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Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

WSU researchers discover how a neural circuit drives relapse after opioid use

Washington State University researchers have discovered how a neural circuit – or a connection between two brain regions – drives relapse after opioid use, a finding that could lead to more effective treatments for opioid use disorders.

9 Dec 2025

Brain function discovery helps explain why childhood adversity raises metabolic disease risk in women

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life.

9 Dec 2025

Study uncovers how the body's bile acids bind to block C. diff's most dangerous toxin

In a major step towards a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to block C. diff's most dangerous toxin.

9 Dec 2025

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators.

9 Dec 2025

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

In a new preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors.

9 Dec 2025

Patients receiving T-cell redirecting therapies can safely be monitored at home

Patients who receive T-cell redirecting therapies are typically hospitalized for several days after treatment to watch for side effects.

9 Dec 2025

Accuracy of remote photoplethysmography drops sharply at elevated heart rates

Researchers at Bielefeld University have analyzed how reliably AI methods can detect pulse rates from simple video recordings.

9 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Study reveals how brain protein KCC2 influences reward learning

A new finding from researchers at Georgetown University Medical Center shows that the learning process of associating cues with rewards can be altered by increased or decreased activity of a specific protein in the brain.

9 Dec 2025

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.

8 Dec 2025

Hotter days and nights are already stealing sleep across the U.S.

Rising nighttime and daytime temperatures are associated with reduced sleep duration, poorer sleep continuity, delayed sleep onset, and altered sleep stages in a large U.S. cohort tracked with wearable devices. Vulnerability is greatest among adults aged 40–50 years, females, people with lower socioeconomic status, chronic conditions, and those living in marine climate zones, with climate change projected to further magnify sleep loss.

8 Dec 2025

Everyday PFAS exposure alters placental function in early pregnancy

This study measured real-life PFAS concentrations in first-trimester human placentas and used these data to create a pregnancy-relevant PFAS mixture. In 3D trophoblast spheroid models, the mixture altered invasion, hormone secretion, and gene expression without broadly reducing viability at environmentally relevant doses.

8 Dec 2025

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Early-life RSV infection and parental allergy interact to substantially increase childhood asthma risk, supported by population data from more than 1.5 million children and mechanistic mouse experiments. The study shows that viral infection reprograms neonatal immune responses by altering how maternally transferred allergen-specific antibodies are handled, driving long-term allergic airway disease.

8 Dec 2025

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

8 Dec 2025

Powerful prognostic marker could enable early identification of high-risk cancer patients

Aggressive T-cell lymphoma is a rare and devastating form of blood cancer with a very low five-year survival rate.

8 Dec 2025

Industrial and farm chemicals quietly alter the balance of gut microbes

This study systematically screened over 1,000 agricultural and industrial chemicals and found that many can inhibit human gut bacteria in vitro. Beyond antimicrobial effects, these chemicals act as selective pressures that can reshape microbial competition, tolerance mechanisms, and metabolic pathways.

8 Dec 2025

Lymphocyte levels help predict outcomes after CAR T-cell therapy in non-Hodgkin lymphoma

Measuring the lymphocytes - white blood cells that fight infection - in a patient's blood can be used to predict outcomes in non-Hodgkin lymphoma patients who receive CAR T-cell therapy, according to research from physicians at Fox Chase Cancer Center and Temple Health.

8 Dec 2025

Why female athletes need injury prevention rules built for women, not men

This International Olympic Committee consensus synthesised evidence from over 600 studies to develop 56 injury prevention recommendations tailored to female, woman and girl athletes. It concludes that reducing injury risk requires a whole sports system approach that integrates training, policy, environment and culture, not exercise alone.

8 Dec 2025

Poor dietary iron weakens lung memory T cells after flu infection

Dietary iron deficiency in mice alters lung T cell activation during influenza infection and leads to memory T cells that are present in normal or increased numbers but have impaired antiviral cytokine responses. These functional deficits are most pronounced in lung CD8-positive memory T cells and persist even under optimal recall conditions.

8 Dec 2025

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Medical Science News

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

WSU researchers discover how a neural circuit drives relapse after opioid use

Brain function discovery helps explain why childhood adversity raises metabolic disease risk in women

Study uncovers how the body's bile acids bind to block C. diff's most dangerous toxin

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

Patients receiving T-cell redirecting therapies can safely be monitored at home

Accuracy of remote photoplethysmography drops sharply at elevated heart rates

Online reference library provides a more accurate picture of drug exposure

Study reveals how brain protein KCC2 influences reward learning

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Hotter days and nights are already stealing sleep across the U.S.

Everyday PFAS exposure alters placental function in early pregnancy

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

Powerful prognostic marker could enable early identification of high-risk cancer patients

Industrial and farm chemicals quietly alter the balance of gut microbes

Lymphocyte levels help predict outcomes after CAR T-cell therapy in non-Hodgkin lymphoma

Why female athletes need injury prevention rules built for women, not men

Poor dietary iron weakens lung memory T cells after flu infection

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

Extending the reach of Amperia™

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