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Study offers hope for a new therapeutic option for patients with severe asthma

A new monoclonal antibody therapy shows promise in offering an alternative treatment for patients suffering from moderate-to-severe asthma. Research led by Michael E. Wechsler, MD, MMSc, director of the National Jewish Health Cohen Family Asthma Institute, found that itepekimab was safe and effective in a phase 2 trial published online today in the New England Journal of Medicine.

28 Oct 2021

Using fluvoxamine to treat COVID-19 patients reduces the need for prolonged hospitalization, trial shows

The results of a new randomized clinical trial, published in The Lancet Global Health, have demonstrated that using fluvoxamine to treat high-risk outpatients with early-diagnosed COVID-19 reduced the need for prolonged observation in an emergency setting or hospitalization, compared to a control group who received a placebo.

28 Oct 2021

Promising new therapy for mesothelioma to enter a Phase I clinical trial

Linked to occupational asbestos exposure, malignant mesothelioma (MM) is an aggressive cancer arising primarily from the outer lining of the lungs with a dismal five-year survival rate of only five to 10 percent.

27 Oct 2021

Clinical trial shows no benefit of tamoxifen in treating deadly fungal meningitis

Hopes that tamoxifen could improve survival for a deadly form of fungal meningitis have been dashed by clinical trial results published in eLife.

26 Oct 2021

Can targeting autophagy become a new approach to COVID-19 treatment?

In a recent review, the author discusses autophagy as a contributing mechanism of selected drugs that are currently being evaluated to treat COVID‐19.

25 Oct 2021

Study examines effectiveness of BNT162b2 vaccine against Delta variant in adolescents

The Clalit Research Institute, in collaboration with researchers from Harvard University, analyzed one of the world's largest integrated health record databases to examine the effectiveness of the Pfizer/BioNTech BNT162B2 vaccine against the Delta variant of SARS-CoV-2 among adolescents.

22 Oct 2021

Investigational inhaled COVID-19 treatment graduates to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group, the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that the external data and safety monitoring board (DSMB) has recommended that SNG001, an inhaled formulation of interferon beta, advance to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

21 Oct 2021

New shorter treatment regimen found to be safer, more effective at treating drug-resistant TB

A new all-oral six-month treatment regimen is safer and more effective at treating rifampicin-resistant tuberculosis (RR-TB) than the current accepted standard of care, according to results announced at the 52nd Union World Conference on Lung Health.

20 Oct 2021

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia.

18 Oct 2021

Phase 2 study shows safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine

The results of a phase 2 clinical trial featuring a SARS-CoV-2 recombinant protein vaccine developed by GlaxoSmithKline are reported, demonstrating a favorable immune response amongst both naïve and non-naïve adults with an acceptable safety profile.

15 Oct 2021

High-dose CIMT produces longer lasting improvements in children with hemiparetic cerebral palsy

Children with hemiparetic cerebral palsy, a movement disorder that affects use of one side of the body, showed improved use of the arm and hand after receiving a high dose of Constraint-Induced Movement Therapy (CIMT) in a clinical trial funded by the National Institutes of Health.

14 Oct 2021

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

A new study introduces the possibility that the inactivated polio vaccine can elicit antibodies that inhibit SARS-CoV-2 nucleic acid synthesis.

10 Oct 2021

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

The results of Phase I clinical trials for two new COVID-19 vaccine candidates based on recombinant RDB proteins are reported.

10 Oct 2021

COVID-19 vaccine clinical trial for children is underway in St. Louis

A pediatric COVID-19 vaccine clinical trial is underway in St. Louis. Led by Washington University School of Medicine, about 140 area children will receive the two-shot Moderna vaccine or placebo at St. Louis Children's Hospital as part of a clinical trial involving about 100 medical institutions in the U.S. and Canada.

6 Oct 2021

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

A new study reports on the results of phase III clinical trial on the safety and efficacy of the AstraZeneca-Oxford COVID-19 vaccine.

5 Oct 2021

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

In the earliest days of the COVID-19 pandemic, the medical community turned to a century-old treatment: Take blood from recovered patients and give it to the sick.

4 Oct 2021

J&J vaccine prevents SARS-CoV-2-induced thrombosis and inflammation in hamsters

In a recent study, researchers performed bulk RNA-Seq transcriptomic profiling of lungs from vaccinated and unvaccinated hamsters with the Janssen vaccine.

4 Oct 2021

Researchers launch new study of COVID-19 vaccination schedules in 12-to-16-year-olds

Researchers running the University of Oxford-led Com-COV programme have launched a new study of COVID-19 vaccination schedules in young people aged 12 to 16.

4 Oct 2021

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

The phase 1-2 clinical trials conducted using REGEN-COV had shown promising therapeutic benefits in COVID-19 outpatients. Its effect was further investigated in the present phase 3 clinical trial, the findings of which have been published in the "The New England Journal of Medicine".

3 Oct 2021

Researchers publish new datasets to better train machine learning models for drug discovery

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions.

2 Oct 2021

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Drug Trial News

Study offers hope for a new therapeutic option for patients with severe asthma

Using fluvoxamine to treat COVID-19 patients reduces the need for prolonged hospitalization, trial shows

Promising new therapy for mesothelioma to enter a Phase I clinical trial

Clinical trial shows no benefit of tamoxifen in treating deadly fungal meningitis

Can targeting autophagy become a new approach to COVID-19 treatment?

Study examines effectiveness of BNT162b2 vaccine against Delta variant in adolescents

Investigational inhaled COVID-19 treatment graduates to phase 3 in ACTIV-2 trial

New shorter treatment regimen found to be safer, more effective at treating drug-resistant TB

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

Phase 2 study shows safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine

High-dose CIMT produces longer lasting improvements in children with hemiparetic cerebral palsy

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

COVID-19 vaccine clinical trial for children is underway in St. Louis

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

J&J vaccine prevents SARS-CoV-2-induced thrombosis and inflammation in hamsters

Researchers launch new study of COVID-19 vaccination schedules in 12-to-16-year-olds

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

Researchers publish new datasets to better train machine learning models for drug discovery

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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