2018

Previously discarded antibiotic compounds could become life-saving drugs

Researchers are re-examining antibacterial compounds to see whether they could hold the key to fighting drug-resistant infections.

7 Feb 2018

UIC scientists identify new chemical compound to stop bacteria from causing sickness

A study published in the Journal of Biological Chemistry is the first to describe a signaling pathway that affects communication -- a process called quorum sensing -- between Streptococcus bacteria cells.

6 Feb 2018

Open Pharma drug discovery project aims to develop new treatments for mycetoma

The MycetOS project was launched today by the University of Sydney, Erasmus MC, and the Drugs for Neglected Diseases initiative to use an Open Pharma approach to discover compounds that could lead to new treatments for patients suffering from fungal mycetoma (eumycetoma), a devastating disease for which current treatments are ineffective, expensive, and toxic.

6 Feb 2018

Drug Discovery & Pharmaceuticals

New study lays foundation to obtain apple cubes enriched with probiotics

Artificial intelligence methods used for developing precision cancer medicine

Research reveals anti-cancer effects of natural extract from Daffodils

Researchers develop first analytical method to evaluate new cyanide and mustard gas antidote

Desymmetrization paves way for new bioactive compounds

Reformulating vaccines to prevent relapse

Antibiotic-producing bacterium releases more metabolites than assumed

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

'Click chemistry' approach may improve disease-fighting properties of drugs

Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency

Professor Jean-Charles Soria granted award for pioneering role in cancer drug development

Researchers create new device to accelerate, improve accuracy of drug screening process

Researchers develop safe, potent mRNA vaccine adjuvants that can elicit effective immune response

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

Researchers test effectiveness of investigational drug in treating diastolic dysfunction of the heart

First drug-candidate compounds discovered using AI licensed for development

IU scientists take important step to fight against hepatitis B with 'virus-cracking' molecules

Previously discarded antibiotic compounds could become life-saving drugs

UIC scientists identify new chemical compound to stop bacteria from causing sickness

Open Pharma drug discovery project aims to develop new treatments for mycetoma

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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