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Scientists find inhibiting action of BRD4 protein may eradicate rare type of soft-tissue cancer

A deadly, rare type of soft-tissue cancer may be completely eradicated simply by inhibiting a key protein involved in its growth, UT Southwestern Medical Center researchers report.

27 Dec 2013

Concussion involving momentary loss of consciousness may be related to buildup of Alzheimer's

A new study suggests that a history of concussion involving at least a momentary loss of consciousness may be related to the buildup of Alzheimer's-associated plaques in the brain.

27 Dec 2013

Magnetic nanoparticles-based method uses saliva to screen DNA polymorphism in stroke patients

C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is a risk factor for stroke. Studies have report a higher C677T homozygosity frequency in Chinese than in Europeans. Usually, the detection of genetic diseases is rather complicated on a large scale owing to the invasive sampling and a cumbersome DNA extraction process.

27 Dec 2013

Surgery offers better survival, functional outcomes than chemotherapy for patients with tongue cancer

Patients with tongue cancer who started their treatment with a course of chemotherapy fared significantly worse than patients who received surgery first, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

27 Dec 2013

THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells-macrophages-are stimulated in response to pathogens.

27 Dec 2013

Activation of protein P300 plays central role in DNA repair in hippocampal neurons

Various medications have been developed to treat neurodegenerative disorders, and drugs without significant side effects are gaining widespread interest such disorders.

27 Dec 2013

Transient receptor potential channel A1 causes calcitonin gene-related peptide release in neurons

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperalgesia.

26 Dec 2013

Researchers uncover new genetic clue that contributes to increased risk of type 2 diabetes

An international team of researchers in Mexico and the United States has uncovered a new genetic clue that contributes to an increased risk of developing type 2 diabetes, particularly the elevated risk among Mexican and other Latin American populations.

26 Dec 2013

CAC screening plays more prominent role in determining risk for heart attack and stroke

A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person’s risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery.

26 Dec 2013

Researchers complete genomic analysis of cervical cancer in two patient populations

Researchers from the Boston area, Mexico, and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.

25 Dec 2013

Younger women with breast cancer less likely to receive radiotherapy after BCS

Radiotherapy after breast conserving surgery has been shown to reduce the risk of breast cancer recurrence. However, although younger women tend to have more aggressive tumors and have higher risks of recurrence than older BC patients, they are less likely to receive RT after BCS, according to a study published December 24 in the Journal of the National Cancer Institute. Although treatment patterns among older BC patients have been well-studied, factors affecting non-compliance among younger women are not well-known.

25 Dec 2013

Cognitive behavioral therapy reduces headache frequency, migraine-related disability in children

Among children and adolescents with chronic migraine, the use of cognitive behavioral therapy resulted in greater reductions in headache frequency and migraine-related disability compared with headache education, according to a study appearing in the December 25 issue of JAMA.

25 Dec 2013

On-site testing for HIV, STIs declines substantially between 2000 and 2011: Study

A survey of opioid treatment programs finds that the proportion offering on-site testing for human immunodeficiency virus and sexually transmitted infections declined substantially between 2000 and 2011, despite guidelines recommending routine opt-out HIV testing in all health care settings, according to a study appearing in the December 25 issue of JAMA.

25 Dec 2013

Antidepressant nortriptyline does not improve overall symptoms in patients with idiopathic gastroparesis

Among patients with idiopathic (of unknown cause) gastroparesis, use of the antidepressant nortriptyline compared with placebo for 15 weeks did not result in improvement in overall symptoms, according to a study appearing in the December 25 issue of JAMA.

25 Dec 2013

Diflunisal drug reduces neurological decline in patients with familial transthyretin amyloidosis

A recent study led by researchers from the Amyloidosis Center at Boston University School of Medicine and Boston Medical Center demonstrates that diflunisal, a generic anti-inflammatory drug, successfully reduced neurological decline and preserved the quality of life in patients with familial transthyretin amyloidosis. Diflunisal is an inexpensive and safe medication marketed over the past 40 years for arthritis and pain.

25 Dec 2013

Prolonged exposure therapy shows greater success for treating adolescent PTSD patients

Researchers at Penn Medicine report in the December 25 issue of JAMA that a modified form of prolonged exposure therapy - in which patients revisit and recount aloud their trauma-related thoughts, feelings and situations - shows greater success than supportive counseling for treating adolescent PTSD patients who have been sexually abused.

25 Dec 2013

Research shows that human brains stumble on even the simplest rule-based calculations

Even scientists are fond of thinking of the human brain as a computer, following sets of rules to communicate, make decisions and find a meal.

24 Dec 2013

Chinese experts publish consensus on spine and spinal cord injury

The early management of acute thoracolumbar spine and spinal cord injury is one of the most difficult tasks when treating trauma cases. To standardize the evaluation and treatment of acute thoracolumbar spinal injury, the Chinese Association of Spine and Spinal Cord Injury organized a group of Chinese experts to collectively discuss the draft of "An Expert Consensus on the Evaluation and Treatment of Acute Thoracolumbar Spine and Spinal Cord Injury".

24 Dec 2013

Hypoxic preconditioning has protective effects against acute cerebral infarction

Hypoxic preconditioning has been shown to have protective effects against acute cerebral infarction. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, Prof. Xunming Ji and team from Xuanwu Hospital, Capital Medical University in China induced a photochemical model of cerebral infarction in an inbred line of mice (BALB/c) which were exposed to hypoxic preconditioning prior to model establishment.

24 Dec 2013

Study: Antidepressants not effective for bipolar disorder treatment

The use of antidepressants in the treatment of bipolar disorder remains controversial. Some studies and treatment guidelines suggest that antidepressant treatment for bipolar disorder may have the potential to increase the manic switch, while others recommend short-term antidepressant treatment and early discontinuation.

24 Dec 2013

Medical Research News

Scientists find inhibiting action of BRD4 protein may eradicate rare type of soft-tissue cancer

Concussion involving momentary loss of consciousness may be related to buildup of Alzheimer's

Magnetic nanoparticles-based method uses saliva to screen DNA polymorphism in stroke patients

Surgery offers better survival, functional outcomes than chemotherapy for patients with tongue cancer

THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

Activation of protein P300 plays central role in DNA repair in hippocampal neurons

Transient receptor potential channel A1 causes calcitonin gene-related peptide release in neurons

Researchers uncover new genetic clue that contributes to increased risk of type 2 diabetes

CAC screening plays more prominent role in determining risk for heart attack and stroke

Researchers complete genomic analysis of cervical cancer in two patient populations

Younger women with breast cancer less likely to receive radiotherapy after BCS

Cognitive behavioral therapy reduces headache frequency, migraine-related disability in children

On-site testing for HIV, STIs declines substantially between 2000 and 2011: Study

Antidepressant nortriptyline does not improve overall symptoms in patients with idiopathic gastroparesis

Diflunisal drug reduces neurological decline in patients with familial transthyretin amyloidosis

Prolonged exposure therapy shows greater success for treating adolescent PTSD patients

Research shows that human brains stumble on even the simplest rule-based calculations

Chinese experts publish consensus on spine and spinal cord injury

Hypoxic preconditioning has protective effects against acute cerebral infarction

Study: Antidepressants not effective for bipolar disorder treatment

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