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Two Phase I studies of Stedivaze demonstrate safety in patients with asthma and COPD

Clinical Data, Inc., today announced results from two Phase I studies of Stedivaze™ (apadenoson), which demonstrated that Stedivaze was safe and well tolerated in patients with asthma and chronic obstructive pulmonary disease (COPD). Stedivaze is a potent and highly selective agonist of the adenosine A2A receptor subtype in development as a pharmacologic stress agent for myocardial perfusion imaging (MPI).

30 Mar 2010

Savient Pharmaceuticals' resubmission of BLA for KRYSTEXXA accepted for FDA review

Savient Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration has acknowledged receipt of and accepted for review the March 15, 2010 resubmission of the Biologics License Application for KRYSTEXXA™ (pegloticase), a treatment for chronic gout in patients refractory to conventional therapy.

30 Mar 2010

Neuroscientists prevent memory loss in fruit flies by blocking activity of PI3 kinase signaling protein

By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer's disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, which was previously thought to have a protective function against the disease.

30 Mar 2010

Genetically manipulating rats to emulate Alzheimer's disease in humans

Prof. Claudio Cuello at McGill University and his collaborators have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments. Alzheimer's is a devastating brain condition leading to a progressive decline of memory and other brain functions. Although research mice have been developed in the past, rats are more intelligent than other rodents and the behavior of these rats is rich and predictable, which means that for the first time researchers will be able to detect and study the evolution of learning and memory deficits.

30 Mar 2010

Campbell Soup honored for commitment to food allergy safety, awareness and education

Campbell Soup Company was recently honored by the Food Allergy and Anaphylaxis Network for its commitment to food allergy safety, awareness and education.

30 Mar 2010

Mood altering effects of Phenytoin

Phenytoin is a well known antiepileptic agent widely used throughout the world. Recent clinical studies in patients with bipolar disorder have suggested that, as for other anticonvulsant drugs commonly used in the treatment of bipolar patients including valproate and carbamazepine, phenytoin may have mood-stabilizing effects in addition to its well-known anticonvulsant properties.

30 Mar 2010

Wellness Formulations introduces Dermal Renu Sunshield

Wellness Formulations, LLC, a leader in anti-glycation research and product development, has launched Dermal Renu® Sunshield daily wear SPF 15 sunscreen. This mineral based sunscreen provides broad-spectrum protection from sun damage caused by UVA/UVB rays, while fighting the signs of aging through a unique combination of anti-glycation agents, antioxidants, moisturizing elements, peptides, and botanical extracts.

30 Mar 2010

Cumberland Pharmaceuticals submits Acetadote sNDA for non-acetaminophen acute liver failure

Cumberland Pharmaceuticals Inc. has submitted a supplemental new drug application (sNDA) to the U.S. Food and Drug Administration for the use of Acetadote® (acetylcysteine) Injection in patients with non-acetaminophen acute liver failure. Acetadote was launched by Cumberland in 2004 as the first U.S.-approved injectable drug to treat acetaminophen overdose.

30 Mar 2010

Virginia Tech professor receives NSF CAREER award for research on cancer therapies using nanotechnology

Preliminary research on cancer treatments using nanotechnology and laser therapy has led to a National Science Foundation (NSF) Faculty Early Career Development (CAREER) award for Marissa Nichole Rylander, Virginia Tech assistant professor jointly appointed in the Department of Mechanical Engineering and Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences (SBES).

30 Mar 2010

Healthy hearts: Interventions needed to keep people exercising following cardiac rehabilitation programs

Researchers from the Frances Payne Bolton School of Nursing at Case Western Reserve University found that one year after 248 individuals completed a 12-week cardiac rehabilitation program following a heart attack, bypass surgery or angioplasty, only 37% exercised three times a week to keep their hearts healthy.

30 Mar 2010

Insight into scorpion venom may help understand diseases like pancreatitis

A Brazilian scorpion has provided researchers at North Carolina State University and East Carolina University insight into venom's effects on the ability of certain cells to release critical components. The findings may prove useful in understanding diseases like pancreatitis or in targeted drug delivery.

30 Mar 2010

Study suggests two distinct versions of multiple sclerosis

There may be two distinct versions of multiple sclerosis, a study in both animal models and human blood samples suggests. What's more, a patient's responsiveness to the most popular first-line drug for this episodic and all-too-often recurring autoimmune condition seems to depend on which version that patient has.

30 Mar 2010

Chocolate can lower blood pressure and reduce risk of heart disease: Study

Easter eggs and other chocolate may be good for you - at least in small quantities and preferably if it's dark chocolate - according to research that shows just one small square of chocolate a day can lower your blood pressure and reduce your risk of heart disease. The study is published online today (Wednesday 31 March) in the European Heart Journal.

30 Mar 2010

Development and validation process of Rosetta Genomics' miRview mets published

Rosetta Genomics, Ltd., a leading developer and provider of microRNA-based molecular diagnostics, announces publication of an article describing the development and validation process of miRview™ mets, the company's microRNA-based test for identification of primary origin of metastases.

30 Mar 2010

Gout incidence lower in women than men: Study

Researchers from Boston University School of Medicine found that women with serum uric acid levels over 5 mg/dl had a significantly lower risk of developing gout than men. This study, the first to examine the relationship between uric acid levels and gout risk in women, also evaluated purported risk factors for gout and found that increasing age, obesity, hypertension, alcohol use, and diuretic use to be among leading contributors for women.

30 Mar 2010

Analysis indicates substantial underdiagnosis of obesity when BMI used compared to DEXA scan

A retrospective analysis of 1,234 Americans indicated a substantial underdiagnosis of obesity when Body Mass Index was used compared to the Dual Energy X-ray Absorptiometry scan. This analysis will be released on Friday, April 23, 2010 at the American Association of Clinical Endocrinologists 19th Annual Meeting & Clinical Congress in Boston.

30 Mar 2010

Plaques in blood vessels may break by overproducing protein-digesting enzymes

University of Washington (UW) researchers have gathered evidence that dangerous plaques in blood vessels can rupture by overproducing protein-digesting enzymes. Plaques are fat-laden rough spots in the otherwise smooth walls of arteries. When a plaque ruptures, blood accumulates inside of it, a process known as plaque hemorrhage. The plaque enlarges and artery-blocking clots can form. If the flow of oxygen-rich blood is restricted, a heart attack, stroke, or damage to other organs can occur.

30 Mar 2010

'Because Life is for Living' campaign launched to raise awareness about brachytherapy

Former England Rugby World Cup winner Matt Dawson today launched the 'Because Life is for Living' campaign to raise awareness about brachytherapy, a very precise and highly effective form of radiotherapy to treat cancer.

30 Mar 2010

Fecal incontinence: Sacral nerve stimulation along with Medtronic InterStim Therapy promising

Data published in the March issue of the Annals of Surgery show that investigational use of sacral nerve stimulation with Medtronic InterStim® Therapy reduces fecal incontinent episodes and increases quality of life in patients with the condition. The 120-patient, multi-center study - the largest trial of its kind in the world and the first such trial in North America - examined the efficacy of InterStim Therapy in patients with chronic fecal incontinence who had failed or were not candidates for more conservative treatments.

30 Mar 2010

Mutations in gene protecting body leads to development of cancer

An important gene that normally protects the body against cancer can itself cause a variety of cancers depending on the specific mutation that damages it, according to a new study by investigators at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James).

30 Mar 2010

Medical Condition News

Two Phase I studies of Stedivaze demonstrate safety in patients with asthma and COPD

Savient Pharmaceuticals' resubmission of BLA for KRYSTEXXA accepted for FDA review

Neuroscientists prevent memory loss in fruit flies by blocking activity of PI3 kinase signaling protein

Genetically manipulating rats to emulate Alzheimer's disease in humans

Campbell Soup honored for commitment to food allergy safety, awareness and education

Mood altering effects of Phenytoin

Wellness Formulations introduces Dermal Renu Sunshield

Cumberland Pharmaceuticals submits Acetadote sNDA for non-acetaminophen acute liver failure

Virginia Tech professor receives NSF CAREER award for research on cancer therapies using nanotechnology

Healthy hearts: Interventions needed to keep people exercising following cardiac rehabilitation programs

Insight into scorpion venom may help understand diseases like pancreatitis

Study suggests two distinct versions of multiple sclerosis

Chocolate can lower blood pressure and reduce risk of heart disease: Study

Development and validation process of Rosetta Genomics' miRview mets published

Gout incidence lower in women than men: Study

Analysis indicates substantial underdiagnosis of obesity when BMI used compared to DEXA scan

Plaques in blood vessels may break by overproducing protein-digesting enzymes

'Because Life is for Living' campaign launched to raise awareness about brachytherapy

Fecal incontinence: Sacral nerve stimulation along with Medtronic InterStim Therapy promising

Mutations in gene protecting body leads to development of cancer

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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