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Study finds persistent deficiency in new therapeutics for neglected diseases

In a study published today in the open-access journal The Lancet Global Health, the Drugs for Neglected Diseases initiative and other researchers report a persistent deficiency in truly new therapeutics for neglected diseases, despite nominal progress and an acceleration in research and development efforts. This continued 'fatal imbalance' in medical R&D points to the urgent need to develop and deliver groundbreaking new treatments for the world's poorest and most neglected patients.

25 Oct 2013

Use of IMRT for prostate cancer doubles when self-referral's financial incentives involved

A comprehensive review of Medicare claims for more than 45,000 patients from 2005 through 2010 found that nearly all of the 146 percent increase in intensity-modulated radiation therapy for prostate cancer among urologists with an ownership interest in the treatment was due to self-referral, according to new research, "Urologists' Use of Intensity-Modulated Radiation Therapy for Prostate Cancer," released today in The New England Journal of Medicine for its October 24, 2013 issue.

25 Oct 2013

Scientists work hard to improve procedures for artificially producing tissue

What sounds like a dream of the future has already been the subject of research for a few years: simply printing out tissue and organs. Now scientists have further refined the technology and are able to produce various tissue types.

25 Oct 2013

MIT researchers design stealth drug delivery system to attack TNBC cells

Some of the most dangerous cancers are those that can outmaneuver the very drugs designed to defeat them, but researchers are now reporting a new Trojan-horse approach. In a preliminary study in the journal ACS Nano focusing on a type of breast cancer that is highly resistant to current therapies, they describe a way to sneak small particles into tumor cells, lower their defenses and attack them with drugs, potentially making the therapy much more effective.

25 Oct 2013

Maternal symptoms of anxiety, depression increase risk of mental health problems in children

Maternal symptoms of anxiety and depression increased the risk of emotional and disruptive problem behaviors in children as early as 18 months of age, according to new research findings from the TOPP study.

25 Oct 2013

Study: Gene Expression Classifier test reduces unnecessary surgeries in thyroid nodule assessment

The latest study co-led by a CU School of Medicine researcher has confirmed that a Gene Expression Classifier (GEC) test can drastically reduce the problem of unnecessary surgeries in thyroid nodule assessment.

25 Oct 2013

Study shows concentration levels of PAHs in smokeless tobacco products

A new study shows that the concentration of polycyclic aromatic hydrocarbons (PAHs) in smokeless tobacco products (STPs) can differ by as much as 60 fold, with the highest levels in moist snuff, and dry snuff and soft pellets; the lowest levels were in snus.

25 Oct 2013

Rice University research reveals 3-way genetic switch for cancer metastasis

Cancer researchers from Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch's dynamics also allows a third choice that lies somewhere between "on" and "off." The extra setting both explains previously confusing experimental results and opens the door to new avenues of cancer treatment.

25 Oct 2013

Research unlocks secrets of mouse behavior to help identify promising psychiatric drugs

Developing psychiatric medications is a long and complex process. Candidate drugs are evaluated and assessed based on their effects on the behavior of animals, usually rats or mice. Each class of drugs, from antidepressants to antipsychotics, is tested differently - often in a labor-intensive process that leaves plenty of room for human error. And there is a growing consensus that current procedures fail to effectively produce new medications.

25 Oct 2013

Just 13 days in space may cause changes in eye structure, gene expression

Just 13 days in space may be enough to cause profound changes in eye structure and gene expression, report researchers from Houston Methodist, NASA Johnson Space Center, and two other institutions in the October 2013 issue of Gravitational and Space Research.

25 Oct 2013

NIH awards $2.4M to develop innovative robots to aid people with visual and physical impairment

Three projects have been awarded funding by the National Institutes of Health to develop innovative robots that work cooperatively with people and adapt to changing environments to improve human capabilities and enhance medical procedures. Funding for these projects totals approximately $2.4 million over the next five years, subject to the availability of funds.

25 Oct 2013

Hypoxia can be detected prior to incapacitating physical symptoms, say researchers

A team of Mayo Clinic researchers have found that hypoxia can be detected prior to incapacitating physical symptoms which can be a safety threat at high altitudes. The findings were published as the lead article in the October issue of Aviation, Space, and Environmental Medicine.

25 Oct 2013

UMMS professor receives EUREKA grant to develop light activated nanoparticles for imaging brain tissue

University of Massachusetts Medical School Assistant Professor of Biochemistry and Molecular Pharmacology Gang Han, PhD, has received a $1.3 million EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant from the National Institute of Mental Health to develop light activated nanoparticles that can be used to image live brain tissue.

25 Oct 2013

Cancer imaging centers receive £35M grant to develop cutting edge imaging technologies

Cancer imaging is set to get a major boost from a -35 million nationwide initiative to develop cutting edge imaging technologies for basic and clinical cancer research.

25 Oct 2013

New study finds association between OSA and subclinical myocardial injury

Obstructive sleep apnea is known to be associated with an increased incidence of cardiovascular disease. Now a new study indicates that OSA is associated with subclinical myocardial injury, as indicated by increased high sensitivity troponin T levels. Elevated hs-TnT levels are predictive of both coronary heart disease and heart failure in the general population.

25 Oct 2013

Researchers measure stiffness of ankle using "Anklebot" robot

For most healthy bipeds, the act of walking is seldom given a second thought: One foot follows the other, and the rest of the body falls in line, supported by a system of muscle, tendon, and bones.

25 Oct 2013

Gene-diet interaction may shed light on increased risk of colorectal cancer linked with meat consumption

A newly discovered potential gene-diet interaction for colorectal cancer was reported today (Thursday, Oct. 24) at the American Society of Human Genetics 2013 meeting in Boston.

25 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

New report explains occurrence of breast cancer in women with normal BRCA genes

Since 1994, many thousands of women with breast cancer from families severely affected with the disease have been tested for inherited mutations in BRCA1 and BRCA2. The vast majority of those patients were told that their gene sequences were normal.

25 Oct 2013

Scientists identify link between rare mutations in RINT1 gene and early onset breast cancer risk

An international team of scientists has identified an association between heritable, rare mutations in the RINT1 gene and increased risk of early onset breast cancer, according to research reported today (Oct. 24) at the American Society of Human Genetics 2013 annual meeting in Boston.

25 Oct 2013

Medical Research News

Study finds persistent deficiency in new therapeutics for neglected diseases

Use of IMRT for prostate cancer doubles when self-referral's financial incentives involved

Scientists work hard to improve procedures for artificially producing tissue

MIT researchers design stealth drug delivery system to attack TNBC cells

Maternal symptoms of anxiety, depression increase risk of mental health problems in children

Study: Gene Expression Classifier test reduces unnecessary surgeries in thyroid nodule assessment

Study shows concentration levels of PAHs in smokeless tobacco products

Rice University research reveals 3-way genetic switch for cancer metastasis

Research unlocks secrets of mouse behavior to help identify promising psychiatric drugs

Just 13 days in space may cause changes in eye structure, gene expression

NIH awards $2.4M to develop innovative robots to aid people with visual and physical impairment

Hypoxia can be detected prior to incapacitating physical symptoms, say researchers

UMMS professor receives EUREKA grant to develop light activated nanoparticles for imaging brain tissue

Cancer imaging centers receive £35M grant to develop cutting edge imaging technologies

New study finds association between OSA and subclinical myocardial injury

Researchers measure stiffness of ankle using "Anklebot" robot

Gene-diet interaction may shed light on increased risk of colorectal cancer linked with meat consumption

Whitehead Institute scientists identify novel Parkinson's disease drug target

New report explains occurrence of breast cancer in women with normal BRCA genes

Scientists identify link between rare mutations in RINT1 gene and early onset breast cancer risk

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves

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