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Baby teeth show when metal exposure may affect brain development

The study identifies critical windows of metal exposure via baby teeth, revealing impacts on brain development and behavior in children and adolescents.

30 Apr 2026

From killers to strategists: CAR T cells enter their multifunctional era

A review of 1,801 registered CAR T clinical trials shows that multifunctional designs now account for 533 trials and 33% of new CAR T products submitted for clinical testing in 2025. The field is shifting toward multitargeted, safety-controlled, cytokine-secreting, and checkpoint-modulating CAR T cells, but manufacturing, regulation, and limited clinical outcome data remain key barriers.

30 Apr 2026

Single-cell sequencing reveals why some CAR-T therapies succeed while others fail

Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.

30 Apr 2026

Metabolic rewiring could help CAR-T cells fight solid tumors

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.

29 Apr 2026

How multi-omics is changing what scientists can see in the human immune system

Human systems immunology is using multi-omics, single-cell tools, spatial technologies, and AI to decode immune responses across real-world human cohorts. The review highlights major opportunities for biomarker discovery and precision medicine, while stressing the need for rigorous study design, validation, and careful interpretation.

29 Apr 2026

Researchers use light-activated nanozymes to treat aggressive brain tumors

Brain tumors cannot always be successfully treated with conventional therapies. A team from Empa and the hospital network HOCH Health Ostschweiz is therefore developing nanozymes that can attack cancer cells directly in the brain during tumor surgery.

29 Apr 2026

Cells filter physical forces based on duration to detect disease

Scientists have discovered how cells decide when to respond to physical forces, potentially opening new avenues for tackling diseases such as cancer and fibrosis.

29 Apr 2026

New hybrid molecule uses Trojan horse approach to treat obesity

A team led by metabolism researcher Prof Timo D. Müller at Helmholtz Munich has developed a new approach for treating obesity and type 2 diabetes: a hybrid molecule uses the well-known GLP-1/GIP signalling pathway as a "door opener" and delivers an additional metabolic modulator specifically into the target cells.

29 Apr 2026

Maternal antibodies provide lifelong protection against adult gum disease

Mothers provide a hidden immune legacy that protects their children's teeth long after weaning is over. A new study reveals how maternal antibodies act as early life architects, programming the mouth to resist aggressive bacteria and prevent the bone loss associated with adult gum disease.

29 Apr 2026

Oxidative stress in aging brain inhibits essential enzymes

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena found that oxidative stress in the aging brain inhibits the activity of deubiquitylases.

29 Apr 2026

AGA update emphasizes lifestyle changes for effective hemorrhoid management

The American Gastroenterological Association (AGA) has released a new clinical practice update providing expert guidance on the diagnosis and treatment of hemorrhoids, a common condition affecting approximately 50% of people by age 50.

29 Apr 2026

New bioelectronic interface enables long-term vagus nerve stimulation for inflammation

Electrical stimulation of vagus nerve via implantable stimulators can effectively suppress inflammatory responses, offering a novel strategy for treating autoimmune diseases.

29 Apr 2026

Eating creates temporary metabolic state that boosts T cell function

Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects to the immune system shortly after a meal.

29 Apr 2026

Nerve fibers within melanomas found to slow tumor growth

Nerve fibers within melanomas can slow the growth of these tumors, according to a study led by Weill Cornell Medicine investigators.

29 Apr 2026

New vaccine strategy neutralizes diverse HIV variants

Researchers at Karolinska Institutet, in collaboration with colleagues at The Scripps Research Institute and Emory University, have developed a new vaccine strategy that has generated antibodies capable of neutralising highly divergent HIV variants.

29 Apr 2026

Technique will turbocharge new medicines to combat antimicrobial resistance

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29 Apr 2026

Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

Study reframes ADHD as disorder of energy regulation

The number of people in Europe diagnosed with attention deficit hyperactivity disorder (ADHD) has continued to rise steadily, not only among children, but increasingly among adults and women.

28 Apr 2026

Wearable sweat sensor tracks vitamin levels in real time

Researchers developed a wearable electrochemical patch that detects six vitamins in sweat at nanomolar levels, combining sweat induction, microfluidic sampling, wireless readout, and pH/ionic-strength calibration. Human testing focused mainly on vitamin B9, showing sweat levels rose after supplementation or a vitamin B9-rich diet and correlated with serum levels, supporting future use for non-invasive nutrition trend monitoring.

28 Apr 2026

Epigenetic changes reshape Dicer enzyme function in cancer and reproduction

Activation of a specific part of the Dicer enzyme can change its shape in a way that affects its critical role in proper cell division, with implications for both cancer biology and fertility, according to researchers at The University of Texas MD Anderson Cancer Center.

28 Apr 2026