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Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

A study in The Journal of Cell Biology by scientists at the University of Massachusetts Medical School reveals important new details about the inner workings of the CRISPR-Cas9 machinery in live cells that may have implications for the development of therapeutics that use the powerful gene editing tool.

30 Aug 2016

Novel compound provides safe, effective pain relief with zero abuse potential in animal model

Since the isolation of morphine from opium in the 19th century, scientists have hoped to find a potent opioid analgesic that isn't addictive and doesn't cause respiratory arrest with increased doses.

30 Aug 2016

Study highlights burden of increasing patient volume in emergency departments

The average monthly emergency department visit increased by 5.7 percent in Illinois after the implementation of the Affordable Care Act, although the population remained essentially flat.

30 Aug 2016

CE-MARC 2 trial finds way to reduce rates of unnecessary invasive angiography

Initial investigation of patients with suspected coronary heart disease (CHD) using functional imaging - rather than guideline-directed care - resulted in significantly less unnecessary angiography, according to results of the CE-MARC 2 trial.

30 Aug 2016

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents.

30 Aug 2016

Researchers find better way to purify liver cells made from induced pluripotent stem cells

A research team including developmental biologist Stephen A. Duncan, D. Phil., SmartState Chair of Regenerative Medicine at the Medical University of South Carolina, has found a better way to purify liver cells made from induced pluripotent stem cells (iPSCs).

30 Aug 2016

Penn scientists find striking similarities between human patients with LCA and dogs

Ciliopathies are diseases that affect the cilia, sensory organelles that most mammalian cells possess and which play a critical role in many biological functions.

30 Aug 2016

Nebivolol treatment may protect against antracycline-induced cardiotoxicity in breast cancer patients

Nebivolol prevents anthracycline-induced cardiotoxicity, according to research presented at ESC Congress 2016 today by Professor Mirela Cleopatra Tomescu, a cardiologist at Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

30 Aug 2016

Study examines link between PTSD and cognitive impairment in WTC responders without head injury

New research published by the journal Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring confirms the connection between posttraumatic stress disorder (PTSD) and cognitive impairment - in this case, among those who helped with search, rescue and cleanup efforts following the 2001 World Trade Center (WTC) attacks.

30 Aug 2016

CPAP treatment offers no cardiovascular benefit in OSA patients with heart disease risk

More than 3 years of nightly treatment with a continuous positive airway pressure (CPAP) machine did not reduce cardiovascular risk more than usual care among patients with cardiovascular disease and obstructive sleep apnea (OSA).

30 Aug 2016

New study examines potential weight management benefits of sit-stand desks

Alternating positions between standing and sitting while performing deskwork could make the difference in whether the thin red needle in your bathroom scale tilts to the left or the right of your goal weight.

30 Aug 2016

Researchers find high levels of neurotoxins linked to Alzheimer's, ALS in fins and muscles of sharks

In a new study, University of Miami scientists found high concentrations of toxins linked to neurodegenerative diseases in the fins and muscles of 10 species of sharks.

30 Aug 2016

CFS possesses objectively identifiable chemical signature in men and women, study reveals

Dauer is the German word for persistence or long-lived. It is a type of stasis in the development in some invertebrates that is prompted by harsh environmental conditions. The findings are published online in the August 29 issue of PNAS.

29 Aug 2016

Integrating mental and physical healthcare leads to better clinical outcomes, lower costs

A major new study shows that delivering integrated mental and physical healthcare in team-based primary care settings at Intermountain Healthcare results in better clinical outcomes for patients, lower rates of healthcare utilization, and lower costs.

29 Aug 2016

Lens doesn't compensate for astigmatic defocus of the eye, study reveals

For people with nearsightedness (myopia), the lens doesn't compensate for growth or other changes in the structure of the eye, according to a long-term follow-up study in the September issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Wolters Kluwer.

29 Aug 2016

Study finds tight glycemic control provides no impact on patient-important microvascular outcomes

The glucocentric focus on lowering blood sugar in Type 2 diabetes may have short-circuited development of new diabetes therapies, according to a new paper published by Mayo Clinic researchers in the journal Circulation: Cardiovascular Quality and Outcomes.

29 Aug 2016

New research finds decrease in brain blood flow after stopping exercise in healthy older adults

We all know that we can quickly lose cardiovascular endurance if we stop exercising for a few weeks, but what impact does the cessation of exercise have on our brains? New research led by University of Maryland School of Public Health researchers examined cerebral blood flow in healthy, physically fit older adults (ages 50-80 years) before and after a 10-day period during which they stopped all exercise.

29 Aug 2016

Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

In microseconds, every light ray that enters the eye triggers an explosion of coordinated cellular events.

29 Aug 2016

Study finds football players may suffer from heat-related illness during first two weeks of practice

As the college football season heats up, a new University of Georgia study finds players are more likely to suffer from heat-related illness during the first two weeks of practice, especially those in the Southeast.

29 Aug 2016

Outpatient CLABSIs costly for pediatric stem cell transplant and oncology patient population

Pediatric stem cell transplant and cancer patients often are discharged from the hospital with an external central venous line for medications that parents or other caregivers must clean and flush daily to avoid potentially life-threatening infections.

29 Aug 2016

Medical Research News

Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

Novel compound provides safe, effective pain relief with zero abuse potential in animal model

Study highlights burden of increasing patient volume in emergency departments

CE-MARC 2 trial finds way to reduce rates of unnecessary invasive angiography

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

Researchers find better way to purify liver cells made from induced pluripotent stem cells

Penn scientists find striking similarities between human patients with LCA and dogs

Nebivolol treatment may protect against antracycline-induced cardiotoxicity in breast cancer patients

Study examines link between PTSD and cognitive impairment in WTC responders without head injury

CPAP treatment offers no cardiovascular benefit in OSA patients with heart disease risk

New study examines potential weight management benefits of sit-stand desks

Researchers find high levels of neurotoxins linked to Alzheimer's, ALS in fins and muscles of sharks

CFS possesses objectively identifiable chemical signature in men and women, study reveals

Integrating mental and physical healthcare leads to better clinical outcomes, lower costs

Lens doesn't compensate for astigmatic defocus of the eye, study reveals

Study finds tight glycemic control provides no impact on patient-important microvascular outcomes

New research finds decrease in brain blood flow after stopping exercise in healthy older adults

Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

Study finds football players may suffer from heat-related illness during first two weeks of practice

Outpatient CLABSIs costly for pediatric stem cell transplant and oncology patient population

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

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