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New study shows striking changes, variations by region in admission rates for substance abuse treatment

Although the overall rate of admissions to substance abuse treatment in the U.S. remained stable between 1998 and 2008, at about 770 admissions for every 100,000 persons in the population, a new study shows striking changes and variations in admission rates by region. For example, the rate of admissions for alcohol as the primary drug has declined by 15 percent nationally. However admission rates for alcohol in West North Central states (Ark., Iowa, Kan., Minn., Mo., N.D., Neb. and S.D.) remained the same.

24 Dec 2010

Gold-coated liposomes could make chemotherapy more effective without harmful side effects

University of Arizona researchers may have found a way to deliver chemotherapeutic drugs to cancer tissues in controlled doses without harming healthy body cells.

24 Dec 2010

New derivation of stem cells from fat cells hold promise for therapeutic, cosmetic benefits

Two studies appearing in the current issue of Cell Transplantation 19(10) discuss stem cells derived from adipose (fat) cells and their potential use in plastic surgery and tissue reconstruction. The studies are now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

24 Dec 2010

AMPK activates autophagy by activating ATG1 enzyme

Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular recycling program to free up essential molecular building blocks in times of need.

24 Dec 2010

60% of type 2 diabetics who use insulin would switch to a less expensive biosimilar insulin if available

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that 60 percent of surveyed type 2 diabetes patients in the U.S. who currently use insulin indicate they would request that their doctor switch them to a less expensive biosimilar insulin if such an agent became available.

24 Dec 2010

Good Clostridia prevents development of allergies and inflammatory bowel disease

Scientists at the University of Tokyo have discovered that specific gut-dwelling bacteria control key immune cells that combat allergies and autoimmune diseases. The paper describing these findings was published in today's issue of the journal Science, and technology originating from the work is being advanced by start-up Vedanta Biosciences.

24 Dec 2010

Quercetin and resveratrol may play an important role in inflammation and insulin resistance

A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene and protein markers of inflammation and insulin resistance were measured.

24 Dec 2010

Molecular-level insights into how physical activity influences the heart

Everyone knows that exercise comes with metabolic and cardiovascular benefits, but scientists understand surprisingly little about how physical activity influences the heart itself. Now, a new study in the December 23rd issue of Cell, a Cell Press publication, offers some of the first molecular-level insights.

24 Dec 2010

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

By tweaking a single gene, scientists have mimicked in sedentary mice the heart-strengthening effects of two weeks of endurance training, according to a report from Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center (BIDMC).

24 Dec 2010

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

The cell signaling pathway known as Wnt, commonly activated in cancers, causes internal membranes within a healthy cell to imprison an enzyme that is vital in degrading proteins, preventing the enzyme from doing its job and affecting the stability of many proteins within the cell, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

24 Dec 2010

Silencing of specific genes of germinal cell lines reduces brain tumors

Scientists at IRB Barcelona have discovered that some brain tumours in larvae of the fruit fly Drosophila melanogaster use the genetic programme of germline cells to grow. The removal of some of these genes leads to healthy brains. This finding demonstrates that these genes are crucial for tumour development. The study, headed by ICREA researcher Cayetano Gonz-lez, is published today in the prestigious journal Science.

24 Dec 2010

Teva receives FDA complete response letter for glatiramer acetate 0.5mL injection sNDA

Teva Pharmaceutical Industries Ltd. announced today that it has received a complete response letter from the U.S. Food and Drug Administration (FDA) for its supplemental New Drug Application (sNDA) for a lower-volume (0.5mL) injection of glatiramer acetate. Copaxone® containing 20mg of glatiramer acetate in 1ml is the global market leader in the treatment of relapsing-remitting multiple sclerosis (RRMS).

24 Dec 2010

Alimera receives FDA CRL for ILUVIEN NDA

pSivida Corp., a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, including the investigational drug ILUVIEN® for the treatment of Diabetic Macular Edema (DME), today announced that Alimera Sciences, Inc, pSivida's collaborative partner, received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) regarding its New Drug Application (NDA) for ILUVIEN. The FDA issued the CRL to communicate its decision that the NDA cannot be approved in its present form.

24 Dec 2010

Researchers study relationship between MITF, ATF2 in melanoma development

Melanoma is one of the least common types of skin cancer, but it is also the most deadly. Melanocytes (pigment-producing skin cells) lose the genetic regulatory mechanisms that normally limit their number, allowing them to divide and proliferate out of control. One such regulator, called MITF, controls an array of genes that influence melanocyte development, function and survival.

24 Dec 2010

Study shows vegetarian diet lowers blood, urine phosphorous levels

Phosphorous levels plummet in kidney disease patients who stick to a vegetarian diet, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology. The results suggest that eating vegetables rather than meat can help kidney disease patients avoid accumulating toxic levels of this mineral in their bodies.

24 Dec 2010

Oxytocin makes individuals feel calmer and dampens effect on fear receptor in the brain

"My husband of thirty-five years passed away seven years ago, and I lost my daughter in a car accident last year, I honestly could no longer find the energy to smile or laugh," recounts sixty-year-old widow Opal Perry. "My son suggested I try a new hormone being touted to help with symptoms of depression, called oxytocin. After the second day I was driving and caught myself smiling in the mirror. I couldn't believe it. I had to do a double take. I hadn't really smiled in seven years! I thought I would never smile again until now."

23 Dec 2010

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Spectrum Pharmaceuticals, a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, announced today that the target enrollment has been reached for the Phase 2 study of belinostat in Carcinoma of Unknown Primary (CUP).

23 Dec 2010

Power, anthropomorphism, and risk perception

People who feel powerful are more likely to believe they can beat cancer if it's described in human terms, according to new study in the Journal of Consumer Research.

23 Dec 2010

Preoperative cerebral oxygen saturation could be a risk marker for adverse cardiac surgery outcome

A study published in the January 2011 issue of Anesthesiology is one of the first to show that low preoperative cerebral oxygen saturation (ScO2) could be an important physiological risk marker for adverse outcome in cardiac surgery patients.

23 Dec 2010

MCP-1 protein may contribute to failure of AV fistulas created for vascular access in dialysis patients

A protein implicated in the development of vascular diseases may also contribute to the failure of arteriovenous (AV) fistulas created for vascular access in dialysis patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

23 Dec 2010

Medical Condition News

New study shows striking changes, variations by region in admission rates for substance abuse treatment

Gold-coated liposomes could make chemotherapy more effective without harmful side effects

New derivation of stem cells from fat cells hold promise for therapeutic, cosmetic benefits

AMPK activates autophagy by activating ATG1 enzyme

60% of type 2 diabetics who use insulin would switch to a less expensive biosimilar insulin if available

Good Clostridia prevents development of allergies and inflammatory bowel disease

Quercetin and resveratrol may play an important role in inflammation and insulin resistance

Molecular-level insights into how physical activity influences the heart

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

Silencing of specific genes of germinal cell lines reduces brain tumors

Teva receives FDA complete response letter for glatiramer acetate 0.5mL injection sNDA

Alimera receives FDA CRL for ILUVIEN NDA

Researchers study relationship between MITF, ATF2 in melanoma development

Study shows vegetarian diet lowers blood, urine phosphorous levels

Oxytocin makes individuals feel calmer and dampens effect on fear receptor in the brain

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Power, anthropomorphism, and risk perception

Preoperative cerebral oxygen saturation could be a risk marker for adverse cardiac surgery outcome

MCP-1 protein may contribute to failure of AV fistulas created for vascular access in dialysis patients

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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