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Researchers compare prescription drug costs between the U.S. and the U.K

The 2009 costs of antibiotics covered by private insurance companies in the U.S. for children younger than 10 years old were estimated to be more than five times higher than the costs in the United Kingdom (U.K.), which are covered by a government universal health plan.

23 Dec 2013

Type 2 diabetes in women less than 45 triples risk of early menopause

Type 2 diabetes - the most common type of diabetes - triples the risk of an early menopause in women younger than 45 years of age, according to new research published in the peer-reviewed journal Climacteric.

23 Dec 2013

TSRI scientists identify compound that shows promise for treating obesity-linked diabetes

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff-it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work.

23 Dec 2013

Researchers start first cancer operation room with navigator

A team of researchers from Gregorio Marañón Hospital, the company GMV and the Universidad Carlos III de Madrid (UC3M) have started the first cancer operation room with a navigator. This image-guided system will allow for increased intraoperative radiotherapy safety.

22 Dec 2013

Melanocyte-secreted fibromodulin promotes angiogenic microenvironment

The decreased vision loss that accompanies age-related macular degeneration (AMD) is associated with abnormal blood vessel growth in the eye. Frequencies of AMD development are different among racial backgrounds, with occurrence of AMD highest among individuals of mixed European decent.

22 Dec 2013

PAZ extracts may be useful option for improving plasma cholesterol profile

Health Enhancement Products, Inc., in conjunction with Wayne State University's Department of Nutrition and Food Science in the College of Liberal Arts and Sciences, announces the publication of a scientific article in the Journal of Nutrition & Metabolism, "ProAlgaZyme sub-fraction improves the lipoprotein profile of hypercholesterolemic hamsters, while inhibiting production of betaine, carnitine, and choline metabolites."

22 Dec 2013

Kessler Foundation scientists awarded subcontract to study ways to improve disability statistics

Kessler Foundation scientists John O'Neill, PhD, CRC and Amanda Botticello, PhD, MPH, were awarded a subcontract on the University of New Hampshire's Rehabilitation Research and Training Center grant on Disability Statistics and Demographics. The five-year grant is funded by the National Institute on Disability and Rehabilitation Research under cooperative agreement H133B130015. Economist Andrew Houtenville, PhD, of UNH's Institute on Disability, is project director of the StatsRRTC grant, which totals $4.3 million.

22 Dec 2013

Small molecule nonsense suppression strategy for aniridia-associated defects

Congenital aniridia is a progressive disease that is associated with improper development of eye structures as well as abnormalities in the brain and pancreas. A variety of nonsense mutations in the PAX6 gene are linked with aniridia; however, despite understanding the genetic basis of the disease, few treatment and prevention strategies are available.

22 Dec 2013

Study: High levels of depressive symptoms may be associated with delayed ART initiation

Researchers from Boston University's School of Medicine and College of Arts and Sciences found that among HIV-infected Russian drinkers, depressive symptom severity alone was not significantly associated with lower rates of antiretroviral therapy initiation. However, when examining cognitive symptoms of depression, results showed that high levels of depressive symptoms may be associated with delayed ART initiation.

22 Dec 2013

Study supports use of two drugs for treating children with aggression and disruptive behavior

Prescribing both a stimulant and an antipsychotic drug to children with physical aggression and attention-deficit/hyperactivity disorder, along with teaching parents to use behavior management techniques, reduces aggressive and serious behavioral problems in the children, according to a study conducted by researchers at The Ohio State University Wexner Medical Center.

22 Dec 2013

Research finding could lead to development of vaccine and therapies for mucormycosis

Mucormycosis is a deadly infection that strikes people with weakened immune systems when certain types of fungi, called Mucorales, invade the patients' cells. A novel protein on the surface of the Mucorales cells, called CotH, makes this invasion possible.

22 Dec 2013

Researchers evaluate mangafodipir for relief of oxaliplatin-associated neuropathies

An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must be balanced with prevention of neuropathies. Currently, there are no therapeutic interventions available to relieve oxaliplatin-associated neurological symptoms, which are thought to be a result of reactive oxygen species-associated damage.

22 Dec 2013

Patients with Loeys-Dietz syndrome at increased risk for aortic aneurysm

Patients with the connective tissue disorder Loeys-Dietz syndrome are at high risk for aortic aneurysm. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF-β. LDS-associated mutations are predicted to reduce TGF-β signaling; however, aortic tissue samples from LDS patients indicate that TGF-β signaling may be enhanced.

22 Dec 2013

Studies yield new insights into molecular mechanisms that underlie learning process

Learning requires constant reconfiguration of the connections between nerve cells. Two new studies now yield new insights into the molecular mechanisms that underlie the learning process.

22 Dec 2013

Manipulating epigenetic mechanism may promote cell death in pediatric brain cancer

Researchers at the Federal University of Rio Grande do Sul, the university hospital (Hospital de Cl-nicas de Porto Alegre, HCPA) and the Children's Cancer Institute (Instituto do C-ncer Infantil do Rio Grande do Sul, ICI-RS) in Porto Alegre, Brazil, have shown that manipulating an epigenetic mechanism, which regulates gene expression, may promote cell death and favor maturation towards less malignant-prone phenotypes in pediatric brain cancer cell lines.

22 Dec 2013

Engineered immune cells show antitumor activity in two patients with advanced cancers

Engineered immune cells, called CARTmeso cells, designed to direct antitumor immune responses toward tumors that carry a protein called mesothelin, showed antitumor activity in two patients with advanced cancers that had not responded to prior treatments, according to a study published in Cancer Immunology Research, a journal of the American Association for Cancer Research.

22 Dec 2013

New optical device puts the power to detect retinal disease in the palm of a hand

A new optical device puts the power to detect eye disease in the palm of a hand. The tool-about the size of a hand-held video camera-scans a patient's entire retina in seconds and could aid primary care physicians in the early detection of a host of retinal diseases including diabetic retinopathy, glaucoma and macular degeneration.

22 Dec 2013

Monthly pharmacist appointments help patients solve medication-related problems

Patients are more likely to take chronic medications when they meet monthly with pharmacists to coordinate medication schedules and treatments, according to a Virginia Commonwealth University study.

22 Dec 2013

Six common diseases arise from DNA changes, finds new research

Many rare disorders are caused by gene mutation, like sickle cell anemia. Yet until now the underlying genetic cause of more common conditions - for example, rheumatoid arthritis - has evaded scientists for years.

22 Dec 2013

International researchers study glycans that could help clinicians diagnose gastric cancer early

Gastric cancer kills more than 700,000 people each year, mostly in Latin America, Asia and Eastern Europe. Though the disease is quite treatable when caught early, symptoms are indistinct and late detection leads to high mortality. The five-year survival rate in the United States is 26.9 percent.

22 Dec 2013

Medical Research News

Researchers compare prescription drug costs between the U.S. and the U.K

Type 2 diabetes in women less than 45 triples risk of early menopause

TSRI scientists identify compound that shows promise for treating obesity-linked diabetes

Researchers start first cancer operation room with navigator

Melanocyte-secreted fibromodulin promotes angiogenic microenvironment

PAZ extracts may be useful option for improving plasma cholesterol profile

Kessler Foundation scientists awarded subcontract to study ways to improve disability statistics

Small molecule nonsense suppression strategy for aniridia-associated defects

Study: High levels of depressive symptoms may be associated with delayed ART initiation

Study supports use of two drugs for treating children with aggression and disruptive behavior

Research finding could lead to development of vaccine and therapies for mucormycosis

Researchers evaluate mangafodipir for relief of oxaliplatin-associated neuropathies

Patients with Loeys-Dietz syndrome at increased risk for aortic aneurysm

Studies yield new insights into molecular mechanisms that underlie learning process

Manipulating epigenetic mechanism may promote cell death in pediatric brain cancer

Engineered immune cells show antitumor activity in two patients with advanced cancers

New optical device puts the power to detect retinal disease in the palm of a hand

Monthly pharmacist appointments help patients solve medication-related problems

Six common diseases arise from DNA changes, finds new research

International researchers study glycans that could help clinicians diagnose gastric cancer early

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