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New clinical guideline adopts holistic approach to brain and heart health

A new brain–heart clinical practice guideline takes a holistic approach, integrating neurologic and mental health evidence with guidance for cardiovascular disease as many brain and heart conditions overlap and share similar risk factors.

30 Mar 2026

Mount Sinai researchers identify a highly prevalent recessive neurodevelopmental disorder

Researchers at the Icahn School of Medicine at Mount Sinai in New York have identified and described a previously unknown recessive neurodevelopmental disorder (NDD) that appears to be the most prevalent ever discovered.

30 Mar 2026

CFHR1 could be a new diagnostic marker for IgA nephropathy

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial cell proliferation, enhanced extracellular matrix production, and variable infiltration of inflammatory cells.

30 Mar 2026

Probiotic therapy may offer a simple strategy to help prevent premature births

Preterm birth is a major cause of neonatal illness and death, especially among women with a history of premature delivery.

30 Mar 2026

NOX-1 identified as key molecular target to prolong ketamine's antidepressant effects

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers rapid relief, its antidepressant effects fade within a few weeks.

30 Mar 2026

Benefits from food fortification, yet global nutrient gaps persist

While food fortification reduces micronutrient inadequacies, additional interventions are necessary to ensure balanced nutrition and prevent excess intake.

30 Mar 2026

Taking a placebo knowingly still improves stress and memory

Research indicates open-label placebos can ease stress and boost memory in older adults, presenting a novel, ethical strategy for promoting healthy aging.

30 Mar 2026

Parasites trigger a gut-to-brain signal that cuts food intake during infection

Researchers found that intestinal tuft cells signal to crypt enterochromaffin cells by releasing acetylcholine, triggering serotonin release and activating a gut-to-brain vagal pathway during type 2 inflammation. This sustained signalling, rather than the initial acute response, was linked to reduced food intake in mouse models of parasitic infection.

29 Mar 2026

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

29 Mar 2026

APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026

Heart structure changes in midlife linked to long-term disease risk

Higher left atrial end-systolic dimension (LASD), an increased measurement of the left upper chamber of the heart, and left ventricular mass (LVM), a clinical measurement of the weight of the heart's left ventricular myocardium, are well-established indicators of cardiovascular damage that are associated with a higher risk of cardiovascular disease (CVD) in the short-term (less than 10 years).

28 Mar 2026

Terahertz radiation alters metabolism and signaling in melanoma cells

Terahertz (THz) radiation is increasingly explored for biomedical applications, however, its non-thermal effects on cellular metabolism and regulatory networks remain insufficiently characterized.

28 Mar 2026

Brain resilience peaks about an hour after stress exposure

Psychological resilience is often misunderstood as simple "toughness" or an insensitivity to stress. However, true resilience is the brain's capacity to adapt and recover after a stressful event.

28 Mar 2026

Perceived partner effort boosts cognitive control during cooperative tasks

A study assesses whether perceiving a partner's effort leads to greater engagement of executive control mechanisms to maintain focus on a task.

28 Mar 2026

New mother’s experience highlights importance of postpartum heart care

At 35, Brooklyn resident Luyba Caloras was healthy, with no history of heart problems and no reason to think she was at risk of them. But pregnancy can act as a stress test on the heart—and soon after delivering her son at NYU Langone Health on February 3, 2024, she was diagnosed with a complication she never expected.

27 Mar 2026

New method reveals hidden protein motions for improved drug design

For many of us "protein" is the key element of a food order. However, beyond your preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is encoded in our genes.

27 Mar 2026

Gut immune responses found to trigger brain inflammation in MS

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS).

27 Mar 2026

New neural organoid system improves scalability and reproducibility for research

Neural organoids have been heralded as having huge potential for advancing our knowledge of the brain in several fields.

27 Mar 2026

HOBIT device improves oxygen supply for drug-producing cells

Implanting living cells as long-term drug producers could transform treatment for numerous diseases, but it is difficult to house the tiny workers in quantities high enough to ensure dosage needs are met while also keeping the cells alive and thriving.

27 Mar 2026

Aging lung cells drive severe inflammation in flu and COVID

Older adults are much more likely to become seriously ill from flu or COVID because aging lung cells can drive excessive immune responses, according to a new study led by researchers at UC San Francisco.

27 Mar 2026