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New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

A research team led by an award-winning genomicist at Western University has developed a new method for identifying mutations and prioritizing variants in breast and ovarian cancer genes, which will not only reduce the number of possible variants for doctors to investigate, but also increase the number of patients that are properly diagnosed.

29 Apr 2016

Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016

Changes in the brain make people prone to alcoholism

The brain tissue of persons with alcohol dependence shows a variety of changes compared to non-alcoholic control persons. All alcoholics' brains share some characteristics, but some are exclusive to the brain tissue of anxiety-prone type 1 alcoholics or impulsive type 2 alcoholics, according to a recent study from the University of Eastern Finland.

29 Apr 2016

People diagnosed with psoriatic arthritis often left with little or no support for emotional problems

In a new University of Manchester study, people with psoriatic arthritis have told researchers about the condition's deeply damaging mental effects and how healthcare services failed to prepare them for its reality.

29 Apr 2016

Studies on role of vitamin A in heart health have drawn opposite conclusions

Vitamin A is involved in many bodily processes, including vision and skin health, but its role in the heart is unclear. While vitamin A is critical for heart development of embryos—vitamin A deficiency during pregnancy leads to an abnormal heart and prenatal death—studies on vitamin A's role in heart health have drawn opposite conclusions.

29 Apr 2016

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

A new version of an obesity drug that caused serious psychiatric side effects could help people lose pounds without experiencing the anxiety, depression and suicidal thoughts previously associated with it. The research, published in Bioorganic and Medicinal Chemistry, shows that the new version of the drug can still work without reaching the brain in rats, avoiding the side effects.

29 Apr 2016

Pioneering gene therapy may lead to potential cure for common causes of vision loss

Pioneering gene therapy has restored some vision to patients with a rare form of genetic blindness for as long as four years, raising hopes it could be used to cure common causes of vision loss, new University of Oxford research published today shows.

29 Apr 2016

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, and Vanderbilt University. The group published their findings this month in npj Genomic Medicine.

29 Apr 2016

Gut bacteria linked to risk of bloodstream infections after chemotherapy

A new study led by researchers at the University of Minnesota and Nantes University Hospital in France shows that the bacteria in people's gut may predict their risk of life-threatening blood infections following high-dose chemotherapy.

29 Apr 2016

Structured transitional stroke care could decrease hospital readmission rates

A transitional stroke clinic developed by doctors and nurse practitioners at Wake Forest Baptist Medical Center reduced 30-day readmission rates by 48 percent, according to a study published in the April 28 online issue of the journal Stroke.

29 Apr 2016

Key gene changes reveal four previously unknown conditions within schizophrenia

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal. Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

29 Apr 2016

Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

While the Fontan procedure has improved the short- and mid-term outcomes for patients born with single ventricle anatomy, long-term complications of Fontan circulation include heart failure. These complications are thought to be secondary to elevated central venous pressure, chronic venous congestion and low cardiac output.

29 Apr 2016

Integrating fiber optic biosensor into microfluidic chip may help in early diagnosis of diabetes

Insulin deficiency and hyperglycemia are two well-known culprits behind diabetes, both of which are reflected in blood glucose concentrations. Now, researchers are working to create ultrasensitive lab-on-a-chip devices to quickly measure glucose concentrations with the goal of developing device for early diagnosis and prevent of diabetes

29 Apr 2016

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson's disease.

29 Apr 2016

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

For smokers who are addicted to alcohol, chronic alcohol abuse may increase the rate of nicotine metabolism and contribute to poor smoking cessation rates. When smokers stop drinking the nicotine metabolism rates decline significantly, according to a study conducted by an international research team led by Roswell Park Cancer Institute. The research was a collaboration of scientists from Roswell Park, the University of California, San Francisco, and the Medical University of Silesia and Center of Addiction Treatment in Poland.

29 Apr 2016

Daily chocolate consumption may improve cardio-metabolic health

A new study published in the British Journal of Nutrition appears to back up the adage that a little of what you fancy does you good.

29 Apr 2016

Extreme weather events may lead to more asthma hospitalization

Extreme heat and heavy rainfall are related to increased risk of hospitalization for asthma in Maryland, according to a study by University of Maryland School of Public Health researchers.

29 Apr 2016

New fluorescent chemical probes that measure enzyme levels can diagnose inherited genetic disorders

Scientists at the Universities of York and Leiden have made a significant breakthrough in the treatment of an inherited genetic disorder which damages muscle and nerve cells in the body.

29 Apr 2016

Effects of BPA on embryos in females undergoing IVF

Bisphenol A (BPA) is an industrial chemical that is used in a variety of consumer products, such as water bottles, metal food and beverage containers, and thermal paper cash register receipts.

29 Apr 2016

Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

A new study shows that black raspberry extract can significantly lower a key measure of arterial stiffness-an indicator of cardiovascular disease. Black raspberry intake was also associated with increased levels of circulating endothelial progenitor cells (EPCs), which help repair and regenerate damaged arteries, according to the study published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Medicinal Food website until May 28, 2016.

29 Apr 2016

Medical Research News

New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

Understanding how individuals respond to aspirin

Changes in the brain make people prone to alcoholism

People diagnosed with psoriatic arthritis often left with little or no support for emotional problems

Studies on role of vitamin A in heart health have drawn opposite conclusions

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

Pioneering gene therapy may lead to potential cure for common causes of vision loss

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

Gut bacteria linked to risk of bloodstream infections after chemotherapy

Structured transitional stroke care could decrease hospital readmission rates

Key gene changes reveal four previously unknown conditions within schizophrenia

Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

Integrating fiber optic biosensor into microfluidic chip may help in early diagnosis of diabetes

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

Daily chocolate consumption may improve cardio-metabolic health

Extreme weather events may lead to more asthma hospitalization

New fluorescent chemical probes that measure enzyme levels can diagnose inherited genetic disorders

Effects of BPA on embryos in females undergoing IVF

Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

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