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The key to unlocking the secret of highly specific DNAzyme catalysis

Using an extremely sensitive measurement technique, researchers at the University of Illinois have found clear evidence that a lead-specific DNAzyme uses the "lock and key" reaction mechanism.

13 Nov 2007

Researchers image a biomarker of neurogenesis

Mirjana Maletic-Savatic, M.D., Ph.D, and co-investigators from Stony Brook University Medical Center, Brookhaven National Laboratory and Cold Spring Harbor Laboratory have discovered a way to image a biomarker of neural stem and progenitor cells (NPCs) in the living human brain.

13 Nov 2007

New therapies to switch genes on and off

A new study led by researchers at the University of Southern California (USC) identifies how genes are silenced in cancer cells through distinct changes in the density of nucleosomes within the cells.

13 Nov 2007

Research looks at how environment inside a living cell affects protein structure

The syrupy soup of proteins, ribosomes and membranes inside a living cell is so tightly packed it may increase the structural content of proteins by as much as 25 percent, according to new research from Rice University and the University of Houston (UH).

13 Nov 2007

New insights into cataracts

Using the tools and techniques of soft condensed matter physics, a research team in Switzerland has demonstrated that a finely tuned balance of attractions between proteins keeps the lens of the eye transparent, and that even a small change in this balance can cause proteins to aggregate and de-mix.

13 Nov 2007

Overexpression of neuroglobin reduces severity of Alzheimer's disease in mice

Mice genetically engineered to both overproduce the protein neuroglobin and to develop Alzheimer's disease (AD) had a much milder form of the disease when compared to mice engineered to have AD alone, researchers at the Buck Institute for Age Research have reported.

13 Nov 2007

Tiny fluorescent probes illuminate protein interactions in living cells

While fluorescence has long been used to tag biological molecules, a new technology developed at Yale allows researchers to use tiny fluorescent probes to rapidly detect and identify protein interactions within living cells while avoiding the biological disruption of existing methods, according to a report in Nature Chemical Biology.

13 Nov 2007

New target for MS treatment found using old drug

A drug currently used to treat high blood pressure and heart failure has been found to reduce the symptoms of multiple sclerosis in mice.

13 Nov 2007

Mycophenolate mofetil therapy effective for reducing lupus flares

Mayo Clinic researchers have shown that an immunosuppressive drug used in organ transplant cases is effective in reducing flare-ups in patients with systemic lupus erythematosus (SLE)

13 Nov 2007

Brain may have important influences on glucose metabolism and insulin action

An appetite-suppressing chemical also improves glucose tolerance and lowers insulin levels in obese and diabetic mice, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

13 Nov 2007

Life-threatening gene defect related to thoracic aortic disease discovered

A research team led by scientists at The University of Texas Medical School at Houston has identified a defective gene that affects vascular smooth-muscle cells in people who suffer from hereditary thoracic aortic disease, which can kill victims with little warning in the prime of their lives.

13 Nov 2007

Discovery of key pathway, potential drug targets in autoinflammatory disease

Molecular biologists at Jefferson's Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases.

13 Nov 2007

Anti-inflammation molecule helps fight MS-like disease

An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis (MS). Neurology researchers led by Abdolmohamad Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia, have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease.

13 Nov 2007

Factor key to severity of community-associated methicillin-resistant staph infections identified

Newly described proteins in drug-resistant strains of the Staphylococcus aureus bacterium attract and then destroy protective human white blood cells - a key process ensuring that S. aureus survives and causes severe disease, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

13 Nov 2007

Diet rich in leafy vegetables may minimize damage caused by heart attacks

A diet rich in leafy vegetables may minimize the tissue damage caused by heart attacks, according to researchers at the Albert Einstein College of Medicine of Yeshiva University.

13 Nov 2007

New genetic schizophrenia link found

Schizophrenia is a debilitating psychiatric illness. Its cause is currently poorly understood, and there is no known cure.

13 Nov 2007

Holiday sex common place in young Britons

Around one in five young Britons has sex with a new partner while overseas, finds research published ahead of print in the journal Sexually Transmitted Infections.

13 Nov 2007

Turmeric back in the fight against cancer

Scientists have known for some time that turmeric, a key flavour in Indian curry, has anti-cancer properties.

7 Nov 2007

High fat diets throw body clock out of sync

The researchers from the Northwestern University and Evanston Northwestern Healthcare in Illinois, suggest that overeating alters the core mechanism of the body clock and disrupts the timing of internal signals such as appetite control.

7 Nov 2007

Molecular docking unlocks function of enzymes

Fitting a key into a lock may seem like a simple task, but researchers at Texas A&M University are using a method that involves testing thousands of keys to unlock the functions of enzymes, and their findings could open the door for new targets for drug designs.

6 Nov 2007