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Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

The discovery could serve as a starting point for antiviral strategies. A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human coronavirus HCoV-229E and mediates the phosphorylation of the viral nucleocapsid (N) protein, an integral step in the virus cycle.

7 Nov 2025

New delivery particle could make mRNA vaccines cheaper and more effective

A new delivery particle developed at MIT could make mRNA vaccines more effective and potentially lower the cost per vaccine dose.

7 Nov 2025

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

BIOVECTRA, a part of Agilent Technologies Inc., and Revolution Biomanufacturing Inc. today announced a collaboration that grants BIOVECTRA access to Revolution Biomanufacturing's proprietary platforms for optimizing untranslated regions (UTRs) and codon usage to enhance mRNA stability and translational efficiency.

6 Nov 2025

Intensive mind-body retreat rapidly alters brain function and blood biology

Researchers at the University of California San Diego have found that an intensive retreat combining multiple mind-body techniques, including meditation and healing practices, produced rapid and wide-ranging changes in brain function and blood biology.

6 Nov 2025

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

Researchers at Moffitt Cancer Center have developed a novel biomaterial-based system that induces the formation of tertiary lymphoid-like structures, or TLSs.

6 Nov 2025

SNAP benefits fail to fund healthy diets for many Americans, study shows

A new study reveals that while the Harvard Healthy Eating Pattern aligns with SNAP benefits, the Mediterranean and DASH diets often exceed allowable costs, particularly for individuals with higher calorie needs, highlighting a systemic “poverty tax” on healthy eating.

6 Nov 2025

Scientists turn human stomach cells into insulin-producing beta cells

Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide.

6 Nov 2025

Can creatine help with depression? New review says results are inconclusive

Creatine supplementation may modestly reduce depressive symptoms, but the effect is small, uncertain, and likely influenced by study bias. The evidence remains of very low quality, highlighting the need for larger, well-designed clinical trials.

6 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute.

6 Nov 2025

Scientists identify essential process that protects DNA integrity in reproductive cells

A team of scientists at the University of Seville has identified an essential process that protects DNA integrity in reproductive cells, providing new clues about how organisms avoid genetic defects during egg formation.

6 Nov 2025

Evolving epidemiology of invasive Group A Streptococcus in critical care

Streptococcus pyogenes or invasive Group A Streptococcus (iGAS) is a major clinical concern around the world, since iGAS infections can quickly escalate into life-threatening conditions such as necrotizing fasciitis, septic shock, and pneumonia.

6 Nov 2025

Two main methods for discovering disease genes reveal distinct aspects of biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes, with major implications for drug development.

6 Nov 2025

Study identifies molecular brake that controls overactive killer T cells

"Why do immune cells that are supposed to eliminate viruses suddenly turn against our own body?"

6 Nov 2025

New combination treatment overcomes resistance in ER positive breast cancer

In preclinical studies, researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have tested a new combination therapy for hormone-resistant, estrogen receptor-positive (ER+) breast cancer and were able to shrink tumors, reduce the number of cancer stem cells and reprogram the immune environment to be less supportive of cancer growth.

6 Nov 2025

Longevity gene offers clues to extending life without restrictive diets

The pursuit of a longer life may currently be trending for tech bros, but the notion of a fountain of youth, or even immortality, has intrigued people for millennia.

6 Nov 2025

Body fat cutoff points identified for optimal soccer performance

A recent study has established clear, practical cutoff points for body fat measurements that are strongly associated with physical performance of male professional soccer players.

5 Nov 2025

How a few bat clades, not all, shape global spillover risk

Researchers have revealed that viral epidemic potential is not evenly distributed across bat lineages, with transmissibility, virulence, and death burden clustered in specific clades. The findings challenge the perception that all bats are equally high-risk, supporting targeted surveillance and conservation approaches.

5 Nov 2025

World’s largest eye imaging and data resource expands across the UK

The world's largest collection of curated eye imaging and linked clinical data is expanding across the country, in an initiative led out of Moorfields Eye Hospital NHS Foundation Trust and UCL (University College London).

5 Nov 2025

Oxidative stress linked to repetitive behaviors in mice

Abnormal repetitive behaviors in mice are strongly linked to multiple biomarkers of oxidative stress, which occurs when antioxidants cannot counteract the effects of harmful molecules in the body, according to a study published November 5, 2025, in the open-access journal PLOS One by Kendall Coden and Dr. Joseph Garner of Stanford University, U.S.

5 Nov 2025

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Medical Science News

Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

New delivery particle could make mRNA vaccines cheaper and more effective

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

Intensive mind-body retreat rapidly alters brain function and blood biology

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

SNAP benefits fail to fund healthy diets for many Americans, study shows

Scientists turn human stomach cells into insulin-producing beta cells

Can creatine help with depression? New review says results are inconclusive

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Scientists identify essential process that protects DNA integrity in reproductive cells

Evolving epidemiology of invasive Group A Streptococcus in critical care

Two main methods for discovering disease genes reveal distinct aspects of biology

Study identifies molecular brake that controls overactive killer T cells

New combination treatment overcomes resistance in ER positive breast cancer

Longevity gene offers clues to extending life without restrictive diets

Body fat cutoff points identified for optimal soccer performance

How a few bat clades, not all, shape global spillover risk

World’s largest eye imaging and data resource expands across the UK

Oxidative stress linked to repetitive behaviors in mice

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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