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York U researchers identify how living beings can keep gene expression in check

York University researchers have learned how living beings can keep gene expression in check -- which might partly explain the uncontrolled gene expression found in many cancers.

16 Mar 2015

Exposure to diesel exhaust may exacerbate respiratory diseases

Researchers in the UK have, for the first time, shown how exhaust pollution from diesel engines is able to affect nerves within the lung. Air pollution is a significant threat to health, they say, and identifying potential mechanisms linking exposure to diesel exhaust and the exacerbation of respiratory diseases may lead to treatments for those affected.

16 Mar 2015

MGH study suggests that bariatric surgery can reduce risk of asthma attacks

A study led by Massachusetts General Hospital investigators suggests that bariatric surgery can significantly reduce the risk of asthma attacks - also called exacerbations - in obese patients with asthma.

16 Mar 2015

Study sheds light on cell migration mechanisms involved in wound-healing process

Researchers at the University of Arizona have discovered what causes and regulates collective cell migration, one of the most universal but least understood biological processes in all living organisms.

16 Mar 2015

Mechanistic subtypes of IPAH revealed

Researchers have provided evidence for distinct processes underlying vasodilator-responsive and nonresponsive idiopathic pulmonary arterial hypertension.

13 Mar 2015

Combining CT measurements assists pulmonary hypertension prediction

Research suggests that combining pulmonary artery and ventricular measurements improves the chances of identifying pulmonary hypertension in patients undergoing computed tomography pulmonary angiography.

13 Mar 2015

Metabolic derangement may facilitate cell proliferation in PAH

An enzyme that facilitates modification of proteins via a glucose metabolism pathway may promote cell proliferation in the lung tissue of patients with idiopathic pulmonary arterial hypertension, say researchers.

13 Mar 2015

Prognostic potential for pericardial effusion in PAH patients

Monitoring pericardial effusion on serial transthoracic echocardiograms provides useful prognostic information in patients with pulmonary arterial hypertension, research suggests.

13 Mar 2015

Randomised trial puts FINGER on cognitive health

The FINGER study, the first large randomised, controlled trial of its kind, suggests that a multifactorial intervention could slow cognitive decline in elderly people at risk of developing dementia.

13 Mar 2015

Long-term entecavir, TDF effective in chronic HBV in real-world setting

A Turkish clinical practice study shows that entecavir and tenofovir disoproxil fumarate can effectively maintain long-term virological and biochemical responses in patients with chronic hepatitis B virus infection, both in those with and without cirrhosis.

13 Mar 2015

Factors predictive of sequential nucleos(t)ide analogue, IFN-α therapy response identified

Hepatitis B surface antigen and hepatitis B core-related antigen levels can predict long-term response to sequential nucleos(t)ide analogue and interferon-α therapy in patients with chronic hepatitis B virus infection, research indicates.

13 Mar 2015

GH response poor in SGA children with good spontaneous catch-up growth

Spontaneous catch-up growth after birth in short children who were born small for gestational age is a negative predictor of their long-term response to growth hormone treatment, say researchers.

13 Mar 2015

Blunted cortisol response common in non-classic CAH

Nearly two-thirds of children with non-classic congenital adrenal hyperplasia have an inadequate cortisol response, report researchers.

13 Mar 2015

Nomogram aids management of boys with constitutional delay in growth and puberty

A puberty nomogram is better than the classical criteria for identifying boys with constitutional delay in growth and puberty, report researchers.

13 Mar 2015

No adulthood metabolic consequences of central precocious puberty

Researchers have found that girls with central precocious puberty have similar metabolic and general health to other women when they reach young to middle adulthood.

13 Mar 2015

Islet autoantibody levels predict progression to diabetes

Levels of insulin autoantibodies and insulinoma-associated protein 2 autoantibodies predict the onset of diabetes in young children with islet autoimmunity, show findings from the TEDDY study.

13 Mar 2015

Creatine monohydrate disappoints in Parkinson’s disease

Creatine monohydrate fails to live up to its early promise in patients with Parkinson’s disease, show the results of the Long-term Study 1.

13 Mar 2015

HBV genotype C HBeAg seroconversion rate ‘negligible’

Patients with chronic hepatitis B virus genotype C infection who are positive for hepatitis B e antigen should not delay antiviral treatment in the hope of seroconversion, Korean researchers recommend.

13 Mar 2015

Super-resolution microscopes reveal the link between genome packaging and cell pluripotency

In 1953 Watson and Crick first published the discovery of the double helix structure of the DNA. They were able to visualize the DNA structure by means of X-Ray diffraction. Techniques, such as electron microscopy, allowed scientists to identify nucleosomes, the first and most basic level of chromosome organisation

13 Mar 2015

New study finds no connection between hip width and efficient locomotion

Among the facts so widely assumed that they are rarely, if ever studied, is the notion that wider hips make women less efficient when they walk and run.

13 Mar 2015