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Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

The brain contains about 100 million nerve cells, each having 10,000 connections to other nerves cells. These connections, called synapses, chemically transmit the information that controls all brain function via proteins called receptors. These processes are believed to be the basis of learning and memory.

7 May 2007

Hypertension drugs offer a double whammy

Researchers at the Wake Forest University School of Medicine in the U.S. suggest that some medications taken for high blood pressure may have other uses.

7 May 2007

New vitamin extends lifespan in yeast cells

Imagine taking a vitamin for longevity! Not yet, but a Dartmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step closer.

4 May 2007

Vigorous active lifestyle keeps people thin with age

The old adage "use it or lose it" is truer than ever. People who maintain a vigorously active lifestyle as they age gain less weight than people who exercise at more moderate levels, according to a first-of-its-kind study that tracked a large group of runners who kept the same exercise regimen as they grew older.

4 May 2007

Reducing levels of the protein tau can prevent seizures and neurological deficits related to Alzheimer's disease

The findings, reported in the journal Science, demonstrate that when tau is removed from mice genetically engineered to simulate Alzheimer's disease, their memory function is retained and they live a normal lifespan. Reducing tau levels also made mice more resistant to epileptic seizures.

4 May 2007

New understanding of genetic mutation that contributes to autism

The investigators now know more about how the mutation causes problems with a specific gene and are testing for additional mutations of the same gene in other people with autism.

4 May 2007

Nitric oxide may be the key to why specific drugs for heart failure or asthma lose their effectiveness over time

A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time.

4 May 2007

Research paves the way for new therapies designed to manage heart disease in older population

Ischaemic heart disease, characterised by reduced blood flow to the heart, is Australia's and the world's leading cause of death.

4 May 2007

Nutrient "floodgate" protects against inflammatory immune response

After every meal, the body must prevent the immune system from launching an all-out fight against food.

4 May 2007

Renewal of Echinacea and St John's Wort research

A five-year-old research center dedicated to understanding and improving Echinacea and Hypericum perforatum (St. John's wort) has received $4.4 million in continuation funding from the National Institutes of Health. The renewal is for three years.

4 May 2007

Treating ticks with antibiotics inhibits their reproduction

Bacteria that may provide ticks with essential nutrients they can't get from their meals of blood could be a key to controlling ticks and the diseases they carry, a new study published in the PLoS ONE shows.

4 May 2007

Men and women at risk for alcohol dependence are more likely to choose a mate who also is at risk

Alcoholism is more common among partners of alcoholics than among partners of non-alcoholics, but it isn't as common as it might be. The researchers found that in some cases, one spouse's excesses with alcohol actually could help protect the other from alcohol dependence.

4 May 2007

Single gene is responsible for most cool temperature sensation

The discovery, reported in the May 3 issue of the journal Neuron, might one day lead to the development of drugs that induce cold sensation as an analgesic, or block it to prevent certain forms of chronic pain associated with cold sensation.

4 May 2007

Prenatal toxicity linked to immune dysfunctions in later life

A Cornell researcher and his wife have conducted the first comprehensive review of later-life diseases that develop in people who were exposed to environmental toxins or drugs either in the womb or as infants.

4 May 2007

Machine preservation may promote more organ sharing

Preserving the kidneys of deceased older donors on a pump, as opposed to the conventional method of storing and transporting organs in a cooler, may lower hospital costs, improve initial organ function, and promote greater use and more sharing of organs, according to new research by Wake Forest University Baptist Medical Center.

4 May 2007

Scientists discover molecular mechanism that keeps HSV-1 activation restricted to a single gene for months or even years

By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1.

4 May 2007

Backup brain region compensates for stroke

Researchers have pinpointed in humans how a "backup" brain region springs into action to compensate for disruption of a primary functional area, as happens during stroke.

4 May 2007

Gene malfunctions cause schizophrenia, depression symptoms in mice

Researchers have demonstrated for the first time that malfunction of a gene that had been associated with schizophrenia and depression does indeed cause symptoms of those disorders.

4 May 2007

Women from all ethnic backgrounds are more successful at passing UK medical exams than their male counterparts

Women from all ethnic backgrounds are more successful at passing UK medical exams than their male counterparts, according to research published in the open access journal BMC Medicine.

4 May 2007

New way to target and potentially treat tumors

Research teams at Yale University and the University of Rhode Island have demonstrated a new way to target and potentially treat tumors using a short piece of protein that acts like a nanosyringe to deliver tags or therapy to cells, according to a report in the Proceedings of the National Academy of Sciences.

2 May 2007