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Psoriasis caused by changes in the fat metabolism of skin cells

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis - and at the same time represents a potential biomarker for a new treatment concept.

11 Dec 2025

What happens to your body during an ultramarathon? New study reveals key metabolic changes

This study tracked ultramarathon runners across 100 km, 160.9 km, and 230 km events to examine real-world metabolic, hormonal, and muscle stress responses. Severe energy deficits, muscle damage, and heterogeneous hormonal shifts were observed, with the greatest strain seen in the 230 km distance.

10 Dec 2025

Driving simulator exposes early Parkinson’s impairments that routine tests fail to detect

A high-fidelity driving simulator detected subtle visuospatial, attentional, and reaction time impairments in people with mild to moderate Parkinson’s disease, even when standard cognitive tests appeared normal. The study shows that simulator-based assessments can uncover real-world driving difficulties linked to disease severity that traditional screening tools often miss.

10 Dec 2025

New AAN guideline offers treatment strategies for functional seizures

To help neurologists, mental health clinicians and other clinicians determine the best ways to help people manage functional seizures, the American Academy of Neurology has issued a new guideline, published on December 10, 2025, in Neurology, the medical journal of the American Academy of Neurology.

10 Dec 2025

Disrupted genome architecture drives lymphoma development

Cancer isn't just about broken genes-it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services.

10 Dec 2025

Expanded donor matching makes stem cell transplants accessible

For years, the search for a stem cell donor has felt like a quest for a rare key-one that fits a lock with eight intricate tumblers, each representing a genetic marker.

10 Dec 2025

Screen time and ADHD: why social media stands out from gaming and TV

Over four years in a large US cohort, greater social media use was associated with small but consistent increases in inattention symptoms in children, while video games and television were not. Genetic risk for ADHD did not modify this inattention association, and analyses supported a directional link from social media use to later attention difficulties.

10 Dec 2025

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Deep learning uncovers why synthetic cannabinoids cause harmful effects

New psychoactive substances, originally developed as potential analgesics but abandoned due to adverse side effects, may still have pharmaceutical value if researchers could nail down the causes of those side effects.

10 Dec 2025

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing terminal exhaustion and enhancing tumour control in mice. This metabolic reprogramming also boosts responsiveness to PD-1 blockade, suggesting a potential strategy to improve cancer immunotherapy.

10 Dec 2025

Why the form of vitamin B12 you take may matter more than your intake

This comprehensive review examines vitamin B12 absorption, physiological roles, deficiency states, and dietary sources, with particular attention to differences between natural and synthetic forms. The authors conclude that while all B12 forms raise circulating levels, methylcobalamin may offer advantages in specific clinical contexts, especially where absorption or metabolic conversion is impaired.

10 Dec 2025

Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

Synaptic plasticity — the brain's ability to modify the connections between neurons to support learning — is one of the neural functions profoundly altered in Huntington's disease, with a direct impact on brain function.

10 Dec 2025

Study elucidates novel mitochondrial mechanisms underlying anti-aging and longevity

As life expectancy continues to climb globally, the focus of many people has moved from longevity alone to living in good health.

10 Dec 2025

Targeting inflammation may reduce depression severity and anhedonia

Naoise Mac Giollabhui, PhD, of the Department of Psychiatry at Mass General Brigham, is the lead author of a paper published in American Journal of Psychiatry, "Effect of anti-inflammatory treatment on depressive symptom severity and anhedonia in depressed individuals with elevated inflammation: Systematic review and meta-analysis of randomized controlled trials." Richard Liu, PhD, of the Department of Psychiatry at Mass General Brigham, is the senior author.

10 Dec 2025

Anxiety and insomnia linked to reduced natural killer cell levels in young women

Natural killer (NK) cells are the bodyguards of our immune system. As a first line of defense, they destroy invading pathogens, foreign bodies, and infected cells in early stages, thereby preventing them from spreading.

10 Dec 2025

Filtered coffee shows a causal link to healthier HbA1c levels

Genetically predicted filtered coffee consumption is causally associated with lower HbA1c levels, while other coffee preparation methods show no such benefit. This effect appears to be partly mediated by increases in propionate producing gut bacteria, particularly Veillonella.

10 Dec 2025

Early warning for diabetes: AI model identifies prediabetes risk with high accuracy

A Scientific Reports study developed a pattern neural network that integrates total antioxidant status with clinical and metabolic markers to predict prediabetes in Indian adults. The model achieved very high accuracy and highlighted oxidative stress and waist circumference as key predictors, supporting earlier detection before progression to type 2 diabetes.

10 Dec 2025

Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

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Medical Science News

Psoriasis caused by changes in the fat metabolism of skin cells

What happens to your body during an ultramarathon? New study reveals key metabolic changes

Driving simulator exposes early Parkinson’s impairments that routine tests fail to detect

New AAN guideline offers treatment strategies for functional seizures

Disrupted genome architecture drives lymphoma development

Expanded donor matching makes stem cell transplants accessible

Screen time and ADHD: why social media stands out from gaming and TV

AI turns routine pathology slides into powerful maps of the tumor immune landscape

Deep learning uncovers why synthetic cannabinoids cause harmful effects

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Why the form of vitamin B12 you take may matter more than your intake

Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

Study elucidates novel mitochondrial mechanisms underlying anti-aging and longevity

Targeting inflammation may reduce depression severity and anhedonia

Anxiety and insomnia linked to reduced natural killer cell levels in young women

Filtered coffee shows a causal link to healthier HbA1c levels

Early warning for diabetes: AI model identifies prediabetes risk with high accuracy

Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

Study offers a unified biological model to explain the causes of autism

Surprising new function of immune cells uncovered: Excess weight loss prevention

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

Extending the reach of Amperia™

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