Drug Discovery & Pharmaceuticals

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Detailed phenotypic information on resistance genes can guide future drug development

The genes that are able to equip bacteria with resistance to clinically used antibiotics have been found in many different natural environments. Nevertheless, a functional overview of the resistance genes found in common human bacterial pathogens has been missing so far.

6 Feb 2018

Researchers report technical advances in production of HIV vaccines

Research on HIV over the past decade has led to many promising ideas for vaccines to prevent infection by the AIDS virus, but very few candidate vaccines have been tested in clinical trials.

6 Feb 2018

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.

2 Feb 2018

Scientists synthesize new multifunctional compound that has anti-tumor properties

A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects.

2 Feb 2018

Scientists develop immune-stimulating injections against cancer

A team of researchers have developed two immune-stimulating injections, that removed all traces of cancer when injected directly into solid mouse tumors.

2 Feb 2018

Scientists discover the genetic cause of immune disorders

Scientists from the Cincinnati Children’s have successfully identified a gene mutation that affects T cell function and promotes immune disorders.

1 Feb 2018

Study paves new way for development of vaccines against epidemics

The search for vaccines, treatments and preventive methods against infection by emerging viruses is one of the major challenges of global epidemiology.

30 Jan 2018

Researchers propose novel solution to minimize recurrent caries

When patients go to the dentist to fill a cavity, they're trying to solve a problem -- not create a new one. But many dental patients get some bad news: bacteria can dig under their tooth-colored fillings and cause new cavities, called recurrent caries.

30 Jan 2018

Researchers discover new source of botulinum neurotoxin

A new source of the botulinum neurotoxin was discovered by Canadian and American scientists in a strain of animal gut bacteria known as Enterococcus faecium.

27 Jan 2018

UTokyo enters into agreement for developing personalized cancer vaccine

The University of Tokyo entered an agreement for developing a personalized cancer vaccine using a novel method involving the body's immune response.

25 Jan 2018

UK-based charity to accelerate development of promising new drug for Parkinson's

UK-based charity, Parkinson's UK is set to provide more than $1million in funding to US biotech company, Neurolixis, to accelerate the development of a promising new drug for people with Parkinson's.

24 Jan 2018

Toothpaste ingredient could be employed as anti-malarial drug against drug-resistant parasites

An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one of the currently-used drugs.

19 Jan 2018

Potential male birth control pill could be developed from arrow poison

Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none.

18 Jan 2018

Researchers identify new anti-inflammatory drug target

A new study suggests that parmodulins may provide anti-inflammatory and anti-thrombotic protection to endothelial cells, without interfering with clotting.

16 Jan 2018

Researchers discover new type of botulinum neurotoxin from unexpected source

Researchers from the Quadram Institute have identified genes encoding a previously undiscovered version of the botulinum neurotoxin in bacteria from a cow's gut.

12 Jan 2018

New drug candidates may offer breakthrough in treatment of COPD

The study was a cooperative effort between the team headed by assistant professor Dr Jürgen Knobloch from the Medical Clinic III for Pneumology, Sleep and Respiratory Medicine at the Bergmannsheil University Hospital in Bochum, Germany, and Prof Dr Andrea Koch, member of the German Center for Lung Research, previously in Bochum, now at the Medical Clinic V for Pneumology at the LMU University Hospital in Munich, as well as a team from the company RespiVert Ltd, a subsidiary of Janssen Biotech Inc., and Prof Dr Erich Stoelben from the Lung Clinic in Köln-Merheim.

12 Jan 2018