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Diabetes drug rosiglitazone boosts power of platinum chemotherapy

A widely used diabetes drug dramatically boosted the potency of platinum-based cancer drugs when administered together to a variety of cancer cell lines and to mice with tumors, scientists from Dana-Farber Cancer Institute report.

8 May 2007

Brain cells 'talk' with each other in more ways than previously thought

Johns Hopkins scientists have discovered to their surprise that nerves in the mammalian brain's white matter do more than just ferry information between different brain regions, but in fact process information the way gray matter cells do.

8 May 2007

Loss of a single gene in kidney cancer cells causes them to stop making mitochondria

Studying a rare inherited syndrome, researchers at Johns Hopkins have found that cancer cells can reprogram themselves to turn down their own energy-making machinery and use less oxygen, and that these changes might help cancer cells survive and spread.

8 May 2007

Antidepressants induce new nerve cell growth in the hippocampus

The growth of new nerve cells in the hippocampus has been suggested as the way antidepressants work in rodents, says Eric Nestler, MD, PhD, of the University of Texas Southwestern Medical Center.

8 May 2007

How inhaled anthrax paralyzes the body's defenses

University of Florida researchers have revealed how the inhaled form of anthrax paralyzes the body's defenses and prevents immune cells from reaching the site of infection.

8 May 2007

Cut down on salt to cut down your high blood pressure

Researchers in Canada say if every Canadian cut their salt intake in half high blood pressure would be eliminated in one million people.

8 May 2007

Molecule that destroys bone also protects it

An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.

7 May 2007

Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

The brain contains about 100 million nerve cells, each having 10,000 connections to other nerves cells. These connections, called synapses, chemically transmit the information that controls all brain function via proteins called receptors. These processes are believed to be the basis of learning and memory.

7 May 2007

Hypertension drugs offer a double whammy

Researchers at the Wake Forest University School of Medicine in the U.S. suggest that some medications taken for high blood pressure may have other uses.

7 May 2007

New vitamin extends lifespan in yeast cells

Imagine taking a vitamin for longevity! Not yet, but a Dartmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step closer.

4 May 2007

Vigorous active lifestyle keeps people thin with age

The old adage "use it or lose it" is truer than ever. People who maintain a vigorously active lifestyle as they age gain less weight than people who exercise at more moderate levels, according to a first-of-its-kind study that tracked a large group of runners who kept the same exercise regimen as they grew older.

4 May 2007

Reducing levels of the protein tau can prevent seizures and neurological deficits related to Alzheimer's disease

The findings, reported in the journal Science, demonstrate that when tau is removed from mice genetically engineered to simulate Alzheimer's disease, their memory function is retained and they live a normal lifespan. Reducing tau levels also made mice more resistant to epileptic seizures.

4 May 2007

New understanding of genetic mutation that contributes to autism

The investigators now know more about how the mutation causes problems with a specific gene and are testing for additional mutations of the same gene in other people with autism.

4 May 2007

Nitric oxide may be the key to why specific drugs for heart failure or asthma lose their effectiveness over time

A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time.

4 May 2007

Research paves the way for new therapies designed to manage heart disease in older population

Ischaemic heart disease, characterised by reduced blood flow to the heart, is Australia's and the world's leading cause of death.

4 May 2007

Nutrient "floodgate" protects against inflammatory immune response

After every meal, the body must prevent the immune system from launching an all-out fight against food.

4 May 2007

Renewal of Echinacea and St John's Wort research

A five-year-old research center dedicated to understanding and improving Echinacea and Hypericum perforatum (St. John's wort) has received $4.4 million in continuation funding from the National Institutes of Health. The renewal is for three years.

4 May 2007

Treating ticks with antibiotics inhibits their reproduction

Bacteria that may provide ticks with essential nutrients they can't get from their meals of blood could be a key to controlling ticks and the diseases they carry, a new study published in the PLoS ONE shows.

4 May 2007

Men and women at risk for alcohol dependence are more likely to choose a mate who also is at risk

Alcoholism is more common among partners of alcoholics than among partners of non-alcoholics, but it isn't as common as it might be. The researchers found that in some cases, one spouse's excesses with alcohol actually could help protect the other from alcohol dependence.

4 May 2007

Single gene is responsible for most cool temperature sensation

The discovery, reported in the May 3 issue of the journal Neuron, might one day lead to the development of drugs that induce cold sensation as an analgesic, or block it to prevent certain forms of chronic pain associated with cold sensation.

4 May 2007