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Quercetin and resveratrol may play an important role in inflammation and insulin resistance

A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene and protein markers of inflammation and insulin resistance were measured.

24 Dec 2010

Molecular-level insights into how physical activity influences the heart

Everyone knows that exercise comes with metabolic and cardiovascular benefits, but scientists understand surprisingly little about how physical activity influences the heart itself. Now, a new study in the December 23rd issue of Cell, a Cell Press publication, offers some of the first molecular-level insights.

24 Dec 2010

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

By tweaking a single gene, scientists have mimicked in sedentary mice the heart-strengthening effects of two weeks of endurance training, according to a report from Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center (BIDMC).

24 Dec 2010

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

The cell signaling pathway known as Wnt, commonly activated in cancers, causes internal membranes within a healthy cell to imprison an enzyme that is vital in degrading proteins, preventing the enzyme from doing its job and affecting the stability of many proteins within the cell, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

24 Dec 2010

Silencing of specific genes of germinal cell lines reduces brain tumors

Scientists at IRB Barcelona have discovered that some brain tumours in larvae of the fruit fly Drosophila melanogaster use the genetic programme of germline cells to grow. The removal of some of these genes leads to healthy brains. This finding demonstrates that these genes are crucial for tumour development. The study, headed by ICREA researcher Cayetano Gonz-lez, is published today in the prestigious journal Science.

24 Dec 2010

Teva receives FDA complete response letter for glatiramer acetate 0.5mL injection sNDA

Teva Pharmaceutical Industries Ltd. announced today that it has received a complete response letter from the U.S. Food and Drug Administration (FDA) for its supplemental New Drug Application (sNDA) for a lower-volume (0.5mL) injection of glatiramer acetate. Copaxone® containing 20mg of glatiramer acetate in 1ml is the global market leader in the treatment of relapsing-remitting multiple sclerosis (RRMS).

24 Dec 2010

Alimera receives FDA CRL for ILUVIEN NDA

pSivida Corp., a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, including the investigational drug ILUVIEN® for the treatment of Diabetic Macular Edema (DME), today announced that Alimera Sciences, Inc, pSivida's collaborative partner, received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) regarding its New Drug Application (NDA) for ILUVIEN. The FDA issued the CRL to communicate its decision that the NDA cannot be approved in its present form.

24 Dec 2010

Researchers study relationship between MITF, ATF2 in melanoma development

Melanoma is one of the least common types of skin cancer, but it is also the most deadly. Melanocytes (pigment-producing skin cells) lose the genetic regulatory mechanisms that normally limit their number, allowing them to divide and proliferate out of control. One such regulator, called MITF, controls an array of genes that influence melanocyte development, function and survival.

24 Dec 2010

Study shows vegetarian diet lowers blood, urine phosphorous levels

Phosphorous levels plummet in kidney disease patients who stick to a vegetarian diet, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology. The results suggest that eating vegetables rather than meat can help kidney disease patients avoid accumulating toxic levels of this mineral in their bodies.

24 Dec 2010

Oxytocin makes individuals feel calmer and dampens effect on fear receptor in the brain

"My husband of thirty-five years passed away seven years ago, and I lost my daughter in a car accident last year, I honestly could no longer find the energy to smile or laugh," recounts sixty-year-old widow Opal Perry. "My son suggested I try a new hormone being touted to help with symptoms of depression, called oxytocin. After the second day I was driving and caught myself smiling in the mirror. I couldn't believe it. I had to do a double take. I hadn't really smiled in seven years! I thought I would never smile again until now."

23 Dec 2010

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Spectrum Pharmaceuticals, a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, announced today that the target enrollment has been reached for the Phase 2 study of belinostat in Carcinoma of Unknown Primary (CUP).

23 Dec 2010

Power, anthropomorphism, and risk perception

People who feel powerful are more likely to believe they can beat cancer if it's described in human terms, according to new study in the Journal of Consumer Research.

23 Dec 2010

Preoperative cerebral oxygen saturation could be a risk marker for adverse cardiac surgery outcome

A study published in the January 2011 issue of Anesthesiology is one of the first to show that low preoperative cerebral oxygen saturation (ScO2) could be an important physiological risk marker for adverse outcome in cardiac surgery patients.

23 Dec 2010

MCP-1 protein may contribute to failure of AV fistulas created for vascular access in dialysis patients

A protein implicated in the development of vascular diseases may also contribute to the failure of arteriovenous (AV) fistulas created for vascular access in dialysis patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

23 Dec 2010

Renal Advantage, Liberty Dialysis announce deal closure

Renal Advantage and Liberty Dialysis, which last month agreed to combine to form the third largest provider of dialysis services in the U.S., today announced that they have closed their deal. The transaction – terms of which were not disclosed – was completed on December 17, 2010. The combined organization has 5,300 employees serving more than 19,000 patients in 260 locations in 32 states.

23 Dec 2010

2010 'a watershed year' for lung cancer

Today, Lung Cancer Alliance (LCA) called 2010 "a watershed year" for lung cancer that included increased research funding, additional Congressional support, a new national coalition of key policy organizations, and the validation of CT screening - a convergence of forces that can reverse the historic underfunding and neglect of lung cancer.

23 Dec 2010

People eating fried fish in stroke belt states more likely to die of stroke: Study

Eating a Southern staple, fried fish, could be one reason people in Alabama and across the "stroke belt" states are more likely than other Americans to die of a stroke, according to a study published in the December 22, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology.

23 Dec 2010

EMCTO 2011 to provide update on treatment of thoracic malignancies

The number of diagnostic and therapeutic options for patients with thoracic malignancies has markedly increased, allowing for an individualized approach based on the clinical situation and molecular characteristics of the tumor. How to best select among these options for the benefit of the patients within an integrative treatment approach will be at the core of the conference.

23 Dec 2010

$Herbal pain medication gets fractured runner back running again$

Herbal pain medication gets fractured runner back running again

Debilitating injuries can impact quality of life long after the injury has occurred and healed, producing long-term pain and limited mobility. Individuals recuperating from a surgery or other procedure may want explore different options to getting back on their feet after an injury.

23 Dec 2010

Fraunhofer MEVIS initiates research partnership with ARTORG Center

In a research partnership between the Fraunhofer Institute for Medical Image Computing MEVIS in Bremen and the ARTORG Center for Biomedical Engineering Research at the University of Bern, this navigation technique will be intensively evaluated and developed further at the Eastern Hepatobiliary Surgery Hospital in Shanghai.

23 Dec 2010

Medical Condition News

Quercetin and resveratrol may play an important role in inflammation and insulin resistance

Molecular-level insights into how physical activity influences the heart

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

Silencing of specific genes of germinal cell lines reduces brain tumors

Teva receives FDA complete response letter for glatiramer acetate 0.5mL injection sNDA

Alimera receives FDA CRL for ILUVIEN NDA

Researchers study relationship between MITF, ATF2 in melanoma development

Study shows vegetarian diet lowers blood, urine phosphorous levels

Oxytocin makes individuals feel calmer and dampens effect on fear receptor in the brain

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Power, anthropomorphism, and risk perception

Preoperative cerebral oxygen saturation could be a risk marker for adverse cardiac surgery outcome

MCP-1 protein may contribute to failure of AV fistulas created for vascular access in dialysis patients

Renal Advantage, Liberty Dialysis announce deal closure

2010 'a watershed year' for lung cancer

People eating fried fish in stroke belt states more likely to die of stroke: Study

EMCTO 2011 to provide update on treatment of thoracic malignancies

Herbal pain medication gets fractured runner back running again

Fraunhofer MEVIS initiates research partnership with ARTORG Center

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

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