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Ultra-performance chromatography test aids bosutinib plasma quantification

Chinese scientists have developed a fast and sensitive method for the quantification of the tyrosine kinase inhibitor bosutinib in rat blood samples.

27 Nov 2015

Epilepsy common but variable in mitochondrial disease patients

Around a quarter of patients with mitochondrial diseases have seizures, but these do not appear to increase their risk of dying, report researchers.

27 Nov 2015

Comorbidities relevant to CML TKI choice common

Comorbid conditions that could affect the choice of tyrosine kinase inhibitor are common in patients with chronic myeloid leukaemia, finds an analysis of a US claims database.

27 Nov 2015

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Four-year results for an ongoing study of second-line bosutinib indicate that the tyrosine kinase inhibitor offers long-term efficacy with manageable side effects for patients with chronic phase chronic myeloid leukaemia.

27 Nov 2015

Rare variants linked with Parkinson’s disease

Researchers using exome sequencing in families with Parkinson’s disease have identified two genes that could be associated with the condition.

27 Nov 2015

Incidence of HIV in Europe reaches record high

Results of recent surveillance conducted by the European Centre for Disease Prevention and Control (ECDC) and the WHO Regional Office for Europe indicate that the annual number of newly diagnosed HIV infections in Europe reached an all-time high in 2014.

27 Nov 2015

Discovery opens up new avenue for research on potential treatments for Alzheimer's disease

A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer's disease - work that opens up a new avenue for research on possible treatments for the degenerative brain condition.

27 Nov 2015

New combination approach to eradicate established tumors

A laboratory study conducted at Leiden University Medical Center in the Netherlands has found that immunotherapy can be efficiently combined with photodynamic therapy (PDT) to eradicate established tumors. The approach results in strong local tumor destruction and a robust systemic immune response against the disease.

27 Nov 2015

Older patients can recover from acute subdural hematomas

According to a study completed at the Helsinki University Hospital Department of Neurosurgery, even patients over the age of 75 may recover from severe traumatic brain injury. This is the first study to describe the results of surgically treated elderly patients with acute subdural hematomas.

27 Nov 2015

New study reveals effect of cannabis potency on brain structure

Smoking high potency 'skunk-like' cannabis can damage a crucial part of the brain responsible for communication between the two brain hemispheres, according to a new study by scientists from King's College London and Sapienza University of Rome.

27 Nov 2015

Cognitive behavioural therapy benefits people with dental phobia

Cognitive behavioural therapy could help many people with a dental phobia overcome their fear of visiting the dentist and enable them to receive dental treatment without the need to be sedated, according to a new study by King's College London.

27 Nov 2015

Experts list top 10 research priorities for tackling hearing loss

Experts have published a list of the most urgent priorities for researching a debilitating condition that affects more than 10 million people in the UK.

27 Nov 2015

European and North American blood pressure guidelines may increase stroke risk in older Asian patients

European and North American blood pressure guidelines, issued last year, may actually boost the stroke risk if used for Asian patients, particularly the elderly, suggests an expert opinion published online in the journal Heart Asia.

27 Nov 2015

Structured personal diabetes care improves outcomes in women

A follow-up study to assess the effects of personally tailored diabetes care in general practice has revealed that such care reduces mortality (both all-cause and diabetes-related), in women, but not men. The study is by Dr Marlene Krag, The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Denmark, and colleagues, and is published in Diabetologia, the journal of the European Association for the Study of Diabetes.

27 Nov 2015

Survey: More than 1 in 4 middle-aged Indians on low and middling incomes carry unhealthy midriff bulge

More than one in four middle-aged Indians on low and middling incomes now has an unhealthy midriff bulge, with women most likely to carry a spare tyre, reveal the results of a nationally representative survey, published in the online journal BMJ Open.

27 Nov 2015

Scientists show how malaria parasites invade the liver

Scientists at the Center for Infectious Disease Research recently uncovered a critical piece in the puzzle of how malaria parasites infect their host. The work, recently published in Science Magazine, reveals the details of how the malaria parasite invades its initial target organ, the liver. Without infection of the liver, the parasites cannot multiply or spread to the blood. Infection of the blood causes illness, spread of the disease, and, ultimately, death.

27 Nov 2015

Specific environmental influences can neutralize effect of genetic variant that increases childhood asthma risk

The effect of a widespread genetic variant that increases the risk for childhood asthma can be neutralized. A new study shows that young infants are particularly responsive to the positive influence of exposure to farm dust.

27 Nov 2015

Researchers reveal new technique to grow human hepatocytes in the laboratory

In new research appearing in the prestigious journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations.

27 Nov 2015

Progesterone supplements fail to improve birth rate among women with a history of miscarriage

A new study has shown that taking progesterone supplements during the first trimester of pregnancy does not improve the chances of maintaining pregnancy among women who have a history of unexplained recurrent miscarriage.

26 Nov 2015

New test can detect drug abuse faster

A new test for club drugs like ketamine can detect low levels of drugs in urine and plasma, making it faster, easier and cheaper to identify them. The authors of the study, published in Journal of Chromatography B, say it could give authorities the boost they need to keep up with trends drug (ab)use.

26 Nov 2015