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Can music therapy be the breakthrough dementia care desperately needs?

Music therapy reduces distress and improves well-being in advanced dementia by meeting unmet needs, enhancing caregiver-patient understanding, and fostering humanizing connections in institutional care settings.

18 Nov 2024

Spermidine regulates RIPK1 to combat diabetes and vascular damage

Researchers reveal that spermidine-mediated acetylhypusination of RIPK1 suppresses necroptosis and insulin resistance, offering potential therapeutic strategies for type 2 diabetes.

18 Nov 2024

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Engineered SNIPRs transform CAR T-cell precision for safer cancer therapy

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR T-cells. This breakthrough enhances tumor targeting while reducing off-target effects, paving the way for advanced synthetic biology applications.

17 Nov 2024

Growth hormone-releasing hormone transforms therapeutic potential in health and chronic disease

Researchers review the biological activities of growth hormone-releasing hormone and its analogs.

17 Nov 2024

Engineered virus-like particles evolve for superior gene delivery efficiency

Researchers developed a barcoded directed evolution system for engineered virus-like particles (eVLPs), creating a fifth-generation (v5) eVLP with enhanced production, transduction, and gene-editing efficiency. This system could pave the way for improved gene delivery vehicles in therapeutic applications.

17 Nov 2024

Are you falling for fake news? Age and analytical thinking might save you

Older adults and analytical thinkers excel at discerning true from false news, while ideological biases and political identity shape misinformation susceptibility in distinct ways.

17 Nov 2024

Zinc deficiency linked to increased risk of lung infection

Dietary zinc deficiency promotes lung infection by Acinetobacter baumannii bacteria -; a leading cause of ventilator-associated pneumonia, according to a new study published Nov. 15 in the journal Nature Microbiology.

15 Nov 2024

Antiseizure medications during pregnancy linked to neurodevelopmental risks in children

Children born to mothers who take antiseizure medications to manage seizures and psychiatric conditions during pregnancy may face increased risks of neurodevelopmental conditions, according to new data from researchers at Drexel's Dornsife School of Public Health.

15 Nov 2024

Researchers discover how mutations disrupt protein splicing and cause disease

An international research team has uncovered a new mechanism crucial to the production of cellular proteins.

15 Nov 2024

Specific redox protein identified as a critical regulator of ferroptosis

Researchers at Helmholtz Munich, in collaboration with colleagues at Tohoku University, have identified a specific redox protein as a critical regulator of ferroptosis - a form of regulated oxidative cell death.

15 Nov 2024

Blue light exposure may accelerate bone growth and early puberty in rats

Exposure to blue light, like that from smartphones or tablets, may accelerate bone growth and bone age, leading to early puberty in rats.

15 Nov 2024

Research sheds light on Salmonella’s ability to escape gut defenses

A new UC Davis Health study has uncovered how Salmonella bacteria, a major cause of food poisoning, can invade the gut even when protective bacteria are present.

15 Nov 2024

Study shows benefits of nature for children's mental health

A team of researchers from McGill and Université de Montréal's Observatoire pour l'éducation et la santé des enfants (OPES, or observatory on children's health and eduation), led by Sylvana Côté, found that spending two hours a week of class time in a natural environment can reduce emotional distress among 10- to 12-year-olds who had the most significant mental health problems before the program began.

15 Nov 2024

Vanderbilt receives $3.3 million grant to develop medications for preventing preterm birth

Vanderbilt University Medical Center is receiving $3.3 million over two years through the Advanced Research Projects Agency for Health's (ARPA-H) Sprint for Women's Health for its early-stage research efforts to develop medications designed to suppress premature uterine contractions during pregnancy.

15 Nov 2024

MEMPHIS system sheds light on vaccine response differences across ages

mRNA vaccines saved lives during the COVID-19 pandemic, but older people had less of an immune response to the vaccines than did younger adults. Why? Boston Children's researchers, led by Byron Brook, PhD, and Ofer Levy, MD, PhD, have found some answers, while providing proof-of-concept of a new system that can model vaccine responses in a dish.

15 Nov 2024

Excessive sedentary time linked to higher heart disease risk

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a study in JACC, the flagship journal of the American College of Cardiology, and presented at the American Heart Association's Scientific Sessions 2024.

15 Nov 2024

Gut microbiome found to play key role in chronic disease progression

The gut microbiome, an ecosystem of trillions of microorganisms in the human digestive tract, has been increasingly linked to chronic diseases.

15 Nov 2024

Comprehensive database reveals protein changes associated with aging

With the worldwide population aging at an unprecedented rate, the prevention of age-related diseases has become a prominent issue.

15 Nov 2024

Increased physical activity could add 5 years to American lifespan

If every American over the age of 40 was as physically active as the top 25% of the population, they could expect to live an extra 5 years, on average, suggest the findings of a modelling study published online in the British Journal of Sports Medicine.

15 Nov 2024