Histology & Microscopy

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Breakthrough in understanding influenza's protective coat opens path to new treatments

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, made up of eight RNA molecules.

17 Dec 2024

DTI detects precancerous lesions in the pancreas

Precursor lesions of pancreatic cancer are very difficult to characterize with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreiro – respectively head of the Preclinical MRI lab at Champalimaud Research and a doctor at the Champalimaud Clinical Centre's Radiology Department – have shown, for the first time, that a particular form of MRI, called Diffusion Tensor Imaging (DTI), is capable of robustly detecting pre-malignant lesions in the pancreas.

13 Dec 2024

Reimagining axons with the pearls-on-a-string model

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

6 Dec 2024

New study sheds light on the molecular basis of gene expression

An international research collaboration has shed new light on the molecular basis of gene expression, the fundamental biological process that underpins how all organisms use their genetic information.

2 Dec 2024

Spatial transcriptomics uncovers new treatment paths for triple-negative breast cancer

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative breast cancer (TNBC). The findings identify nine spatial archetypes and gene signatures linked to immunotherapy response and patient outcomes.

2 Dec 2024

Bacteria modify their ribosomes in response to the antibiotics

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published today in Nature Communications. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.

29 Nov 2024

Advanced microscopy reveals how ribosomes attach to mRNA for protein synthesis

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA.

28 Nov 2024

Nanoscale cellular interactions unveiled by the SoTILT3D imaging platform

A team of researchers led by Anna-Karin Gustavsson at Rice University has developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale.

27 Nov 2024

The role of emotion regulation in predicting suicidal risk in depressed individuals

Depressed individuals who reflexively attempt to dampen their initial emotional responses to reminders of their negative memories have a low tolerance for distressing emotional stimuli in general and may respond to stress in their daily lives with greater upticks in suicidal thoughts.

26 Nov 2024

CrestOptics and Tomocube partner to advance 3D imaging with new multimodal imaging platform

CrestOptics S.p.A., a manufacturer of high-end microscopy solutions and advanced systems for fluorescence microscopy, and Tomocube, a leader in holotomography (HT) technology, today announced a strategic collaboration to provide a next-generation multimodal imaging platform, the HT-X1™ Plus

From CrestOptics 25 Nov 2024

Advanced 3D brain models created to study memory and perception

The hippocampus is one of the most fascinating brain regions. Associated with the formation of memories, it also helps us to navigate through the world without getting lost.

22 Nov 2024

Parkinson's disease drug disrupts the gut microbiome by inducing iron deficiency

In a groundbreaking new study, conducted within the framework of the FWF-funded Cluster of Excellence "Microbiomes drive Planetary Health", scientists from the University of Vienna, in collaboration with the University of Southampton, Aalborg University and Boston University, have revealed that the widely prescribed Parkinson's disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.

22 Nov 2024

New microscopy technique enables 3D RNA analysis in intact mouse brains

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains.

22 Nov 2024

Malaria crystal structure offers clues for more effective medications

Prof. Leslie Leiserowitz first became intrigued by malaria when he was a young boy in South Africa. His father, who scouted the continent in search of wood for the family business, brought back not only tales of elephants and gorillas but also skin rashes and ringing in his ears, side effects of the quinine he took to prevent malaria.

19 Nov 2024

TB pathogen's surprising growth mechanism challenges bacterial biology

The rod-shaped tuberculosis (TB) bacterium, which the World Health Organization has once again ranked as the top infectious disease killer globally, is the first single-celled organism ever observed to maintain a consistent growth rate throughout its life cycle.

15 Nov 2024