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Lin28 gene may hold clues to regeneration of damaged kidneys in adults

Nearly one-third of cases of Wilms tumor, a pediatric cancer of the kidney, are linked to a gene called Lin28, according to research from Boston Children's Hospital. Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.

15 Apr 2014

Scientists receive grant from Biogen Idec to study everyday activities in MS using actual reality

John DeLuca, PhD, and Yael Goverover, PhD, OT, have received a grant from Biogen Idec to study how persons with multiple sclerosis (MS) perform everyday life tasks. The grant, entitled "The Use of Actual Reality to Measure Everyday Life Functional Activity in Multiple Sclerosis" provides financial support to conduct this research.

15 Apr 2014

Radiation plus hormones offers best outcomes for localised prostate cancer

The combination of radiotherapy and androgen deprivation therapy is more effective than radiotherapy alone for preventing disease recurrence in men with localised prostate cancer, according to research findings presented at the European Society for Radiotherapy and Oncology 33rd annual congress in Vienna, Austria.

14 Apr 2014

S. pneumoniae serotypes differ between primary and post-viral disease

Certain capsular serotypes of Streptococcus pneumoniae are particularly likely to cause disease in people who have recently experienced a respiratory viral infection, study findings indicate.

14 Apr 2014

Three-gene test may aid earlier lung cancer detection

Methylation of three genes may help with the early diagnosis of non-small-cell lung cancer, research suggests.

14 Apr 2014

Adjuvant radiotherapy after prostatectomy ‘risks urinary incontinence’

Men who receive adjuvant radiation therapy following radical prostatectomy face a significantly increased risk of urinary incontinence in the following years, study findings indicate.

14 Apr 2014

Ceritinib ‘highly active’ in advanced ALK-rearranged NSCLC

Phase I study findings suggest the investigational drug ceritinib is effective in patients with advanced non-small-cell lung cancer with anaplastic lymphoma kinase gene rearrangement, even in those who develop resistance to crizotinib.

14 Apr 2014

Variability in SBP portends cognitive decline

Findings from the Ohasama study reveal an association between variability in home systolic blood pressure and cognitive decline.

14 Apr 2014

Two candidate mTOR therapy biomarkers identified in RCC

Two genes, TSC1 and MTOR, warrant further investigation as biomarkers for treatment benefit with rapalogs in patients with renal cell carcinoma, indicate study results published in Clinical Cancer Research.

14 Apr 2014

Amrubicin regimen inferior to irinotecan for extensive SCLC

Irinotecan plus cisplatin remains the gold standard for Japanese patients with extensive small-cell lung cancer, say researchers, after amrubicin plus cisplatin failed to improve survival in their randomised phase III trial.

11 Apr 2014

1/4 human tumor exist genetic polymorphisms linked with increased risk of cancer

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes.

11 Apr 2014

Study confirms neurobiological origin of attention-deficit disorder

A study, carried out on mice, has just confirmed the neurobiological origin of attention-deficit disorder (ADD), a syndrome whose causes are poorly understood. Researchers from CNRS, the University of Strasbourg and INSERM1 have identified a cerebral structure, the superior colliculus, where hyperstimulation causes behavior modifications similar to those of some patients who suffer from ADD.

11 Apr 2014

ICB International develops tracer for imaging alpha-synuclein in Parkinson's disease

On March 4, 2014, ICB International, Inc., ("ICBI"), announced the development of a tracer for imaging alpha-synuclein (a-Syn) in Parkinson's-like mice at the Keystone Symposium for Parkinson disease (PD) in Keystone,Colorado.

11 Apr 2014

Researchers identify eight new active molecules against Alzheimer

Researchers of the Unit of Medicine Design and Molecular Topology (Department of Physics Chemistry) of the University of Valencia have discovered eight new active molecules against Alzheimer by a novel mechanism of action, different to the currently used medicines. The work has just been published in the "Plos One" magazine.

11 Apr 2014

Study suggests nestin+ cholinergic neurons may have closer connection to olfactory bulb neurons

Dr. Yuhong Zhao and co-workers from Sun Yat-sen University in China explored the projection of nestin+ neurons to the olfactory bulb and the time course of nestin+ neurons in the medial septum-diagonal band of Broca in adult rats during injury recovery after olfactory nerve transection.

11 Apr 2014

Researchers uncover new aspect of autism

A team of researchers from the University of California, San Diego School of Medicine and the Center for Cancer Systems Biology at the Dana-Farber Cancer Institute has uncovered a new aspect of autism, revealing that proteins involved in autism interact with many more partners than previously known. These interactions had not been detected earlier because they involve alternatively spliced forms of autism genes found in the brain.

11 Apr 2014

Scientists shed light on runny nose

Scientists at the University of Colorado School of Medicine have shed light on one of the most common of ailments - the runny nose.

11 Apr 2014

Study shows link between overuse injury rates in young athletes and their socioeconomic status

A Loyola University Medical Center study is reporting for the first time a link between overuse injury rates in young athletes and their socioeconomic status.

11 Apr 2014

Loyola study reports link between overuse injury rates and socioeconomic status in young athletes

A Loyola University Medical Center study is reporting for the first time a link between overuse injury rates in young athletes and their socioeconomic status.

11 Apr 2014

Researchers receive Presidential Recognition Awards at AIUM 2014 Annual Convention

Steven Goldstein, MD, President of the American Institute of Ultrasound in Medicine (AIUM), presented Presidential Recognition Awards to David Bahner, MD, RDMS, Bryann Bromley, MD, and Glynis Harvey, CAE, at the AIUM 2014 Annual Convention in Las Vegas, Nevada.

11 Apr 2014