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Scientists identify new targets to develop treatment for HD

Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease. These enzymes, matrix metalloproteinases, provide new targets for drug therapies for the disease - targets that have already been shown to respond to cancer drugs currently in clinical development.

29 Jul 2010

Genetic signals determine neurotransmitter use for communication

Cascades of genetic signals determine which neurotransmitter a brain cell will ultimately use to communicate with other cells. Now a pair of reports from biologists at the University of California, San Diego, have shown for the first time that electrical activity in these developing neurons can alter their chemical fate-and change an animal's behavior-by tweaking this genetic program.

29 Jul 2010

Study reveals high rate of atrial fibrillation in patients with early stages of CKD

Millions of Americans in the early stages of chronic kidney disease (CKD) are at an increased risk of having atrial fibrillation (AF) - a major risk factor for stroke - according to new research by investigators at Wake Forest University Baptist Medical Center.

29 Jul 2010

REM sleep behavior disorder may later lead to neurologic disorders

A new study shows that a sleep disorder may be a sign of dementia or Parkinson's disease up to 50 years before the disorders are diagnosed. The research is published in the July 28, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology.

29 Jul 2010

Loss of key nerve cells cause Parkinson's disease: Research

Scientists at the Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. This discovery not only may explain how a genetic mutation linked to Parkinson's causes the cells' death, but could also open the door to new therapeutic approaches for the malady.

29 Jul 2010

Scientists study mutant protein lump formation process to control brain cell death

Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals.

29 Jul 2010

Increased SIRT1 protein can delay delay aging, extend lifespan

Researchers watched two groups of mice, both nearing the end of a two-day fast. One group was quietly huddled together, but the other group was active and alert. The difference? The second set of mice had been engineered so their brains produced more SIRT1, a protein known to play a role in aging and longevity.

29 Jul 2010

Inhibition of MMPs can offer therapeutic benefit in Huntington's disease: Study

A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for this devastating incurable disease.

29 Jul 2010

Aggressive prostate cancer patients tend to retain denser bones

Men who develop prostate cancer, especially the more aggressive and dangerous forms that spread throughout the body, tend to retain denser bones as they age than men who stay free of the disease, suggests new research from Johns Hopkins and the National Institute on Aging (NIA), part of the National Institutes of Health.

29 Jul 2010

Scientists identify new catalytic process to create pharmaceuticals with less chemical waste

Much like two children in the back seat of a car, it can be challenging to get two catalysts to cooperate for the greater good. Now Northwestern University chemists have gotten two catalysts to work together on the same task -- something easily done by nature but a difficult thing to do in the laboratory.The findings, published by the journal Nature Chemistry, will allow medicinal chemists to invent new reactions and produce valuable bioactive compounds faster with less impact on the environment.

29 Jul 2010

HIV drug can raise the risk of heart disease: Study

There are a handful of drugs effective in treating HIV/AIDS. However new research shows that some of these drugs can increase the risk of heart attacks. The results come from a Garvan Institute of Medical Research study involving 20 people, 10 taking the drug Ritonavir and 10 others the drug Raltegravir for one month.

28 Jul 2010

SCCT names recipients of fourth annual Young Investigator Award

The Society of Cardiovascular Computed Tomography (SCCT), the leading international professional society dedicated to research, education and clinical excellence in cardiovascular computed tomography (CT), has named Dr. Raman Dusaj and Dr. Thomas Smith the recipients of the fourth annual Young Investigator Award. The Young Investigator Award was announced at SCCT's 2010 Annual Scientific Meeting in Las Vegas.

28 Jul 2010

Study of over 6,200 impairment ratings spanning 5 years reveals 78% error rate

A study of more than 6,200 impairment ratings spanning 5 years revealed an error rate of 78 percent, resulting in ratings averaging more than twice what was appropriate. Ratings from eight states were examined, with 81 percent of the cases being from California and 91% rated using the Fifth Edition of the American Medical Association Guides to the Evaluation of Permanent Impairment.

28 Jul 2010

POA releases consensus statement on CIRS-WDB

Policyholders of America released a consensus statement written by treating physicians and researchers in the field on the mechanism and treatment of illness found in people sickened by exposure to water-damaged buildings. This illness has been the subject of heated debate that has resulted in harsh allegations being lobbed at patients by experts hired by industry to cast doubt on the legitimacy of the illness.

28 Jul 2010

Studies reveal impact and spread of CVBDs worldwide

Fascinating studies giving new insights into the spread of leishmaniosis in the UK and France, the appearance of new CVBDs in Germany, the state of heartworm infection in Korea and the neurological impact on humans of long-term bartonella infection from the USA are among the papers now available for download from http://www.cvbd.org, as the proceedings of the 5th Annual Canine Vector Borne Disease (CVBD) World Forum are made available online today.

28 Jul 2010

Students with ADHD less likely to finish high school graduation: Study

Teens with attention-deficit/hyperactivity disorder - the most common childhood psychiatric condition in the United States - are less likely to finish high school on time than students with other mental-health disorders that often are considered more serious, a large national study by researchers at the UC Davis School of Medicine has found. The study found that nearly one third of students with ADHD, twice the proportion as students with no psychiatric disorder, either drop out or delay high school graduation.

28 Jul 2010

Astellas extends non-exclusive license agreement with Regeneron for VelocImmune technology

Regeneron Pharmaceuticals, Inc. and Astellas Pharma Inc. announced that Astellas has extended through 2023 the non-exclusive license agreement that allows Astellas to utilize Regeneron's VelocImmune® technology in its internal research programs to discover fully human monoclonal antibody product candidates.

28 Jul 2010

Research presents theoretical model that predicts HFE values of organic compounds

Drug delivery inside the body is a complicated process. Compounds travel through a maze of aqueous solutions, lipid membranes, and barriers between the blood and tissues like the brain. Research reported in the American Institute of Physics publication the Journal of Chemical Physics presents a theoretical model that accurately predicts the hydration free energy of a wide variety of organic compounds.

28 Jul 2010

New study on treating CP with HBOT is making waves in India, U.S.

A new study on treating Cerebral Palsy with Hyperbaric Oxygen Therapy is making waves in India and the U.S. The largest sample of children studied to assess neuro-developmental improvements focuses on a combination of standard rehabilitation therapies, such as Occupational, Physical, Speech Therapies and HBOT.

28 Jul 2010

Researchers examine risk of serious complications associated with bariatric procedure

An examination of hospital complication rates of bariatric surgery for more than 15,000 patients in Michigan finds that the frequency of serious complications is relatively low and is inversely associated with hospital and surgeon procedural volume, according to a study in the July 28 issue of JAMA.

28 Jul 2010