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TYK2 inhibition may offer new strategy to reduce tau toxicity in Alzheimer's

Researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions discovered that the enzyme TYK2 transforms the normal protein tau into one that accumulates in the brain and contributes to the development of Alzheimer's disease in animal models.

12 Nov 2024

Wellbeing in the USA shows significant disparities, driven by race, sex, age, and location

A study reveals significant disparities in wellbeing across the U.S., influenced by race, ethnicity, and geography, affecting education, income, and lifespan.

12 Nov 2024

Key reason why some cancers do not respond to immunotherapy identified

Research reveals SLC13A3's role in tumor cell survival and immune therapy resistance, highlighting its potential as a target for improved cancer treatments.

12 Nov 2024

New calculator predicts epilepsy risk after venous stroke

A practical calculator that predicts the risk of epilepsy after venous stroke is presented in a study from the University of Gothenburg and others. The aim is to improve care for those affected, which are predominantly young adults.

12 Nov 2024

Switching from smoking to vaping improves respiratory health

A new paper in Nicotine and Tobacco Research, published by Oxford University Press, finds that people who switch from smoking cigarettes to vaping see improved respiratory health, but people who begin consuming electronic cigarettes while continuing to smoke regular cigarettes do not report improved respiratory symptoms.

12 Nov 2024

Extra hour of weekly exercise reduces risk of atrial fibrillation

Adding an extra hour every week of physical activity may lower the chance of developing the most common type of irregular heartbeat (arrythmia) by 11 percent, a new study shows.

12 Nov 2024

Study identifies key priorities for research on reducing psychiatric medication

Study hopes to inform the research agenda and help future research to focus on the questions that are most important to key stakeholders.

12 Nov 2024

Scientists uncover a previously unrecognized tumor suppression mechanism

There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied due to their critical role in disease.

12 Nov 2024

Patient-derived organoids: Transforming cancer research and personalized medicine

Patient-derived organoids (PDOs) are revolutionizing cancer research, enhancing drug testing and personalized treatment through advanced 3D modeling techniques.

12 Nov 2024

Pandemic stress linked to long-term rise in alcohol consumption

Alcohol use increased during the COVID-19 pandemic and remained elevated even after the pandemic ended, according to a large nationally representative Keck Medicine of USC study published today in the Annals of Internal Medicine.

12 Nov 2024

Pfizer-BioNTech vaccine provides strong protection against MIS-C in children aged 5–17

Research indicates the Pfizer-BioNTech vaccine effectively reduces MIS-C incidence in children, supporting vaccination as a critical public health measure.

12 Nov 2024

Limited impact of prenatal COVID-19 exposure on child neurodevelopmental outcomes

Research shows prenatal exposure to SARS-CoV-2 linked to slight regulatory behavior improvements in infants, but no significant neurodevelopmental impacts.

12 Nov 2024

Mursla Bio joins leading European consortium to advance clinical applications based on extracellular vesicle science

Mursla Bio, a leader in Extracellular Vesicle (EV) science on a mission to significantly improve cancer outcomes for at-risk patients through the power of dynamic biopsy technology, announced it has been invited to join EVEREST, a leading European consortium.

From Mursla Bio 12 Nov 2024

Ultra-processed food linked to weight gain and lower well-being in adolescents

Investigating ultra-processed food and screen time, this study examines their effects on weight and well-being in adolescents, considering maternal education.

12 Nov 2024

MethylGPT unlocks DNA secrets for age and disease prediction

Researchers developed MethylGPT, a powerful transformer-based model that identifies DNA methylation patterns, enabling advanced age and disease prediction with clinical potential.

11 Nov 2024

Revolutionary AI predicts aging and disease from DNA patterns

Researchers developed CpGPT, a novel foundation model for DNA methylation analysis that captures sequence, positional, and epigenetic context to predict aging and disease risks. This model offers breakthroughs in imputing missing data and improving mortality and morbidity predictions.

11 Nov 2024

Cannabinol enhances sleep in rats, study shows

Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep.

11 Nov 2024

Overtreatment of older men with prostate cancer raises concerns

Increasing percentages of some older U.S. men with intermediate-risk and high-risk prostate cancers are undergoing treatments that carry risks of side effects that can significantly reduce the quality of life without extending life, according to a new study led by Cedars-Sinai.

11 Nov 2024

Study shows how a single defective BRCA1 gene accelerates cancer development

People inherit two copies of each gene -; one from each parent -; an evolutionary fail-safe to ensure survival even when one of them doesn't function.

11 Nov 2024

Early RSV vaccination in pregnancy provides best protection for newborns

Current guidelines recommend that pregnant people receive a vaccine against respiratory syncytial virus (RSV)-;which typically causes mild, cold-like symptoms in most adults but can be deadly for infants-;during weeks 32–36 of pregnancy.

11 Nov 2024