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Patients with myelofibrosis show improvement in disease-related symptoms when treated with momelotinib

Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 Jan 2023

"The Trust Circle": Inclusion of indigenous patients in clinical trials

Indigenous populations, including people of American Indian and Alaska Native origin, are underrepresented in clinical trials.

23 Jan 2023

CHLA launches first clinical trial for Down syndrome regression disorder with $5.3 million NIH grant

Children's Hospital Los Angeles has launched the first clinical trial for Down syndrome regression disorder (DSRD), a rare and debilitating condition that affects adolescents and young adults with Down syndrome.

23 Jan 2023

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

In a recent study published in The Lancet Microbe journal, researchers described the effectiveness of a modular capsid virus-like coronavirus disease 2019 (COVID-19) vaccination.

22 Jan 2023

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

A four-drug chemotherapy regimen provided longer overall survival than a two-drug combination in a Phase 3 clinical trial for metastatic pancreatic ductal adenocarcinoma.

20 Jan 2023

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Adding nab-paclitaxel to a standard treatment of gemcitabine plus cisplatin does not significantly extend median overall survival (OS) time for patients with advanced biliary tract cancers, although it may provide a benefit for subsets of patients with locally advanced disease or gallbladder adenocarcinoma.

20 Jan 2023

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined.

18 Jan 2023

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

A promising approach to control Staphylococcus aureus bacterial colonization in people-;using a probiotic instead of antibiotics-;was safe and highly effective in a Phase 2 clinical trial.

17 Jan 2023

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics that promote remyelination for the treatment of neurological diseases such as multiple sclerosis, announced today it has entered into an exclusive worldwide license agreement with UCB.

12 Jan 2023

Study evaluates the efficacy of complementary use of corticosteroid treatment for community-acquired pneumonia

Announcing a new publication for Acta Materia Medica journal. The objective of this study was to systematically evaluate the clinical efficacy of the complementary use of corticosteroids in the treatment of community-acquired pneumonia (CAP).

11 Jan 2023

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

Posoleucel, an investigational allogeneic off-the-shelf T-cell therapy that simultaneously targets six different viruses, demonstrated promising antiviral efficacy and safety in a phase II study of patients who had undergone stem cell transplantation to treat their cancer or other blood diseases.

11 Jan 2023

Novel T cell receptor therapy shows early promise for treating solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

9 Jan 2023

Study shows the potential of a game-changing drug to treat upper urinary tract urothelial cancers

A team from 15 U.S. medical centers led by UT Southwestern Simmons Cancer Center researchers has performed the first analysis of a potentially game-changing drug to treat upper urinary tract urothelial cancers.

4 Jan 2023

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

A three-dose regimen of a whole-parasite vaccine against malaria – called Plasmodium falciparum sporozoite (PfSPZ) vaccine – demonstrated safety and efficacy when tested in adults living in Burkina Faso, West Africa, which has endemic malaria.

4 Jan 2023

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

A clinical trial led by the National Cancer Institute (NCI), part of the National Institutes of Health, has resulted in the first approval of a treatment for advanced alveolar soft part sarcoma (ASPS).

28 Dec 2022

Molnupiravir does not reduce hospitalization or deaths in vaccinated adults with COVID-19, but improves recovery

Molnupiravir (taken as an 800mg dose twice daily for five days) does not reduce hospital admissions or deaths in vaccinated adults with COVID-19 infection who are at higher risk of mortality, according to the results of a randomised controlled trial, published in The Lancet journal.

23 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

21 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

Clinical trials demonstrate safety and efficacy of Ebola Zaire vaccines

Two vaccines against the Zaire strain of Ebola virus are immunogenic and safe in both adults and children, according to initial results from two phase II clinical trials published in the New England Journal of Medicine.

21 Dec 2022

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Drug Trial News

Patients with myelofibrosis show improvement in disease-related symptoms when treated with momelotinib

"The Trust Circle": Inclusion of indigenous patients in clinical trials

CHLA launches first clinical trial for Down syndrome regression disorder with $5.3 million NIH grant

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

Study evaluates the efficacy of complementary use of corticosteroid treatment for community-acquired pneumonia

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

Novel T cell receptor therapy shows early promise for treating solid tumors

Study shows the potential of a game-changing drug to treat upper urinary tract urothelial cancers

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

Molnupiravir does not reduce hospitalization or deaths in vaccinated adults with COVID-19, but improves recovery

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

Clinical trials demonstrate safety and efficacy of Ebola Zaire vaccines

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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