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Researchers develop powerful tools for microbiome research advancement

The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and the planet's ecosystems. Yet even with modern DNA sequencing, figuring out what these microbes are and how they are related to one another remains extremely difficult.

13 Dec 2025

Hypertrophic chondrocytes play a crucial role in bone growth and repair

Normal, regulated growth of skeletal bones is a crucial part of the growth of mammals. This is a complex process involving the growth of cartilaginous cells or chondrocytes, their transformation into bone-building cells or osteoblasts, and the formation of new blood vessels to supply the newly formed bone tissue.

13 Dec 2025

Cryo-EM reveals NPFFR1 activation and guides novel ligand design

This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1 (NPFFR1)-a Gi/o-coupled receptor that responds to endogenous RF-amide peptides (RFRP-3 from pro-NPFFB, NPFF from pro-NPFFA) and regulates physiological processes like opioid function, pain, and energy homeostasis.

13 Dec 2025

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

Fibrosis, resulting from excess extracellular matrix (ECM) deposition, is a feature of adipose tissue (AT) dysfunction and obesity-related insulin resistance.

13 Dec 2025

External signals control oncolytic bacteria for precise cancer therapy delivery

Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic delivery. This review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy.

13 Dec 2025

New research reveals the impact of DNA-histone cross-links on genome stability

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within nucleosomes, yet their structural and functional consequences remain poorly understood due to their instability and low natural abundance.

13 Dec 2025

Bioluminescent tool illuminates single-cell activity in living brains

A decade ago, a group of scientists had the literally brilliant idea to use bioluminescent light to visualize brain activity.

12 Dec 2025

Virus shells use asymmetry to control RNA release and infection

Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State reveals a deliberate imbalance in their shape that helps them infect their hosts.

12 Dec 2025

SN101 iPSC-derived therapy relieves chronic pain and preserves joints

SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach to chronic pain management and joint tissue preservation.

12 Dec 2025

Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract.

12 Dec 2025

Young tanning bed users show accelerated genetic aging in the skin

Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age.

12 Dec 2025

Indiana University physician joins FDA panel on male hormone therapy

Helen Bernie, DO, MPH, assistant professor of urology at Indiana University School of Medicine, will participate in an expert panel on testosterone replacement therapy and men's health to be held Wednesday, Dec. 10, by the U.S. Food and Drug Administration. Bernie's role on the panel is that of a clinical expert on men's reproductive health, which is the focus of both her practice and academic research.

12 Dec 2025

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors and clinical course, and underscoring the importance of early diagnosis and treatment.

12 Dec 2025

Exploring melatonin therapeutic potential in systemic lupus erythematosus

A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus (SLE), a complex autoimmune disease affecting multiple organs.

12 Dec 2025

Glycation stress drives aortic stiffening through oxidative stress and senescence

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence."

12 Dec 2025

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Heart attacks that occur at night are less severe than those that strike during the day. A new study from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) explains why. Published in the Journal of Experimental Medicine, the study led by Dr. Andrés Hidalgo's group at the CNIC shows that neutrophils-a type of white blood cell-have an internal clock that regulates their aggressiveness throughout the day and determines the extent of damage they cause to the heart after a heart attack.

12 Dec 2025

Tianjin grading system improves prognosis prediction in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is notoriously difficult to treat due to its aggressive nature and limited prognostic tools.

12 Dec 2025

Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity

A scientific review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves.

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.

12 Dec 2025

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Medical Science News

Researchers develop powerful tools for microbiome research advancement

Hypertrophic chondrocytes play a crucial role in bone growth and repair

Cryo-EM reveals NPFFR1 activation and guides novel ligand design

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

External signals control oncolytic bacteria for precise cancer therapy delivery

New research reveals the impact of DNA-histone cross-links on genome stability

Bioluminescent tool illuminates single-cell activity in living brains

Virus shells use asymmetry to control RNA release and infection

SN101 iPSC-derived therapy relieves chronic pain and preserves joints

Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

Young tanning bed users show accelerated genetic aging in the skin

Indiana University physician joins FDA panel on male hormone therapy

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Exploring melatonin therapeutic potential in systemic lupus erythematosus

Glycation stress drives aortic stiffening through oxidative stress and senescence

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Tianjin grading system improves prognosis prediction in pancreatic cancer

Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

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