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Human embryonic stem cells derived from preimplantation genetically diagnosed embryos

A human stem cell line derived from embryos that were identified by preimplantation genetic diagnosis (PGD) to carry the mutation for fragile X syndrome has provided an unprecedented view of early events associated with this disease.

15 Nov 2007

Hormone orexin links sleep, hunger and metabolism

While investigating how the hormone orexin might control sleep and hunger, researchers at UT Southwestern Medical Center have discovered, to their surprise, that it activates a protein, HIF-1, long known to stimulate cancerous tumor growth.

15 Nov 2007

Freeze-dried grape powder blocks genes linked to colon cancer

Low doses of freeze-dried grape powder inhibit genes linked to the development of sporadic colorectal cancer, University of California, Irvine cancer researchers found.

15 Nov 2007

Research confirms the importance of genetic factors in age-associated hearing loss

A new Brandeis University study of twins shows that genes play a significant role in the level of hearing loss that often appears in late middle age. The research, in the Journal of Gerontology Medical Sciences, examined genetic and environmental factors affecting hearing loss in the frequency range of speech recognition.

15 Nov 2007

Medics worry about ethnic sensitivity

Health professionals worry that a lack of knowledge about different cultures may lead to them being seen as insensitive or inappropriate to patients from different ethnic backgrounds - according to research published today.

14 Nov 2007

Understanding diversity in disease - new routes to prevention, diagnosis and treatment

The Medical Research Council (MRC), the National Institute for Health Research (NIHR) and the health research departments in Northern Ireland, Scotland and Wales have launched a joint initiative of more than £6millon to identify small carefully defined groups of patients to help researchers detect, treat or prevent diseases.

14 Nov 2007

Low-fat answer to India's coronary crisis

First he devised a way for India's 11 million dairy farmers to improve milk production. Now Dr Suresh Gulati of the University of Sydney's Faculty of Veterinary Science is making milk healthier in a country where coronary heart disease is set to soar.

14 Nov 2007

Gene variants behind pancreatic stone formation

Stone formation is an important feature of chronic pancreatitis, especially tropical calcific pancreatitis (TCP), where the stones are large in size, highly irregular in shape and cause enormous tissue destruction.

14 Nov 2007

Telomerase enzyme structure provides significant new target for anti-cancer therapies

Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Since the mid-1990s, when telomerase was first identified in human tumors, scientists have eyed the enzyme as an ideal target for developing broadly effective anti-cancer drugs.

14 Nov 2007

Hope on the horizon for hereditary angioedema sufferers

Although there is currently no treatment approved by the Federal Drug Administration (FDA) for acute attacks of hereditary angioedema (HAE) - a genetic disease causing swelling of extremities, face and internal organs that can be life-threatening - hope is on the horizon according to a team of experts presenting the latest research at the Annual Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Dallas.

14 Nov 2007

New insight into ulcerative colitis

Social, environmental and dietary changes are associated with the changes of disease spectrum in a country. Ulcerative colitis has become a commonly seen disease in China, probably due to extensive consumption of Western foods in recent years.

14 Nov 2007

Tumor-suppressor gene for lung cancer identified

The GPRC5A gene, which is under-expressed in human lung cancer cells, suppresses lung tumors in mouse models and could provide a key to attacking lung cancer in humans, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 21 edition of The Journal of the National Cancer Institute.

14 Nov 2007

Higher-risk kidneys may help solve organ shortage facing older adults

New research from Wake Forest University Baptist Medical Center suggests that age alone shouldn't be a barrier to receiving a kidney transplant – and that using donated kidneys that would once have been discarded may help alleviate the burgeoning organ shortage among older adults.

14 Nov 2007

Real-time 3-D analysis of breast cancer biopsies

A sophisticated microscope that offers a “real-time” 3-D analysis of tissue samples might, in the future, reduce the number of needle biopsies traditionally needed from women suspected of having breast cancer, according to recent research published at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center.

14 Nov 2007

Neurofibromatosis 1 gene drives pivotal decision in early brain development

A gene linked to pediatric brain tumors is an essential driver of early brain development, researchers at Washington University School of Medicine in St. Louis have found.

14 Nov 2007

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration

Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.

14 Nov 2007

New method for early diagnosis of pulmonary hypertension

Researchers at the University of Granada ( UGR ) from the Systemic Autoimmune Diseases Unit and the Cardiology Service of the Hospital Clínico San Cecilio in Granada have developed an innovative system which will help doctors make the earliest diagnosis of pulmonary hypertension possible, which is the main cause of death for patients suffering from scleroderma, a rare disease which affects approximately 1,200 out of every million people.

14 Nov 2007

ADHD a result of delayed brain development

Scientists in the United States have discovered that youngsters with attention deficit hyperactivity disorder (ADHD) have a delay in the development of some parts of their brains.

13 Nov 2007

Zinc transporters regulate pancreatic cancer

Zinc, an important trace element for healthy growth and development, can be related to pancreatic cancer. Too much ZIP4, a molecule that enables the transport of zinc into cells, promotes the growth and spread of pancreatic tumors cells, said a group of researchers from Baylor College of Medicine in Houston, The University of Texas M.D. Anderson Cancer Center and the University of Florida in Gainesville, in a report which appears online today in the Proceedings of the National Academy of Sciences.

13 Nov 2007

Placenta uses a cloaking device similar to that used by parasites

The placenta uses a cloaking device similar to that used by parasites to avoid detection by the mother's immune system. MRC funded scientists looking to develop a diagnostic test for pre-eclampsia, a major and potentially fatal cause of fetal and maternal illness, made the amazing discovery which could have far reaching implications.

13 Nov 2007