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Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

Researchers from the University of Washington (UW), Kenya Medical Research Institute (KEMRI), and Hennepin Healthcare Research Institute (HHRI) announced results at CROI from a clinical trial demonstrating that doxycycline taken after sex does not prevent bacterial sexually transmitted infections (STIs) – chlamydia or gonorrhea – among cisgender women.

20 Feb 2023

Lord James O'Shaughnessy appointed to conduct an independent review into UK clinical trials

The government has appointed Lord James O'Shaughnessy, Senior Partner at consultancy firm Newmarket Strategy, Board Member of Health Data Research UK (HDR UK), and former Health Minister, to conduct an independent review into the UK commercial clinical trials landscape.

20 Feb 2023

Are SGLT2 inhibitors the next blockbuster drug?

Recent clinical trials investigating the therapeutic potency of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have highlighted that this drug is highly effective in treating patients with cardiovascular and renal diseases.

19 Feb 2023

A new trial to assess if butyrate can prevent colon cancer

Researchers discuss a new clinical trial that will determine the efficacy of butyrate administration in preventing colon cancer.

16 Feb 2023

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Researchers examine non-hospitalized adult patients with COVID-19 treated with nirmatrelvir-ritonavir.

15 Feb 2023

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

Patients with resectable non-small cell lung cancer (NSCLC) who were treated with neoadjuvant nivolumab had improved five-year recurrence-free and overall survival rates compared with historical outcomes.

15 Feb 2023

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

The National Institutes of Health has initiated a multi-site clinical trial evaluating an investigational antiviral for the treatment of COVID-19.

15 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

A study of two widely used cardiovascular medications — cilostazol and isosorbide mononitrate — in more than 350 patients confirmed the two medications were well-tolerated and safe for people who have experienced a stroke in a small blood vessel deep in the brain.

13 Feb 2023

Pegylated interferon lambda shows good efficacy against COVID-19

In a recent study published in The New England Journal of Medicine, researchers used the TOGETHER platform trial protocol to perform a phase III randomized controlled trial (RCT) to evaluate the effectiveness of pegylated interferon (IFN) lambda (λ) therapy in outpatients with coronavirus disease 2019 (COVID-19) in Canada and Brazil.

9 Feb 2023

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Researchers describe a novel SARS-CoV-2 spike protein component vaccine called MT-001.

9 Feb 2023

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Stand Up To Cancer today announced four teams focused on increasing diversity in early phase cancer clinical trials.

8 Feb 2023

Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

8 Feb 2023

Men with low sexual desire might benefit from kisspeptin

A new study in the journal JAMA Network Open aimed to analyze the mechanistic and clinical effects of the administration of kisspeptin in men with HSDD.

7 Feb 2023

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

NRG Oncology Phase III clinical trial, NRG-GY018, evaluating pembrolizumab in combination with standard of care chemotherapy (carboplatin and paclitaxel) met its primary endpoint of progression free survival (PFS) for the treatment of patients with stage III-IV or recurrent endometrial carcinoma, regardless of mismatch repair status.

3 Feb 2023

Pitavastatin plus ezetimibe can help decrease blood lipid levels in patients with coronary heart disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. According to the findings of randomized controlled trials, blood lipid levels in patients with coronary heart disease (CHD) can be significantly decreased through a combination of pitavastatin and ezetimibe; however, the effects and clinical applications of this treatment remain controversial.

2 Feb 2023

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

People who had an ischemic (clot-caused) stroke and were treated with a clot-busting medication and/or mechanical clot removal and also received butylphthalide, a medication initially compounded from celery seed, experienced milder neurological symptoms with better functioning at three months after the stroke, compared to stroke patients who had their clots treated but received a placebo medication, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2023.

2 Feb 2023

Mays Cancer Center leads a study evaluating Phase I and Phase III clinical trials for breast cancer drug

The Mays Cancer Center, home to UT Health San Antonio MD Anderson Cancer Center, was the lead site for a study evaluating Phase I and Phase III clinical trials for elacestrant, a treatment for postmenopausal women and adult men with ER+/HER2- advanced or metastatic breast cancer.

1 Feb 2023

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times in patients with triple-negative breast cancer (TNBC) that has a "BRCA-like" phenotype.

31 Jan 2023

Experimental vaccine against Marburg virus shows promise in first-in-human clinical trial

A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial.

30 Jan 2023

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Drug Trial News

Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

Lord James O'Shaughnessy appointed to conduct an independent review into UK clinical trials

Are SGLT2 inhibitors the next blockbuster drug?

A new trial to assess if butyrate can prevent colon cancer

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

Neuroprotectant linked to reduced death and disability among stroke patients

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

Pegylated interferon lambda shows good efficacy against COVID-19

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Men with low sexual desire might benefit from kisspeptin

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

Pitavastatin plus ezetimibe can help decrease blood lipid levels in patients with coronary heart disease

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

Mays Cancer Center leads a study evaluating Phase I and Phase III clinical trials for breast cancer drug

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Experimental vaccine against Marburg virus shows promise in first-in-human clinical trial

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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