Histology & Microscopy

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New insights into how the Sudan virus attaches to human cells

The Sudan virus, a close relative of Ebola, has a fatality rate of 50% but remains poorly understood in terms of how it infects cells. Currently, no approved treatments exist.

4 Feb 2025

New microscopy technique offers affordable way to study cancer cell metabolism

Understanding how tumors change their metabolism to resist treatments is a growing focus in cancer research.

3 Feb 2025

New microscopy technique uncovers 'ribosome cooperativity' in difficult situations

Researchers from the Tanenbaum group at the Hubrecht Institute have developed a new microscopy technique to observe how ribosomes function in cells.

31 Jan 2025

Study reveals how glial cells respond to damage in neuron dendrites

Neurons may get all the glory, but they would be nothing without glial cells. While brain cells do the heavy lifting in the nervous system, it's the glia that provide nutrients, clean up waste, and protect neurons from harm.

29 Jan 2025

High-speed in-line force mapping unveils E. coli cell division dynamics

Light and electron microscopy have distinct limitations. Light microscopy makes it difficult to resolve smaller and smaller features, and electron microscopy resolves small structures, but samples must be meticulously prepared, killing any live specimens.

29 Jan 2025

BEND lipids revolutionize mRNA delivery and gene-editing

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station.

28 Jan 2025

Study reveals impact of fava bean proteins on sensory cells in the mouth

Researchers at the Leibniz Institute for Food Systems Biology at the Technical University of Munich have for the first time investigated how protein structures derived from fava beans affect a cellular model of human oral tactile cells.

25 Jan 2025

MIT breakthrough enables fast and uniform protein labeling in 3D tissues

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.

24 Jan 2025

Breakthrough discovery sheds light on how brain cells activate learning genes

A breakthrough study published today in the Journal of Neuroscience sheds new light on how brain cells relay critical information from their extremities to their nucleus, leading to the activation of genes essential for learning and memory.

21 Jan 2025

Biglycan and decorin play crucial roles in bone health

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin.

10 Jan 2025

Breakthrough microscopy technique reveals how antibodies target cancer cells

In blood cancers such as chronic lymphocytic leukaemia, B cells of the immune system multiply uncontrollably.

10 Jan 2025

Innovative AI approach enhances imaging in thick biological samples

Depth degradation is a problem biologists know all too well: The deeper you look into a sample, the fuzzier the image becomes.

7 Jan 2025

Oldest evidence of evolutionary arms race found in fossils

A new study led by researchers at the American Museum of Natural History presents the oldest known example in the fossil record of an evolutionary arms race.

3 Jan 2025

Advancing Raman microscopy for high-resolution imaging of biological samples

Understanding the behavior of the molecules and cells that make up our bodies is critical for the advancement of medicine.

30 Dec 2024

The "Goldilocks" zone: A key to cellular adaptability and resilience

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists at Scripps Research have unlocked the secret interactions between a primordial inorganic polymer of phosphate known as polyphosphate (polyP), and two basic building blocks of life: DNA and the element magnesium.

24 Dec 2024

Breakthrough in understanding influenza's protective coat opens path to new treatments

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, made up of eight RNA molecules.

17 Dec 2024

DTI detects precancerous lesions in the pancreas

Precursor lesions of pancreatic cancer are very difficult to characterize with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreiro – respectively head of the Preclinical MRI lab at Champalimaud Research and a doctor at the Champalimaud Clinical Centre's Radiology Department – have shown, for the first time, that a particular form of MRI, called Diffusion Tensor Imaging (DTI), is capable of robustly detecting pre-malignant lesions in the pancreas.

13 Dec 2024

Reimagining axons with the pearls-on-a-string model

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

6 Dec 2024

New study sheds light on the molecular basis of gene expression

An international research collaboration has shed new light on the molecular basis of gene expression, the fundamental biological process that underpins how all organisms use their genetic information.

2 Dec 2024

Spatial transcriptomics uncovers new treatment paths for triple-negative breast cancer

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative breast cancer (TNBC). The findings identify nine spatial archetypes and gene signatures linked to immunotherapy response and patient outcomes.

2 Dec 2024