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Molecule produced by brain acts as natural defence mechanism against cannabis

Two INSERM research teams led by Pier Vincenzo Piazza and Giovanni Marsicano (INSERM Unit 862 "Neurocentre Magendie" in Bordeaux) recently discovered that pregnenolone, a molecule produced by the brain, acts as a natural defence mechanism against the harmful effects of cannabis in animals.

3 Jan 2014

UC Davis docs find a way to create "movies" of wrist in motion using magnetic resonance imaging scans

If a picture is worth 1,000 words then a movie is worth far more, especially when it comes to diagnosing wrist problems.

3 Jan 2014

Scientists discover new class of cells expressing olfactory receptors in human airways

Your nose is not the only organ in your body that can sense cigarette smoke wafting through the air. Scientists at Washington University in St. Louis and the University of Iowa have showed that your lungs have odor receptors as well.

3 Jan 2014

Chinese herbal medicine effective at alleviating acute inflammatory and nerve pain

A compound derived from a traditional Chinese herbal medicine has been found effective at alleviating pain, pointing the way to a new nonaddictive analgesic for acute inflammatory and nerve pain, according to UC Irvine pharmacology researchers.

3 Jan 2014

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive mechanisms are not well understood.

3 Jan 2014

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Researchers from Huntsman Cancer Institute (HCI) at the University of Utah discovered a cellular mechanism that drives the spread of breast cancer to other parts of the body (metastasis), as well as a therapy which blocks that mechanism. The research results were published online in the journal Cell Reports on January 2.

3 Jan 2014

Study finds extraordinary link between narcolepsy and specific gene variant

A new study conducted across Europe found an extraordinary association between narcolepsy and a specific gene variant related to the immune system.

2 Jan 2014

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation.

2 Jan 2014

Macrophages invade diabetic pancreatic tissue during early stages of type 2 diabetes

As people's waistlines increase, so does the incidence of type 2 diabetes. Now scientists have a better understanding of exactly what happens in the body that leads up to type 2 diabetes, and what likely causes some of the complications related to the disease. Specifically, scientists from Denmark have found that in mice, macrophages, a specific type of immune cell, invade the diabetic pancreatic tissue during the early stages of the disease.

2 Jan 2014

Computer algorithm developed to identify genes that could be transformed to stop aging process

Restricting calorie consumption is one of the few proven ways to combat aging. Though the underlying mechanism is unknown, calorie restriction has been shown to prolong lifespan in yeast, worms, flies, monkeys, and, in some studies, humans.

2 Jan 2014

Overweight children face increased risk of asthma

Overweight and obesity are significant risk factors for reduced lung function in school-aged children with a history of early childhood wheezing, according to a study carried out at the University of Eastern Finland. The results also showed that the use of inhaled corticosteroids for asthma in childhood may result in reduced bone mineral density in early teenage years.

2 Jan 2014

New research shows that as we age, the thermogenic activity of brown fat gets reduced

As most people resolve themselves to lose weight this New Year, here's why it seems to get easier and easier to pack on unwanted pounds: New research published in the January 2014 issue of The FASEB Journal, shows that as we age, the thermogenic activity of brown fat is reduced. Brown fat is a "good" fat located in the backs of our necks that helps burn "bad" white fat around our bellies. Additionally, the researchers also discovered a possible metabolic on/off switch that could reactivate brown fat.

2 Jan 2014

Shingles may increase risk of stroke in later life, study finds

Having shingles may increase the risk of having a stroke years later, according to research published in the January 2, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology.

2 Jan 2014

Resting-state connectivity and metabolism dissociated in schizophrenia

A neuroimaging study suggests that patients with schizophrenia have difficulty deactivating the default mode network, rather than having increased absolute metabolic activity.

2 Jan 2014

Family history points to more severe bipolar disorder

A family history of mood disorders is associated with more severe symptoms at presentation and a poorer clinical course in patients with bipolar disorder, show findings from the STEP-BD study.

2 Jan 2014

Study finds only small therapeutic effect of CBT on schizophrenic symptoms

Health organisations around the world recommend a form of psychotherapy, known as cognitive-behavioural therapy or CBT, for patients with schizophrenia. Now, however, the most extensive study ever undertaken into its effect on the symptoms of the disorder finds little impact, according to a team of international researchers.

2 Jan 2014

Blood conservation strategy during AVR can reduce costs, complications

Incorporating a blood conservation strategy (BCS) during aortic valve replacement (AVR) can reduce the likelihood of transfusion-related complications, as well as reduce blood-product utilization, according to a study in the January 2014 issue of The Annals of Thoracic Surgery.

2 Jan 2014

TAVI is an effective alternative to AVR for treating aortic stenosis in very elderly patients

Transcatheter aortic valve implantation (TAVI) appears to be an effective alternative to surgical aortic valve replacement (AVR) for the treatment of aortic stenosis in very elderly patients, including those age 85 years and older, according to a study in the January 2014 issue of The Annals of Thoracic Surgery.

2 Jan 2014

Research confirms superior antitumor activity of novel anticancer agent FL118

A team led by Fengzhi Li, PhD, of Roswell Park Cancer Institute has reported significant new findings regarding the chemical structure of the novel anticancer agent FL118. The research, which included comparative analysis of the agent and several similar compounds, confirms the broad, superior antitumor activity of FL118 and suggests promising directions for further studies.

2 Jan 2014

Study reveals potential links to the underlying causes of cancers

New research by scientists at the University of Exeter has shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide - a finding with potential links to the underlying causes of many cancers.

2 Jan 2014

Medical Research News

Molecule produced by brain acts as natural defence mechanism against cannabis

UC Davis docs find a way to create "movies" of wrist in motion using magnetic resonance imaging scans

Scientists discover new class of cells expressing olfactory receptors in human airways

Chinese herbal medicine effective at alleviating acute inflammatory and nerve pain

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Study finds extraordinary link between narcolepsy and specific gene variant

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Macrophages invade diabetic pancreatic tissue during early stages of type 2 diabetes

Computer algorithm developed to identify genes that could be transformed to stop aging process

Overweight children face increased risk of asthma

New research shows that as we age, the thermogenic activity of brown fat gets reduced

Shingles may increase risk of stroke in later life, study finds

Resting-state connectivity and metabolism dissociated in schizophrenia

Family history points to more severe bipolar disorder

Study finds only small therapeutic effect of CBT on schizophrenic symptoms

Blood conservation strategy during AVR can reduce costs, complications

TAVI is an effective alternative to AVR for treating aortic stenosis in very elderly patients

Research confirms superior antitumor activity of novel anticancer agent FL118

Study reveals potential links to the underlying causes of cancers

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